Respiratory Physiology Quiz
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Questions and Answers

What primarily causes inhalation to occur?

  • Active engagement of accessory muscles
  • Expansion of the pleurae
  • Contraction of the diaphragm (correct)
  • Increased pressure in the thorax
  • Which muscles contribute to exhalation during normal quiet breathing?

  • External intercostals
  • Elastic recoil of chest wall and lungs (correct)
  • Diaphragm
  • Accessory muscles
  • What percentage of air entering the lungs during normal quiet breathing is contributed by the external intercostals?

  • 50%
  • 10%
  • 25% (correct)
  • 75%
  • What is the primary function of the pleural fluid?

    <p>To reduce friction and produce surface tension (B)</p> Signup and view all the answers

    How does surface tension of alveolar fluid influence the lungs?

    <p>Prevents collapse of alveoli at exhalation (C)</p> Signup and view all the answers

    Which statement accurately describes the lobes of the lungs?

    <p>The right lung has three lobes, while the left lung has two due to the cardiac notch. (C)</p> Signup and view all the answers

    Which factor affects the rate of airflow during pulmonary ventilation?

    <p>Lung compliance (D)</p> Signup and view all the answers

    What characterizes Type II alveolar cells?

    <p>They secrete alveolar fluid and contain microvilli. (D)</p> Signup and view all the answers

    During forceful exhalation, which muscle contractions contribute actively to the process?

    <p>Accessory muscles and abdominal muscles (A)</p> Signup and view all the answers

    What is the anatomical significance of the cardiac notch?

    <p>It makes the left lung approximately 10% smaller than the right lung. (A)</p> Signup and view all the answers

    What results from increased airway resistance?

    <p>Decreased airflow (A)</p> Signup and view all the answers

    What is the correct sequence of branching starting from terminal bronchioles?

    <p>Terminal bronchioles → respiratory bronchioles → alveolar ducts (D)</p> Signup and view all the answers

    What happens to intrapulmonic pressure as lung volume increases during inhalation?

    <p>It decreases (D)</p> Signup and view all the answers

    What is the partial pressure of carbon dioxide (PCO2) in the inhaled air?

    <p>0.3 mmHg (C)</p> Signup and view all the answers

    Which gas is estimated to be 24 times more soluble than oxygen in blood?

    <p>Carbon dioxide (C)</p> Signup and view all the answers

    During external respiration, when does oxygen diffusion stop?

    <p>When the PO2 of pulmonary capillary blood equals that of alveolar air (B)</p> Signup and view all the answers

    What is the total pressure of gases in inhaled air?

    <p>760 mmHg (A)</p> Signup and view all the answers

    Why does nitrogen dissolve in blood to a lesser extent compared to carbon dioxide?

    <p>Nitrogen is less soluble in blood (A)</p> Signup and view all the answers

    What is the primary function of the conducting zone in the respiratory system?

    <p>Conducts air to the lungs (B)</p> Signup and view all the answers

    Which part of the respiratory system is directly responsible for gas exchange?

    <p>Alveoli (B)</p> Signup and view all the answers

    What structures are included in the upper respiratory system?

    <p>Nose and pharynx (A)</p> Signup and view all the answers

    What is the purpose of the nasal conchae within the nasal cavity?

    <p>To filter and warm the air (D)</p> Signup and view all the answers

    Which muscle action is primarily assisted by the pharynx during swallowing?

    <p>Contraction of skeletal muscles (B)</p> Signup and view all the answers

    What structure closes off the glottis during swallowing?

    <p>Epiglottis (A)</p> Signup and view all the answers

    What anatomical regions comprise the pharynx?

    <p>Nasopharynx, oropharynx, and laryngopharynx (D)</p> Signup and view all the answers

    What is a hallmark feature of the cricoid cartilage?

    <p>Indicates a possible site for tracheotomy (C)</p> Signup and view all the answers

    What is the primary function of the ventricular folds in the larynx?

    <p>To hold breath against pressure in the thoracic cavity (D)</p> Signup and view all the answers

    How do the vocal folds create sound?

    <p>By vibrating when air flows between them (A)</p> Signup and view all the answers

    What impact do androgens have on the vocal folds?

