Respiratory Viruses Learning Outcomes
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Questions and Answers

Which of the following is NOT a symptom of upper respiratory viral infection?

  • Rhinitis
  • Bronchiolitis (correct)
  • Sore throat
  • Cough
  • What is the main concern associated with lower respiratory viral infection?

  • Sore throat
  • Pharyngitis
  • Respiratory failure (correct)
  • Runny nose
  • When is the seasonality of respiratory viruses typically observed?

  • October - December (correct)
  • July - September
  • April - June
  • January - March
  • What is a key aspect of understanding respiratory viral infections?

    <p>Understanding the burden of respiratory viruses</p> Signup and view all the answers

    Which type of virus is responsible for 10-15% of common colds?

    <p>Coronavirus</p> Signup and view all the answers

    Which virus is known to cause respiratory infections that lead to multiple organ dysfunction?

    <p>SARS-CoV-2</p> Signup and view all the answers

    Which virus is the largest RNA virus known?

    <p>Coronavirus</p> Signup and view all the answers

    Which virus has the potential for pandemic spread, especially after spillover from bat-borne viruses?

    <p>SARS-CoV-2</p> Signup and view all the answers

    Which type of virus has the largest host range?

    <p>Influenza A</p> Signup and view all the answers

    Which virus is responsible for most human influenza infections?

    <p>Influenza A</p> Signup and view all the answers

    Which virus type is responsible for causing acute kidney injury?

    <p>SARS-CoV-2</p> Signup and view all the answers

    Which virus binds to sialic acid receptors through its HA proteins?

    <p>Influenza A</p> Signup and view all the answers

    'Reassortment' occurs most commonly in which type of influenza virus?

    <p>Influenza A</p> Signup and view all the answers

    'Antigenic drift' occurs most frequently in which type of influenza virus?

    <p>Influenza A</p> Signup and view all the answers

    'Internalisation' of the virus occurs through endocytosis in which type of influenza virus?

    <p>Influenza B</p> Signup and view all the answers

    Which virus is responsible for pleomorphic symptoms?

    <p>Influenza B</p> Signup and view all the answers

    Which virus is responsible for over 50% of Upper Respiratory TI?

    <p>Rhinovirus</p> Signup and view all the answers

    What is the most common cause of respiratory infection in infants and young children?

    <p>Respiratory Syncytial Virus (RSV)</p> Signup and view all the answers

    What is the primary cause of the 'common cold'?

    <p>Rhinovirus</p> Signup and view all the answers

    Which virus prefers a temperature of 32°C?

    <p>Rhinovirus</p> Signup and view all the answers

    Which virus has been responsible for more hospitalizations in vaccinated children and caused deaths?

    <p>Respiratory Syncytial Virus (RSV)</p> Signup and view all the answers

    Which virus is transmitted through aerosols/microdroplets and fomites?

    <p>Rhinovirus</p> Signup and view all the answers

    Which virus has the potential for zoonotic spillover?

    <p>Coronavirus</p> Signup and view all the answers

    Which virus has maternal immunization as an antibody treatment known as palivizumab or Synagis?

    <p>Respiratory Syncytial Virus (RSV)</p> Signup and view all the answers

    'Respiratory failure' is more likely to be caused by which virus?

    <p>(RSV) Respiratory Syncytial Virus</p> Signup and view all the answers

    Which virus has three groups/species (A, B, and C) with approximately 160 serotypes identified?

    <p>(RV) Rhinovirus</p> Signup and view all the answers

    Which virus does not currently have a vaccine available?

    <p>(RV) Rhinovirus</p> Signup and view all the answers

    Which virus causes syncytia, mostly observed in cell culture, and is linked to the development of asthma right upper lobe atelectasis?

    <p>(RSV) Respiratory Syncytial Virus</p> Signup and view all the answers

    Respiratory viruses are not a significant burden on public health.

    <p>False</p> Signup and view all the answers

    Influenza virus is not associated with lower respiratory failure.

    <p>False</p> Signup and view all the answers

    Respiratory viruses are not known to exhibit seasonality.

    <p>False</p> Signup and view all the answers

    Respiratory Syncytial Virus (RSV) does not cause bronchiolitis in children.

    <p>False</p> Signup and view all the answers

    Respiratory viral infections are not associated with multiple organ dysfunction.

    <p>False</p> Signup and view all the answers

    Influenza virus does not have the potential for pandemic spread.

    <p>False</p> Signup and view all the answers

    RSV is responsible for the majority of upper respiratory tract infections in infants and young children.

    <p>True</p> Signup and view all the answers

    Rhinovirus primarily uses CDHR3 receptor for cellular entry.

    <p>False</p> Signup and view all the answers

    Respiratory Syncytial Virus (RSV) has a vaccine available for treatment.

    <p>False</p> Signup and view all the answers

    Rhinoviruses prefer a temperature of 37°C for optimal replication.

    <p>False</p> Signup and view all the answers

    RSV replication can be limited by oxidative stress.

