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Respiratory System Anatomy: Nasopharynx, Oropharynx, Laryngopharynx, Larynx
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Respiratory System Anatomy: Nasopharynx, Oropharynx, Laryngopharynx, Larynx

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Questions and Answers

What is the function of the mucosa membrane in the stomach and intestines?

  • Protection against corrosive acids
  • Has epithelial folds for expansion and increasing surface area (correct)
  • Release of water, acids, enzymes, buffers
  • Serves as a barrier against bacteria
  • Which layer of the digestive tract is responsible for protecting tissues from corrosive acids and enzymes?

  • Submucosa
  • Mucosa (correct)
  • Muscularis
  • Serosa/adventitia
  • What is the main function of Excretion in the digestive system?

  • Physical manipulation of solid foods
  • Removal of wastes from body fluids (correct)
  • Ingestion of food
  • Chemical breakdown of food
  • What happens during Absorption in the digestive process?

    <p>Movement of small molecules across digestive epithelium</p> Signup and view all the answers

    Which part of the digestive system is involved in Mechanical processing?

    <p>Tongue and teeth in oral cavity</p> Signup and view all the answers

    What is the primary role of Secretion in the digestive system?

    <p>Release of water, acids, enzymes, buffers by digestive tract</p> Signup and view all the answers

    Which layer of the digestive tract provides a nonspecific defense against bacteria?

    <p>Mucosa</p> Signup and view all the answers

    What is the final step in the digestive process involving waste removal?

    <p>(defecation) Waste is discharged as feces</p> Signup and view all the answers

    What is the function of the afferent arteriole in the kidney?

    <p>Facilitates greater blood flow in the capillaries</p> Signup and view all the answers

    Why does pressure increase in the kidneys due to the efferent arteriole?

    <p>Limits blood flow out of the capillaries</p> Signup and view all the answers

    What is Glomerular Filtration Rate (GFR) a measure of?

    <p>Amount of filtrate formed by both kidneys per minute</p> Signup and view all the answers

    How does Hydrostatic Pressure (HP) affect fluid movement?

    <p>Pushes fluid out of the container</p> Signup and view all the answers

    What is Colloid Osmotic Pressure (COP) created by in the kidney environment?

    <p>Proteins or solutes</p> Signup and view all the answers

    When will water move out according to hydrostatic and colloid osmotic pressures?

    <p>When HP is greater than COP</p> Signup and view all the answers

    What is Glomerular Hydrostatic Pressure (GHP) related to?

    <p>Pressure within the glomerular capillaries</p> Signup and view all the answers

    What is Capsular Colloid Osmotic Pressure (CCOP) influenced by?

    <p>Solutes already in the filtrate</p> Signup and view all the answers

    What is the function of the greater omentum?

    <p>Drapes a 'fatty apron' over the transverse colon and small intestine</p> Signup and view all the answers

    What are compounds that do not dissociate called?

    <p>Non-electrolytes</p> Signup and view all the answers

    Where do lingual tonsils situate?

    <p>At base of tongue</p> Signup and view all the answers

    In the context of fluid balance, what does excess gain require?

    <p>Selective elimination</p> Signup and view all the answers

    What is the main function of the falciform ligament?

    <p>Attaches liver to anterior wall and diaphragm</p> Signup and view all the answers

    Which of the following best describes electrolyte balance?

    <p>Constant ion levels</p> Signup and view all the answers

    What role do salivary glands play in the oral cavity?

    <p>Secrete saliva into the oral cavity to lubricate, dissolve, and begin food breakdown</p> Signup and view all the answers

    What does the production of H+ ions being equal to their loss indicate in acid-base balance?

    <p>Equilibrium</p> Signup and view all the answers

    Which factor results in a greater hold of water in muscle compared to adipose tissue?

    <p>Muscle activity</p> Signup and view all the answers

    What distinguishes the cheeks in the oral cavity?

    <p>Together with lips, teeth, and gums form the oral vestibule</p> Signup and view all the answers

    How does the intracellular fluid volume compare to the plasma volume?