    <p>They make folds thicker and longer, affecting pitch (A)</p> Signup and view all the answers

    What is the primary structural change in the bronchi as they branch out?

    <p>Incomplete cartilage rings become plates and disappear (A)</p> Signup and view all the answers

    Where is the most sensitive area for triggering the cough reflex located?

    <p>At the carina of the trachea (B)</p> Signup and view all the answers

    Which layer of the trachea is primarily responsible for its structural integrity?

    <p>Hyaline cartilage (B)</p> Signup and view all the answers

    What role does the sympathetic autonomic nervous system (ANS) play in the bronchi?

    <p>It promotes relaxation and dilation (D)</p> Signup and view all the answers

    What is the relationship between bronchial structure and the autonomic nervous system?

    <p>The parasympathetic system causes constriction while the sympathetic leads to dilation (B)</p> Signup and view all the answers

    What is the formula for calculating minute ventilation (MV)?

    <p>MV = breaths/min x tidal volume (D)</p> Signup and view all the answers

    What percentage of tidal volume typically reaches the respiratory zone in healthy adults?

    <p>70% (B)</p> Signup and view all the answers

    Which of the following best defines vital capacity?

    <p>Tidal volume plus inspiratory and expiratory reserve volumes (D)</p> Signup and view all the answers

    What does Dalton’s Law state about gases in a mixture?

    <p>Each gas contributes to total pressure based on its partial pressure. (A)</p> Signup and view all the answers

    What is the function of anatomical (respiratory) dead space?

    <p>Conducts air but does not participate in gas exchange (B)</p> Signup and view all the answers

    In respiratory physiology, what is the significance of the alveolar ventilation rate?

    <p>It indicates the volume of air actually reaching the respiratory zone per minute. (D)</p> Signup and view all the answers

    Which volume of air is considered to be residual volume?

    <p>Air remaining in the lungs after a forceful exhalation (D)</p> Signup and view all the answers

    What typically occurs to the rate of gas diffusion when the difference in partial pressures increases?

    <p>The rate of diffusion increases. (B)</p> Signup and view all the answers

    Flashcards

    What makes up the upper respiratory system?

    The upper respiratory system consists of structures like the nose, pharynx, and associated parts. It is responsible for bringing air into the body and for filtering and warming the air.

    What makes up the lower respiratory system?

    The lower respiratory system includes the larynx, trachea, bronchi, and lungs. These structures transport air to the lungs for gas exchange.

    What is the conducting zone?

    The conducting zone of the respiratory system carries air from the nose to the lungs. It includes the nose, pharynx, larynx, trachea, bronchi, bronchioles, and terminal bronchioles.

    What is the respiratory zone?

    The respiratory zone is the primary area where gas exchange occurs. It includes the respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli.

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    What is the external nose?

    The external nose is the visible part of the nose on your face.

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    What is the internal nose?

    The internal nose is a large cavity located beyond the nasal vestibule. It houses the internal nares, which connect to the pharynx.

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    What is the pharynx?

    The pharynx is a passageway for both air and food. It is located behind the nasal cavity and extends to the larynx. It also plays a role in sound resonance.

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    What is the larynx?

    The larynx, also known as the voice box, is a short passage that connects the laryngopharynx to the trachea. It is composed of cartilage, and it houses the vocal cords.

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    What are the ventricular folds?

    Pair of folds in the larynx superior to the vocal folds; functions in holding breath against pressure in the chest cavity.

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    What are the vocal folds?

    Pair of folds in the larynx which vibrate and produce sound with air when contracted by muscles; can move apart or together, elongate or shorten, and become tighter or looser.

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    What effect do androgens have on vocal folds?

    Hormonal influence that makes vocal folds thicker and longer, resulting in a slower vibration and lower pitch.

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    What is the trachea?

    A tube that extends from the larynx to the superior border of the 5th thoracic vertebra (T5), dividing into the right and left primary bronchi.

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    What are the four layers of the trachea?

    The four layers composing the trachea are mucosa, submucosa, hyaline cartilage, and adventitia.

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    What is the structure of the tracheal cartilage?

    16-20 incomplete rings of hyaline cartilage that reinforce the trachea; the open part faces the esophagus.

