L4 Development of Ureter and Urinary (P2 Hard)

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Questions and Answers

What is the embryonic origin of the epithelium lining the bladder?

  • Ectoderm of the vesicourethral canal
  • Splanchnic mesenchyme
  • Endoderm of the urogenital sinus (correct)
  • Mesoderm of the allantois

At what age does the bladder begin its descent into the greater pelvis?

  • At 1 year
  • At 6 years (correct)
  • At puberty
  • At birth

From which part of the urogenital sinus does the female urethra develop?

  • Vesicourethral canal
  • Phallic part
  • Pelvic part (correct)
  • Vesical part

Which congenital anomaly of the ureter involves the ureter ascending posterior to the inferior vena cava?

<p>Retrocaval ureter (C)</p> Signup and view all the answers

What structure does the metanephric diverticulum elongate to form?

<p>Ureter (A)</p> Signup and view all the answers

What are urachal cysts remnants of?

<p>Epithelial lining of the urachus (B)</p> Signup and view all the answers

Which part of the urogenital sinus develops into the urinary bladder?

<p>Cranial vesical part (A)</p> Signup and view all the answers

Which part of the male urethra is derived from the phallic part of the urogenital sinus?

<p>Penile urethra (C)</p> Signup and view all the answers

What does the urachus become after the bladder detaches from the allantois?

<p>Urachal cord (A)</p> Signup and view all the answers

How many times do the buds from each calyx continue to subdivide during kidney development?

<p>12 or more times (C)</p> Signup and view all the answers

What type of tissue develops the smooth muscles of the bladder?

<p>Mesoderm (B)</p> Signup and view all the answers

What is formed from the absorption of the caudal ends of the mesonephric ducts into the wall of the bladder?

<p>Ureters (B)</p> Signup and view all the answers

What primarily causes the ureters to increase in length during their development?

<p>Migration of the kidneys upwards (C)</p> Signup and view all the answers

What is the outer fold developing from the edges of the phallic part of the urogenital sinus called?

<p>Genital fold (C)</p> Signup and view all the answers

Which embryological structure divides the cloaca into the rectum and the urogenital sinus?

<p>Urorectal septum (B)</p> Signup and view all the answers

Which condition reflects an abnormal widening of the ureter, measuring more than 8mm?

<p>Megalo-ureter (B)</p> Signup and view all the answers

Which part of the urogenital sinus is responsible for the development of the middle section of the urethra?

<p>Middle pelvic part (D)</p> Signup and view all the answers

What is the first structure that the metanephric diverticulum arises from?

<p>Mesonephric duct (A)</p> Signup and view all the answers

The expanded cranial end of the metanephric diverticulum forms which structure?

<p>Renal pelvis (C)</p> Signup and view all the answers

What eventually happens to the major calyces during ureter development?

<p>They form new buds (A)</p> Signup and view all the answers

What condition involves a remnant of the lumen that typically remains in the inferior part of the urachus?

<p>Urachal Sinus (C)</p> Signup and view all the answers

Which condition is characterized by the entire urachus remaining patent, allowing urine to escape from the umbilicus?

<p>Urachal Fistula (B)</p> Signup and view all the answers

In which condition does the posterior bladder wall protrude through a defect in the anterior abdominal wall below the umbilicus?

<p>Ectopia vesica (A)</p> Signup and view all the answers

Which congenital anomaly of the urethra involves the external urethral orifice appearing on the ventral surface of the penis?

<p>Hypospadias (A)</p> Signup and view all the answers

Which condition describes the external urethral orifice situated on the dorsal surface of the penis?

<p>Epispadias (C)</p> Signup and view all the answers

What is a rare condition that allows urine escape from the umbilicus due to a patent urachus?

<p>Urachal Fistula (B)</p> Signup and view all the answers

Which of the following conditions is NOT related to abnormalities of the urachus?

<p>Hypospadias (B)</p> Signup and view all the answers

What results when there is a defect in the anterior abdominal wall, leading to the exposure of the trigone of the bladder?

<p>Ectopia vesica (D)</p> Signup and view all the answers

Which condition may lead to dribbling of urine due to exposure of the ureteric orifices?

<p>Ectopia vesica (C)</p> Signup and view all the answers

Which congenital anomaly is defined as a connection between the rectum and the urethra?

<p>Congenital Recto-urethral Fistula (B)</p> Signup and view all the answers

Flashcards

Urachal Sinus

A remnant of the urachus, a tube that connects the bladder to the umbilicus during fetal development. It usually persists as a small, inferior portion of the urachus.

Urachal Fistula

A condition where the entire urachus remains open, creating a connection between the bladder and the umbilicus, allowing urine to leak out.

Ectopia Vesica

A condition where the posterior bladder wall protrudes through a defect in the anterior abdominal wall below the umbilicus exposing the trigone of the bladder and ureteric orifices.

Hypospadias

A condition in which the external urethral orifice is located on the ventral side of the penis, instead of the tip.

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Epispadias

A condition in which the external urethral orifice is located on the dorsal side of the penis, instead of the tip.