    <p>$25L$ : $12L$</p> Signup and view all the answers

    Which part separates the oral nasal cavity and forms the roof of the mouth?

    <p>Hard palate</p> Signup and view all the answers

    What is the function of mesenteries in the abdominal cavity?

    <p>Help stabilize the position of abdominal organs and prevent entanglement</p> Signup and view all the answers

    Which body fluid compartment provides a constant environment?

    <p>ECF</p> Signup and view all the answers

    'Orbicularis Oris' muscles are primarily found in which part of the oral cavity?

    <p>'Fleshy folds' containing orbicularis oris muscle</p> Signup and view all the answers

    What remains relatively constant in terms of fluid balance?

    <p>$H_2O$ levels</p> Signup and view all the answers

    What type of epithelium lines the nasopharynx for the exchange of small amounts of air with auditory tubes?

    <p>Pseudostratified ciliated</p> Signup and view all the answers

    Which of the following is NOT part of the larynx?

    <p>Hyoid bone</p> Signup and view all the answers

    What is the function of the epiglottis during swallowing?

    <p>It folds back over the glottis to prevent entry</p> Signup and view all the answers

    Which ligaments extend across the larynx between the thyroid and smaller cartilages?

    <p>False vocal cords</p> Signup and view all the answers

    What is the main function of the true vocal cords in the larynx?

    <p>Produce sound for speech</p> Signup and view all the answers

    Which muscle type connects cartilages and structures in the throat?

    <p>Extrinsic muscles</p> Signup and view all the answers

    What causes variation in pitch related to tension in the vocal cords?

    <p>Tension changes in the folds of the vocal cords</p> Signup and view all the answers

    Which condition is characterized by viscous mucus impairing cilia and blocking air passageways?

    <p>Cystic fibrosis</p> Signup and view all the answers

    Where is the only layer present in capillaries located?

    <p>Tunica intima</p> Signup and view all the answers

    What happens when there is incompetence in the valves of veins?

    <p>Blood tends to pool</p> Signup and view all the answers

    What is the function of peripheral veins' increased number of valves?

    <p>Facilitate blood flow back to the heart</p> Signup and view all the answers

    Which part of the heart's circulation carries 30-35% of the blood volume?

    <p>Systemic circulation</p> Signup and view all the answers

    In what direction does blood flow from the right ventricle to lung arterioles in pulmonary circulation?

    <p>To pulmonary veins</p> Signup and view all the answers

    Which layer of blood vessels contains smooth muscle in both arteries and veins?

    <p>Tunica media</p> Signup and view all the answers

    What differentiates venules from veins in terms of blood entry?

    <p>Blood in venules enters progressively larger channels</p> Signup and view all the answers

    What defines pulmonary circulation in the heart's blood flow?

    <p>'Venous blood moves from right atrium to right ventricle to lung arterioles and capillaries.'</p> Signup and view all the answers

    Which force encourages fluid to leave the glomerular capillaries and move into the capsular space?

    <p>Colloids' affinity for water</p> Signup and view all the answers

    What does the Equilibrium Filtration Pressure (EFP) represent in the context of fluid dynamics in the kidneys?

    <p>Net pressure favoring fluid filtration</p> Signup and view all the answers

    What is the main function of Myogenic Mechanism in regulating Glomerular Filtration Rate (GFR)?

    <p>Decreasing GFR with increasing blood pressure</p> Signup and view all the answers

    What is directly correlated with the body's systemic blood pressure?

    <p>Glomerular Hydrostatic Pressure (GHP)</p> Signup and view all the answers

    How does an increase in afferent arteriole diameter affect Glomerular Filtration Rate (GFR)?

    <p>Increases GFR</p> Signup and view all the answers

    What could be a consequence of decreased Glomerular Filtration Rate (GFR) due to lowered systemic blood pressure?

    <p>Renal failure</p> Signup and view all the answers

    Which combination of forces make up the Equilibrium Filtration Pressure (EFP) in the kidneys?

