Respiratory Immune System Quiz

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Questions and Answers

What is the major part of respiratory defense included in the innate immune response?

Sneezing

Fever

Cough (correct)

Nasal congestion

What is the aim of the lung microbiome in the respiratory tract?

Maintain immune tolerance (correct)

Induce aberrant inflammation

Prevent antimicrobial peptide secretion

Increase susceptibility to infection

Which of the following is NOT a non-specific secreted factor in the respiratory tract?

Mucus

Collectins

Antimicrobial peptides

Histamines (correct)

What is essential for moving captured material, including pathogens, out of the lung?

Cilia and mucociliary transport Signup and view all the answers

What type of tissue is NOT included in the immune tissue of the respiratory tract?

Adenoids Signup and view all the answers

What does the respiratory tract epithelium need to balance in response to environmental debris?

Immune response with infection control Signup and view all the answers

What affects prevention of respiratory tract infections and vaccination response?

Age-related changes in immune response Signup and view all the answers

What impairs mucociliary clearance, increasing susceptibility to infection and disease?

Destruction of cilia Signup and view all the answers

Which cells in the respiratory tract sample the lung environment and present antigens to naïve T cells?

Dendritic cells Signup and view all the answers

What is the primary immunodeficiency associated with low IgA levels and potential respiratory and GI infections?

Selective IgA deficiency (SIgAD) Signup and view all the answers

Which cells play a major role in clearing pulmonary surfactant?

Alveolar macrophages Signup and view all the answers

What is the function of nasal-associated lymphoid tissue (NALT)?

Contain immune cells that induce immune responses and activate memory cells Signup and view all the answers

Which cells form tight barriers with tight and adherens junctions in the respiratory tract?

Epithelial cells Signup and view all the answers

What is the role of antibodies IgA and IgG in mucosal immunity?

Play a key role in mucosal immunity Signup and view all the answers

Which cells dispose of inhaled microbes and suppress aberrant inflammation in the lungs?

Resident macrophages Signup and view all the answers

What is the mechanism of IgA transcytosis across mucosal epithelial surfaces?

Mediated by the poly-Ig receptor (pIgR) Signup and view all the answers

What is the function of Type II pneumocytes in alveolar epithelium?

Secrete surfactant proteins and cytokines Signup and view all the answers

What leads to recruitment of immune cells and activation of adaptive immune response in the respiratory tract?

Recognition of microbial pathogens by PRRs Signup and view all the answers

Study Notes

Respiratory Immune System Overview

Epithelial cells form tight barriers with tight and adherens junctions
Ciliated columnar cells aid in mucociliary transport and secrete antimicrobial factors
Type II pneumocytes in alveolar epithelium secrete surfactant proteins and cytokines
Resident macrophages in the lungs dispose of inhaled microbes and suppress aberrant inflammation
Alveolar macrophages play a major role in clearing pulmonary surfactant
Dendritic cells in the respiratory tract sample the lung environment and present antigens to naïve T cells
Recognition of microbial pathogens by PRRs leads to recruitment of immune cells and activation of adaptive immune response
Nasal-associated lymphoid tissue (NALT) contains immune cells that induce immune responses and activate memory cells
Antibodies IgA and IgG play a key role in mucosal immunity
Selective IgA deficiency (SIgAD) is a primary immunodeficiency associated with low IgA levels and potential respiratory and GI infections
IgA transcytosis is mediated by the poly-Ig receptor (pIgR) across mucosal epithelial surfaces
The germinal center reaction involves B cells undergoing somatic hypermutation and affinity maturation, and interaction with Tfh cells to induce class switching and differentiation

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Description

Test your knowledge of the respiratory immune system with this quiz. Explore the role of epithelial cells, macrophages, dendritic cells, and antibodies in defending the respiratory tract. Learn about conditions like selective IgA deficiency and the mechanisms of mucosal immunity.