    <p>True</p> Signup and view all the answers

    Coronaviruses have only been found to infect birds among the listed animals.

    <p>False</p> Signup and view all the answers

    Rhinovirus is responsible for over 50% of upper respiratory tract infections.

    <p>True</p> Signup and view all the answers

    Respiratory Syncytial Virus (RSV) primarily uses sialic acid receptors for cellular entry.

    <p>False</p> Signup and view all the answers

    Rhinoviruses exhibit similar cytokine production regardless of their serotypes.

    <p>True</p> Signup and view all the answers

    A vaccine trial with Rhinovirus failed to generate stable antibodies against the pre-fusion glycoprotein.

    <p>False</p> Signup and view all the answers

    Respiratory Syncytial Virus (RSV) causes atelectasis and respiratory failure in infected individuals.

    <p>True</p> Signup and view all the answers

    Rhinovirus is transmitted through aerosols/microdroplets and fomites.

    <p>True</p> Signup and view all the answers

    Coronaviruses are responsible for over 50% of common colds.

    <p>False</p> Signup and view all the answers

    Influenza A and B are responsible for most human influenza infections.

    <p>True</p> Signup and view all the answers

    Coronavirus has been responsible for more hospitalizations in vaccinated children and caused deaths.

    <p>False</p> Signup and view all the answers

    SARS-CoV-2 has the potential for zoonotic spillover.

    <p>True</p> Signup and view all the answers

    Influenza has maternal immunization as an antibody treatment known as palivizumab or Synagis.

    <p>False</p> Signup and view all the answers

    Coronaviruses prefer a temperature of 32°C.

    <p>False</p> Signup and view all the answers

    Influenza A has the largest host range.

    <p>True</p> Signup and view all the answers

    'Respiratory failure' is more likely to be caused by Coronavirus.

    <p>False</p> Signup and view all the answers

    Influenza symptoms do not include upper respiratory viral infection.

    <p>False</p> Signup and view all the answers

    Coronavirus is the largest RNA virus known.

    <p>True</p> Signup and view all the answers

    'Reassortment' occurs most commonly in Influenza A virus.

    <p>True</p> Signup and view all the answers

    'Respiratory failure' is more likely to be caused by Influenza.

    <p>False</p> Signup and view all the answers

    Study Notes

    • Respiratory viruses cause various respiratory infections, including upper respiratory tract infections (runny nose, cough, sore throat, rhinitis, pharyngitis, laryngitis) and lower respiratory tract infections (bronchiolitis, pneumonia, respiratory failure).
    • Important respiratory viruses include Influenza virus and Respiratory Syncytial Virus (RSV).
    • Influenza virus:*
    • Classified as a negative-sense ssRNA virus.
    • Causes severe respiratory illness, especially in young children, the elderly, and immunocompromised individuals.
    • Annually causes 3-5 million severe cases and up to 650,000 deaths worldwide.
    • Virions are pleomorphic and contain 10 genes encoding 11 proteins.
    • Spread through respiratory droplets and close contact.
    • RSV:*
    • First discovered in 1956 and is the leading cause of respiratory infections in infants and young children.
    • Virtually all children are infected by age 2 and are reinfected throughout life.
    • Causes upper and lower respiratory infections, including bronchiolitis, pneumonia, and respiratory failure.
    • Divided into two subtypes A and B based on the F and G proteins.
    • Transmitted through respiratory droplets and close contact.
    • Common features of respiratory viruses:*
    • Both RSV and influenza viruses can cause syncytia and inflammation, which can lead to more serious conditions, such as respiratory failure.
    • Both viruses have mechanisms to evade the immune response and delay apoptosis, allowing them to persist in the host.
    • RSV pathogenesis:*
    • Incubation period of 2-8 days.
    • Can lead to serious complications, such as atelectasis and respiratory failure.
    • Infection results in inflammation, inflammatory cell infiltration, and increased mucous production.
    • Can trigger the development of asthma.
    • RSV diagnosis and treatment:*
    • Diagnosis is typically done through PCR or rapid antigen tests.
    • No vaccine or treatment is currently available.
    • Palivizumab, a humanized monoclonal antibody, is available for high-risk children.
    • Rhinovirus:*
    • Commonly causes the 'common cold' and is responsible for over 50% of upper respiratory tract infections.
    • Three groups/species of rhinovirus: A, B, and C.
    • Uses ICAM1 and CDHR3 receptors for attachment.
    • Transmitted through aerosols/microdroplets and fomites.
    • Rhinovirus pathogenesis:*
    • Can cause exacerbations of asthma.
    • Disrupts the junctions between cells, leading to increased airway responsiveness.
    • Results in the production of pro-inflammatory cytokines.

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    Respiratory Viruses PDF

    Description

    Learn about the burden, history, epidemiology, virology, pathogenesis, and similarities and differences between important respiratory viruses in this educational quiz by Dr. Marine Petit. Understand the symptoms and characteristics of upper respiratory viral infections.

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