    <p>(GHP + CHP) - (GCOP + CCOP)</p> Signup and view all the answers

    What factor triggers smooth muscle contraction in afferent arterioles resulting in decreased blood flow and Glomerular Filtration Rate (GFR)?

    <p>'Stretching' due to increased blood pressure</p> Signup and view all the answers

    What is the function of macula densa cells in the kidney?

    <p>Detect solute levels in the distal convoluted tubule</p> Signup and view all the answers

    Which cells release erythropoietin to stimulate the production of red blood cells?

    <p>Juxtaglomerular cells</p> Signup and view all the answers

    What is the role of the juxtaglomerular cells in the kidney?

    <p>Detect solute levels in the renal corpuscle</p> Signup and view all the answers

    Which system is activated when macula densa cells signal low solutes or glomerular filtration rate?

    <p>Renin-angiotensin-aldosterone system</p> Signup and view all the answers

    What initiates a series of enzymatic reactions known as RAS?

    <p>Renin release due to low GFR</p> Signup and view all the answers

    Which cells in the kidney are responsible for determining the status of solute levels in the distal convoluted tubule?

    <p>Macula densa cells</p> Signup and view all the answers

    What hormones are secreted by macula densa and juxtaglomerular cells?

    <p>Erythropoietin and renin</p> Signup and view all the answers

    What term is used to describe compounds that do not dissociate into ions?

    <p>Non-electrolytes</p> Signup and view all the answers

    Which body fluid compartment facilitates intracellular chemical reactions?

    <p>Intracellular fluid (ICF)</p> Signup and view all the answers

    What is the main factor that influences the greater hold of water in muscle compared to adipose tissue?

    <p>Muscle structure</p> Signup and view all the answers

    In the context of fluid balance, what does excess loss require?

    <p>Selective elimination</p> Signup and view all the answers

    What is the primary function of the extracellular fluid (ECF) compartment?

    <p>Transporting substances</p> Signup and view all the answers

    What is the primary function of the phosphate buffer system?

    <p>Regulates phosphate ions in ECF</p> Signup and view all the answers

    In maintaining acid-base balance, what happens when there is a shortage of H+?

    <p>Kidneys reabsorb more bicarbonate ions</p> Signup and view all the answers

    How does the carbonic acid bicarbonate buffer system respond to excess H+?

    <p>Increases CO2 levels</p> Signup and view all the answers

    What is the role of respiratory compensation in acid-base balance?

    <p>Regulation of pH by changing CO2 levels</p> Signup and view all the answers

    If the blood pH exceeds normal limits, what would be the expected result on respiration?

    <p>Increase in CO2 levels and H+ concentration</p> Signup and view all the answers

    What occurs during prolonged hyperventilation in relation to blood pH?

    <p>Alkalosis due to increased respiration rate</p> Signup and view all the answers

    How do the kidneys respond to an increase in blood pH?

    <p>Secrete more H+ and absorb more bicarbonate ions</p> Signup and view all the answers

    What is the main function of carbolic acid Bicarbonate buffer system?

    <p>Bicarbonate ion synthesized and reabsorbed by kidneys</p> Signup and view all the answers

    What is the primary function of the Superior vena cava in the circulatory system?

    <p>Supplies blood to the head, neck, upper extremities, and thoracic cavity</p> Signup and view all the answers

    Where do the Veins of the upper limb receive blood from according to the text?

    <p>Deep and superficial systems</p> Signup and view all the answers

    In which part of the body are the Extensions of capillaries mentioned in the text?

    <p>Brain</p> Signup and view all the answers

    What is the main source of blood for Inferior vena cava according to the provided text?

    <p>Lower extremities and abdomen</p> Signup and view all the answers

    Which part of the body receives blood supply from branches of subclavian arteries and descending thoracic aorta?

    <p>Thorax</p> Signup and view all the answers

    Where do the Veins of the head and neck drain into according to the text?

    <p>Dural sinuses</p> Signup and view all the answers

    What is one significant feature of the Systemic Circulation mentioned in the text?