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    What is the carina?

    The internal ridge that marks the point where the trachea divides into the right and left primary bronchi; a highly sensitive area for triggering the cough reflex.

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    Explain the bronchial tree

    The branching network of airways from the trachea into the lungs, consisting of primary, secondary, tertiary, and terminal bronchi, and bronchioles.

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    What is the pleural membrane?

    A double-layered membrane that encloses each lung. The outer layer, the parietal pleura, lines the thoracic cavity, while the inner layer, the visceral pleura, covers the lung itself.

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    What is the pleural cavity?

    A fluid-filled space between the two layers of the pleural membrane. This fluid reduces friction and helps the lungs stick together, allowing them to expand and contract easily.

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    What is the cardiac notch?

    A notch on the left lung where the heart sits, making the left lung slightly smaller than the right lung.

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    What are alveoli?

    These are small, balloon-like structures in the lungs where gas exchange takes place. They come in two types: Type I cells form the majority of the lining and are responsible for gas exchange, while Type II cells secrete surfactant which reduces surface tension and prevents the alveoli from collapsing.

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    What are the lobes of the lungs?

    Lobes are divisions within the lungs, each receiving its own bronchus. Each lobe is further divided into lobules, which are small compartments containing a lymphatic vessel, arteriole, venule, and a branch of the terminal bronchiole.

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    Henry's Law

    The amount of a gas dissolved in a liquid is directly proportional to its partial pressure and solubility. Higher partial pressure of a gas over a liquid and higher solubility lead to more gas dissolved.

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    Decompression Sickness (The Bends)

    A condition that occurs when dissolved gases, usually nitrogen, come out of solution in the blood due to rapid pressure changes, forming bubbles that can block blood vessels and cause pain, numbness, and other symptoms.

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    Oxygen Diffusion in External Respiration

    Oxygen diffuses from the alveoli (higher P O2) into the blood of the pulmonary capillaries (lower P O2). This continues until the PO2 of the capillary blood matches the PO2 of the alveolar air.

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    Carbon Dioxide Diffusion in External Respiration

    Carbon dioxide diffuses from deoxygenated blood in the pulmonary capillaries (higher PCO2) into the alveolar air (lower PCO2). This continues until the PCO2 of the blood reaches 40 mmHg.

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    What is minute ventilation (MV)?

    The total volume of air inhaled and exhaled each minute.

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    What is alveolar ventilation rate?

    The volume of air that reaches the respiratory zone of the lungs per minute.

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    What is the anatomic (respiratory) dead space?

    The conducting airways that carry air but do not participate in gas exchange.

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    What is vital capacity?

    The maximum volume of air that can be exhaled after a maximum inspiration.

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    What is residual volume?

    The amount of air left in the lungs after a forceful exhalation.

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    What is Dalton's Law?

    Each gas in a mixture of gases exerts its own pressure as if no other gases were present.

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    What is partial pressure (Px)?

    The pressure of a specific gas in a mixture of gases.

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    How does gas diffusion work in the lungs?

    Gas diffuses across a permeable membrane from the region of higher partial pressure to the region of lower partial pressure.

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    What is the diaphragm's role in inhalation?

    The primary muscle responsible for inhalation, it flattens and lowers its dome during contraction.

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    What is the role of the external intercostals during inhalation?

    Contracting these muscles elevates the ribs, contributing to the expansion of the chest cavity.

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    What is lung elastic recoil?

    The tendency of the lungs to recoil to their original size due to elastic fibers and surface tension, facilitating passive exhalation.

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    What is the surface tension of alveolar fluid?

    A feature of the alveoli that helps prevent collapse during exhalation and contributes to lung elastic recoil.

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    What is lung compliance?

    The ease with which lungs and chest wall can expand, influenced by elasticity and surface tension.

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    What is airway resistance?

    The resistance to airflow in the respiratory system, primarily influenced by the diameter of the bronchioles.

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    What drives airflow in the respiratory system?

    The pressure difference between the lungs and the atmosphere that drives airflow.

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    How does active exhalation differ from passive exhalation?

    Active exhalation uses muscles to force air out of the lungs, unlike passive exhalation which relies on elastic recoil.