    <p>Vessels decrease in size as they unite</p> Signup and view all the answers

    What distinguishes the Veins of the thorax and abdomen based on their drainage outlets?

    <p>'Drain into brachiocephalic and external iliac veins'</p> Signup and view all the answers

    What is the specialized area in the heart composed of myocytes that can spontaneously depolarize called?

    <p>Conduction network</p> Signup and view all the answers

    Which structure initiates each heartbeat and sets the pace for the heart's contractions?

    <p>Sinoatrial node</p> Signup and view all the answers

    What term is used to describe the property of being able to spontaneously initiate depolarization in heart muscle cells?

    <p>Autorhythmicity</p> Signup and view all the answers

    Why does the heart not require the central nervous system (CNS) to maintain its rhythm?

    <p>Due to the presence of specialized pacemaker cells</p> Signup and view all the answers

    What happens when autorhythmic cells in the heart reach a specific threshold?

    <p>An action potential is initiated</p> Signup and view all the answers

    Which term best describes the rhythmic electrical activity produced by autorhythmic cells in the heart?

    <p>Autorhythmic depolarization</p> Signup and view all the answers

    Where are the specialized pacemaker cells located that initiate each heartbeat in the heart's conduction system?

    <p>Right atrial wall</p> Signup and view all the answers

    What characteristic allows autorhythmic cells in the heart to start an action potential without external stimulation?

    <p>'Spontaneous depolarization' ability</p> Signup and view all the answers

    What is the main function of the RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RASS) in the kidney?

    <p>To regulate resistance in afferent and efferent arterioles</p> Signup and view all the answers

    What triggers the release of renin in the kidneys?

    <p>Low solutes and low GFR detected by macula densa cells</p> Signup and view all the answers

    Where are the macula densa cells located within the kidney?

    <p>Near the renal corpuscle</p> Signup and view all the answers

    What is the primary function of juxtaglomerular cells in the kidney?

    <p>Detect stretching of the afferent arteriole</p> Signup and view all the answers

    Which hormone is responsible for stimulating the production of red blood cells?

    <p>Erythropoietin</p> Signup and view all the answers

    What enzymatic reactions are set off by renin in response to low solutes/GFR?

    <p>RAS (Renin-Angiotensin System)</p> Signup and view all the answers

    Where are juxtaglomerular cells predominantly found within the kidney?

    <p>Around the afferent arteriole</p> Signup and view all the answers

    What do macula densa cells act as in the kidney environment?

    <p>Chemoreceptors</p> Signup and view all the answers

    What might be the consequence of hypotension leading to hypo-perfusion of critical organs?

    <p>Development of shock</p> Signup and view all the answers

    What is the primary function of lymphatics leaving nodes to form principal lymphatic trunks?

    <p>Draining excess interstitial fluid</p> Signup and view all the answers

    What is the role of lacteals in lymphatic capillaries?

    <p>Greater permeability to absorb proteins and lipids</p> Signup and view all the answers

    What causes lymphedema, resulting in limb swelling?

    <p>Accumulation of interstitial fluid due to lymphatic drainage blockage</p> Signup and view all the answers

    How does lymph flow through the lymphatic capillaries and vessels?

    <p>Against gravity from central body towards periphery</p> Signup and view all the answers

    What is the main function of the skeletal muscle pump in the flow of lymph?

    <p>Forcing lymph toward the heart through vessel compression</p> Signup and view all the answers

    In what way does respiratory lymph flow contribute to the movement of lymph?

    <p>Helps with an upward movement of lymph during exhalation</p> Signup and view all the answers

    'Milking action' is a term associated with which process in the context of lymph flow?

    <p>Contraction of muscles to compress lymphatic vessels and force lymph toward heart</p> Signup and view all the answers

    What is the main function of the countercurrent exchanger in the kidney system?

    <p>Maintaining urine concentration</p> Signup and view all the answers

    In the recycling of urea, what is the role of the medullary collecting system?

    <p>Passive diffusion of urea out of filtrate</p> Signup and view all the answers

    What drives the process of osmosis in renal filtration and urine concentration?

    <p>Concentration gradient in the interstitial fluid</p> Signup and view all the answers

    What is a key function of renal clearance measurement?

    <p>Calculating glomerular filtration rate (GFR)</p> Signup and view all the answers

    How does the micturition reflex contribute to urine ejection?

    <p>Inducing relaxation of external sphincters</p> Signup and view all the answers

    What is a common cause of adult urinary incontinence related to muscle weakness?

    <p>Weakness of deep pelvic floor muscles</p> Signup and view all the answers

    How does the vasa recta contribute to maintaining a concentration gradient in the medulla?

    <p>Supporting delivery of oxygen and nutrients to the medulla</p> Signup and view all the answers

    What effect does ADH have on water reabsorption in the medullary collecting duct?

    <p>Increases water reabsorption in response to decreased blood osmolarity</p> Signup and view all the answers

    Which lymphatic organ secretes thymosin to stimulate cell division and T cell maturation?

    <p>Thymus</p> Signup and view all the answers

    Which immune cells account for 25% of circulating White Blood Cells (WBCs) in the body?

    <p>Lymphocytes</p> Signup and view all the answers

    In which organ do plasma cells primarily develop from B cells to produce antibodies?

    <p>Bone marrow</p> Signup and view all the answers

    Which lymphoid organ is the largest collection of lymphoid tissue in the body and functions in the removal of microbes from blood?

    <p>Spleen</p> Signup and view all the answers

    Which immune response involves T cells defending against abnormal and infected cells in the body?

    <p>Cell-mediated immunity</p> Signup and view all the answers

    What is the primary function of the lymphocytes found in the lymph nodes during an immune response?

    <p>Activate T cells</p> Signup and view all the answers

    What triggers a cell-mediated attack against recipient tissue in graft versus host disease?

    <p>Activated T cells from the recipient</p> Signup and view all the answers

    Which autoimmune disease is characterized by antibodies that mimic Thyroid Stimulating Hormone (TSH)?

    <p>Graves Disease</p> Signup and view all the answers

    In autoimmune diseases involving antibody reactions, which condition involves antibodies preventing the binding of Acetylcholine (Ach) to its receptors?

    <p>Myasthenia Gravis</p> Signup and view all the answers

    Which autoimmune disease involves T cells and macrophages attacking the myelin sheath of nerves?

    <p>Multiple sclerosis</p> Signup and view all the answers

    Which immune response fails to develop or is blocked in immunodeficiency diseases?

    <p>Cell-mediated immune response</p> Signup and view all the answers

    What do autoimmune disorders primarily target in the body?

    <p>Self cells and tissues</p> Signup and view all the answers

    In immunotherapy for cancer, what is the goal of using antibodies like Herceptin?

    <p>Neutralize growth factors responsible for cancer cell growth</p> Signup and view all the answers

    'Grafts' that lead to an immune response when transplanted between people (non-twins) are known as:

    <p>Allografts</p> Signup and view all the answers

    'Immunosuppression' in allograft recipients primarily targets which aspect of immunity?

    <p>Both cellular and humoral immunity</p> Signup and view all the answers

    What is the principal type of hypersensitivity reaction characterized by IgE antibodies combining with antigens?

    <p>Type I (anaphylactic) reactions</p> Signup and view all the answers

    Which immune response involves the activation of T cells and B cells to inactivate pathogens and abnormal cells?

    <p>Adaptive immunity</p> Signup and view all the answers

    What is a common mediator involved in triggering anaphylactic shock by causing vasodilation of peripheral blood vessels?

    <p>Histamines</p> Signup and view all the answers

    In autoimmune diseases, what is the purpose of producing IgG instead of IgE through desensitization?

    <p>To block IgE-mediated allergic reactions</p> Signup and view all the answers

    Which type of hypersensitivity reaction involves prolonged contraction of smooth muscles triggered by leukotrienes and prostaglandins?