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    Study Notes

    Chapter 23: The Respiratory System

    • This chapter covers the anatomy and physiology of the respiratory system.
    • The structural components are categorized into upper and lower respiratory systems.
    • Upper respiratory system parts include the nose, pharynx, and associated structures.
    • Lower respiratory system parts include the larynx, trachea, bronchi, and lungs.
    • The functional components are categorized as conducting zone and respiratory zone.
    • Conducting zone components include the structures that transport air to the lungs (nose, pharynx, larynx, trachea, bronchi, bronchioles, and terminal bronchioles).
    • Respiratory zone components are structures involved in gas exchange (respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli).

    Nose

    • External nose - visible exterior portion of the nose.
    • Internal nose - large cavity beyond the nasal vestibule.
    • Internal nares (choanae) - Internal openings of the nasal cavity.
    • Ducts from paranasal sinuses and nasolacrimal ducts open into the nasal cavity.
    • Nasal cavity is divided by the nasal septum.
    • Nasal conchae subdivide the cavity into meatuses, increasing surface area and preventing dehydration.
    • Olfactory receptors are in the olfactory epithelium.

    Pharynx

    • Starts at internal nares and extends to the cricoid cartilage of the larynx.
    • Skeletal muscle contraction during swallowing aids in deglutition.
    • Functions as a passageway for air and food.
    • It's a resonating chamber.
    • Tonsils are housed in the pharynx.
    • 3 anatomical regions: nasopharynx, oropharynx, and laryngopharynx.

    Larynx

    • Short passageway connecting the laryngopharynx to the trachea.
    • Composed of 9 pieces of cartilage.
    • Thyroid cartilage (Adam's apple).
    • Cricoid cartilage is essential for tracheotomy.
    • Epiglottis closes off the glottis during swallowing.
    • Glottis includes vocal folds (true vocal cords) and rima glottidis (space).
    • Cilia in the upper respiratory tract move mucus and particles downward toward the pharynx.
    • Cilia in the lower respiratory tract move mucus upward.

    Structures of Voice Production

    • Mucous membranes (false vocal cords).
    • Function in holding breath against pressure in the thoracic cavity.
    • Vocal folds (true vocal cords).
    • Muscle contraction stretches vocal folds into the airway to create sound vibrations.
    • Androgens (male hormones) make folds thicker and longer, leading to lower pitch.

    Trachea

    • Extends from the larynx to the superior border of T5.
    • Divides into the right and left primary bronchi.
    • 4 layers: mucosa, submucosa, hyaline cartilage, adventitia.
    • 16-20 C-shaped rings of hyaline cartilage.
    • Open part of the rings faces the esophagus.

    Bronchi

    • Right and left primary bronchi lead to the right lung.
    • Carina is an internal ridge that triggers the cough reflex.
    • Branches of bronchi form a bronchial tree.
    • Structural changes occur with branching (Incomplete cartilage rings, plates, muscles).
    • Sympathetic nervous system dilates; parasympathetic constricts bronchioles.

    Lungs

    • Separated by the heart and other mediastinum structures.
    • Each lung has a double-layered pleural membrane.
    • Parietal pleura lines the thoracic cavity wall.
    • Visceral pleura covers the lungs themselves.
    • Pleural fluid reduces the friction between layers.
    • Cardiac notch - heart makes the left lung slightly smaller than the right lung.

    Alveoli

    • Cup-shaped outpouching, 2 or more alveoli sharing a common opening.
    • 2 types of alveolar epithelial cells:
    • Type I alveolar cells form a nearly continuous lining, facilitating gas exchange (major).
    • Type II alveolar cells secrete alveolar fluid (surfactant), reducing the tendency of alveoli to collapse.

    Respiratory Membrane

    • Alveolar wall (Type I and Type II alveolar cells).
    • Epithelial basement membrane.
    • Capillary basement membrane.
    • Capillary endothelium.
    • Thin structure facilitating gas diffusion.
    • Lungs receive blood from pulmonary arteries (deoxygenated) and bronchial arteries (oxygenated).