    <p>Type I (anaphylactic) reactions</p> Signup and view all the answers

    What is the immediate trigger for degranulation in anaphylactic reactions characterized by an immediate response?

    <p>Antibodies combining with receptors on mast cells</p> Signup and view all the answers

    Study Notes

    Nasopharynx

    • Located from internal nares to soft palate
    • Pseudostratified ciliated epithelium
    • Exchanges small amounts of air with auditory tubes

    Oropharynx

    • Located from soft palate to hyoid bone
    • Stratified squamous epithelium
    • Contains palatine and lingual tonsils

    Laryngopharynx

    • Located from hyoid bone to esophagus
    • Stratified epithelium
    • Contains epiglottis, thyroid cartilage, and cricoid cartilage
    • 2 pairs of smaller cartilages: arytenoid, corniculate, and cuneiform

    Larynx

    • Consists of 9 pieces of cartilage
    • Epiglottis folds back to prevent food from entering trachea during swallowing
    • Thyroid cartilage forms the Adam's apple
    • Cricoid cartilage provides support and protects the glottis and trachea

    Vocal Cords

    • Upper ligaments: false vocal cords
    • Lower folds: true vocal cords (principal structures in voice production)
    • Tension in vocal cords affects pitch

    Trachea

    • Also known as the windpipe
    • Located anterior to esophagus and attached to cricoid cartilage
    • Branches into bronchi
    • Semi-circular cartilaginous rings protect the airway

    Bronchi

    • Primary bronchi divide into secondary lobar bronchi
    • Secondary bronchi branch into tertiary segmental bronchi
    • Bronchioles: narrow, cartilage-free, and dominated by smooth muscle
    • Diameter of passageway controlled by sympathetic and parasympathetic nervous systems

    Digestive System

    • Consists of a muscular tube (digestive tract) and accessory organs
    • Functions: ingestion, mechanical processing, digestion, secretion, absorption, and excretion

    Digestive Tract Layers

    • Mucosa: protects tissues from corrosive acids and enzymes
    • Submucosa: provides mechanical support
    • Muscularis: contracts and relaxes to mix and propel food
    • Serosa/Adventitia: outermost layer

    Urinary Physiology

    • Filtration: glomerular hydrostatic pressure (GHP) > capsular colloid osmotic pressure (CCOP)
    • Balance: input = output
    • Fluid balance: fluid gained = fluid lost
    • Electrolyte balance: no net gain or loss of ions

    Acid-Base Balance

    • Regulated by buffer systems: protein, phosphate, and bicarbonate
    • Respiratory compensation: exhalation of CO2 and H+ buffering
    • Renal compensation: H+ excretion and bicarbonate ion reabsorption

    Lymphatic System

    • Components: vessels, fluid, lymphocytes, lymphoid tissues and organs
    • Functions: production, maintenance, distribution of lymphocytes, return of fluid and solutes, and hormone and nutrient distribution

    Lymphatic Vessels

    • Capillaries: smallest vessels, absorb proteins and lipids
    • Trunks and ducts: lymphatics unite to form principle lymphatic trunks
    • Thoracic duct: main return of venous blood

    Skeletal Muscle Pump

    • Contractions compress lymphatic vessels, forcing lymph toward the heart### The Heart as a Pump
    • Initiates each heartbeat through the sinoatrial (SA) node, which is located in the right atrial wall and has specialized pacemaker cells with an intrinsic rhythm called autorhythmicity.
    • Autorhythmic cells spontaneously depolarize at a given rate, resulting in an action potential that starts when cells reach threshold.

    Regulation of Blood Pressure

    • BP drop: arterioles dilate, increasing blood flow and GFR (glomerular filtration rate).
    • Vasoconstriction: decreases blood flow into the glomerulus.
    • Vasodilation: increases blood flow into the glomerulus.

    Renal Regulation

    • Tubuloglomerular feedback: a localized response that regulates the size of afferent and efferent arterioles, depending on the functioning of macula densa cells and juxtaglomerular cells.
    • Macula densa cells: chemoreceptors that determine the status of the filtrate in the distal convoluted tubule.
    • Juxtaglomerular cells: mechanoreceptors that detect stretching of the afferent arteriole and release renin when solutes/GFR are too low.

    Renin-Angiotensin-Aldosterone System (RAS)

    • Renin release: triggers a series of enzymatic reactions to regulate blood pressure.
    • Erythropoietin: stimulates production of RBCs.

    Countercurrent Systems

    • Countercurrent multiplier system: fluid travels in opposite directions, with Na, K, and Ca actively transported from filtrate into interstitial fluid.
    • Recycling of urea: medullary collecting system reabsorbs urea, concentrating it in the interstitial fluid.
    • Countercurrent exchanger: maintains the concentration gradient in the medulla.

    Urine Composition and Regulation

    • Urine contains: water, Na, K, Cl, H, phosphate, sulfates, metabolic wastes, and small amounts of bicarbonate, Ca, and Mg.
    • Renal clearance: measures the rate at which the kidneys remove a substance from the blood.
    • Regulation of urine concentration: depends on the concentration gradient in the interstitial fluid.

    Micturition Reflex

    • Stretch receptors in the bladder wall stimulate the brain, leading to the contraction of the detrusor muscle and the relaxation of the internal and external sphincters.
    • Voluntary relaxation of the external urethral sphincter causes the relaxation of the internal urethral sphincter, resulting in urination.

    Urinary Incontinence

    • Lack of voluntary control, resulting in the involuntary loss of urine.
    • Types: stress, urge, overflow, and functional incontinence.

    Overview of the Urinary System

    • Filtration produces a filtrate resembling blood plasma.
    • Reabsorption and secretion occur in the proximal convoluted tubule and other segments of the nephron.
    • Final composition and concentration of urine are determined by the distal convoluted tubule and collecting ducts.

    Fluid, Electrolyte, and Acid-Base Homeostasis

    • Chemical bonds between molecules permit dissociation.
    • Type II (cytotoxic) reaction: activates complement via the classical pathway, leading to cytolysis.
    • Type III (immune complex) reaction: occurs when antigen is in excess, leading to inflammatory damage.
    • Type IV (delayed cell-mediated) reaction: involves T cells and macrophages, resulting in an inflammatory response.

    Immune System

    • Primary lymphatic organs: bone marrow and thymus.
    • Secondary lymphatic organs: spleen, lymph nodes, tonsils, etc.
    • Thymus: develops and matures T cells, which attack foreign or abnormal cells.
    • Lymphocytes: account for 25% of circulating WBCs, including T cells, B cells, and NK cells.

    Lymphatic Organs

    • Spleen: largest collection of lymphoid tissue, responsible for defense, hematopoiesis, RBC/platelet destruction, and blood reservoir.
    • Lymph nodes: filter lymph, removing microbes and other injurious particles.
    • Tonsils: masses of lymphoid tissue, protecting the pharynx from exterior threats.

    Immune Response

    • Purpose: to inactivate/destroy pathogens and/or abnormal cells.
    • Involves coordinated activities of T cells and B cells.
    • Cell-mediated immunity: defends against abnormal cells, infected cells.
    • Antibody-mediated immunity: defends against antigens on body fluids.

    Hypersensitivity

    • Anaphylactic (Type I) reaction: an immediate response, involving IgE antibodies.
    • Cytotoxic (Type II) reaction: triggered by the binding of antibodies to antigens on cell surfaces.
    • Immune complex (Type III) reaction: occurs when antigen is in excess, leading to inflammatory damage.
    • Cell-mediated (Type IV) reaction: involves T cells and macrophages, resulting in an inflammatory response.

    Preventing Anaphylactic Reactions

    • Skin tests: diagnose allergies by inoculating small amounts of antigen beneath the epidermis.
    • Desensitization: series of injections gradually increasing doses of antigen, aiming to produce IgG instead of IgE.

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