    Pulmonary Ventilation

    • Respiration steps include pulmonary ventilation, external respiration, and internal respiration.
    • Pulmonary ventilation is inhalation and exhalation, moving air between the atmosphere and alveoli.
    • External respiration exchanges gases between alveoli and blood.
    • Internal respiration exchanges gases between systemic capillaries and tissue cells.

    Inhalation

    • Pressure inside the alveoli must become lower than atmospheric pressure.
    • Achieved by increasing the size of the lungs (Boyle's law).
    • Diaphragm and external intercostals contract to increase lung volume and decrease pressure.

    Exhalation

    • Pressure in the lungs is higher than atmospheric pressure.
    • Normally a passive process, muscles relax.
    • Elastic recoil of the chest wall and lungs, and surface tension of alveolar fluid is responsible for decreasing volume and increasing pressure.

    Airflow

    • Air pressure difference drives airflow.
    • Factors affecting airflow include surface tension of alveolar fluid, lung compliance, and airway resistance.

    Lung Volumes and Capacities

    • Minute ventilation (MV) - total volume of air inhaled and exhaled each minute (about 6 liters/minute in a healthy adult).
    • Tidal volume - volume of air moved in and out of the lungs during a single breath (about 500ml).

    Exchange of Oxygen and Carbon Dioxide

    • Gases exert pressure in a mixture of gases as if no other gases are present (Dalton's Law).
    • Partial pressure of a gas is the pressure that gas exerts individually.
    • Total pressure is the sum of all partial pressures.
    • Gases diffuse down their pressure gradients.

    Henry's Law

    • Quantity of gas dissolved in a liquid is proportional to the partial pressure of the gas and its solubility.

    External Respiration

    • Oxygen diffuses from alveolar air (high partial pressure) into blood in pulmonary capillaries (low partial pressure).
    • Carbon dioxide diffuses from blood in pulmonary capillaries (high partial pressure) to alveolar air (low partial pressure).

    Internal Respiration

    • Oxygen diffuses from systemic capillary blood into tissue cells (low partial pressure).
    • Carbon dioxide diffuses from tissue cells to systemic capillaries (high partial pressure).

    Transport of Oxygen

    • Oxygen is mostly bound to hemoglobin (98.5%) inside red blood cells.
    • Hemoglobin's heme portion contains 4 iron atoms, each binding one oxygen molecule.
    • Oxyhemoglobin can release oxygen to cells.

    Transport of Carbon Dioxide

    • CO2 is transported dissolved in plasma, bound to hemoglobin, or as bicarbonate ions.
    • A majority of CO2 is transported as bicarbonate ions (about 70%).
    • Enzyme carbonic anhydrase forms carbonic acid (H2CO3), which dissociates into H+ and HCO3-.
    • The chloride shift moves chloride ions in and out of red blood cells to maintain ionic balance.

    Relationship between Hemoglobin and Oxygen

    • Fully saturated hemoglobin combines to oxyhemoglobin.
    • Percent saturation represents the average oxygen saturation of hemoglobin.
    • Oxygen-hemoglobin dissociation curve shows the relationship between oxygen partial pressure and hemoglobin saturation.

    Other Factors Affecting Hemoglobin Affinity for Oxygen

    • Factors affecting hemoglobin's affinity for oxygen include acidity (Bohr effect), partial pressure of carbon dioxide (Bohr effect), and temperature.

    Bohr Effect

    • As acidity (pH) decreases, hemoglobin's affinity for oxygen decreases.
    • Increasing acidity (lower pH) enhances oxygen unloading from hemoglobin.
    • Increased PCO2 also shifts the oxyhemoglobin dissociation curve to the right and enhances oxygen unloading.

    Temperature Changes Affecting Hemoglobin Oxygen Affinity

    • Higher temperatures decrease hemoglobin's affinity for oxygen, and unloading also promotes at higher temperatures.
    • During hypothermia (low temperature), hemoglobin's affinity for oxygen is increased, hindering oxygen unloading.
    • 2,3-bisphosphoglycerate (BPG) formed by red blood cells during glycolysis helps unload oxygen by binding to hemoglobin.

    Fetal and Maternal Hemoglobin

    • Fetal hemoglobin has a higher oxygen affinity than adult hemoglobin, facilitating the transfer of oxygen from maternal to fetal blood.

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