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Congenital Recto-Urethral Fistula

An abnormal connection between the rectum and the urethra.

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Trigone of the Bladder

The triangular region at the base of the bladder formed by the caudal ends of the mesonephric ducts.

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Epithelium of the Bladder

The inner layer of the bladder, derived from the endoderm of the vesical part of the urogenital sinus.

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Smooth Muscle of the Bladder

The smooth muscle layer of the bladder, developing from mesoderm adjacent to the bladder.

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Urachus

The remnant of the allantois, a tube connecting the bladder to the umbilicus during embryonic development.

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Ureterocele

An abnormal outpouching of the ureter as it enters the bladder.

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Bifid Renal Pelvis and Ureter

A partial or complete failure of the metanephric diverticulum to separate, resulting in a double renal pelvis and ureter.

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Retrocaval Ureter

The ureter ascends behind the inferior vena cava, causing potential complications.

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Megalo-ureter

The ureter becomes wider than 8 mm, potentially impairing urine flow.

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Urachal Cyst

A cyst formed from remnants of the epithelial lining of the urachus.

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Proximal Prostatic Urethra

The part of the male urethra derived from the lower part of the vesicourethral canal.

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What is the metanephric diverticulum?

The metanephric diverticulum, also known as the ureteric bud, is an outgrowth from the mesonephric duct near its entrance into the cloaca. It's crucial for forming the ureter, renal pelvis, and collecting tubules.

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How does the ureteric bud develop into the ureter?

The ureteric bud elongates dorsally and then cranially, forming the ureter, a tube connecting the kidney to the bladder. Its cranial end forms a funnel-shaped renal pelvis, which further splits into major and minor calyces.

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How does the renal pelvis form?

The expanded cranial end of the ureteric bud dilates to form the renal pelvis, a funnel-shaped structure. This pelvis further splits into major calyces, which in turn form minor calyces. This intricate network collects urine from the nephrons.

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What forms the minor calyces?

The minor calyces are formed through continuous subdivision of the major calyces. These small structures collect urine from the nephrons, the functional units of the kidney.

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How do the mesonephric ducts and ureters connect to the bladder?

The caudal ends of the mesonephric ducts are absorbed into the wall of the bladder. This means the mesonephric ducts and lower ureters connect separately to the bladder.

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What forms the main part of the urinary bladder?

The urinary bladder develops from the vesical part of the urogenital sinus. This part forms the main portion of the bladder.

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What separates the cloaca into the rectum and urogenital sinus?

The urorectal septum, a dividing wall, separates the cloaca into the dorsal rectum and ventral urogenital sinus. This septum develops at the junction of the allantois and hindgut, growing towards the cloacal membrane.

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How is the urogenital sinus divided?

The urogenital sinus is divided into three parts: the cranial vesical part, which forms the bladder; the middle pelvic part, which forms the urethra; and the caudal phallic part, which forms the external genitalia.

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What is the cloaca?

The cloaca is the dilated caudal part of the hindgut, composed of endodermal cells. This structure plays a crucial role in the early development of the urinary and digestive systems.

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How does the urethra develop?

The development of the urethra involves the middle part of the urogenital sinus, which elongates and differentiates into the urethra. The urethra further divides into various segments.

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Study Notes

AL AZHAR UNIVERSITY

  • Faculty of Medicine for Girls
  • Year 2, Semester 3
  • Academic year: 2023/2024
  • Module Name: Renal module
  • Code: IPM-07-20318
  • Credit hours: 5
  • Anatomy & Embryology department

Development of the Ureter, Urinary Bladder & Urethra

  • Intended Learning Outcomes (ILOs):

    • Describe the development of the ureter and its congenital anomalies.
    • Understand the development of the urinary bladder and its congenital anomalies.
    • Describe the development of the urethra and differentiate between its congenital anomalies.
  • Ureter Development:

    • The urogenital system develops from the intermediate mesoderm.
    • The metanephric diverticulum (ureteric bud) is an outgrowth from the mesonephric duct near the cloaca.
    • It elongates dorsally and then cranially.
    • The stalk becomes the ureter.
    • The expanded cranial end forms the funnel-shaped renal pelvis.
    • The renal pelvis divides into two portions, forming the major calyces.
    • The calyces further subdivide repeatedly (up to 12 or more times).
  • Urinary Bladder Development:

    • The urinary bladder develops from two sources.
      • The vesical part of the urogenital sinus.
      • The caudal ends of the mesonephric ducts (form the trigon).
    • The bladder's epithelium is derived from the endoderm of the vesical part of the urogenital sinus.
    • Smooth muscles develop from adjacent mesoderm.
  • Urethra Development:

    • Female Urethra: Entire urethra derived from endoderm of the urogenital sinus. Connective tissue and smooth muscle are derived from splanchnic mesenchyme.
    • Male Urethra: The proximal part of the prostatic urethra, extending to the ejaculatory ducts, is derived from the vesicourethral canal. The distal part (including the membranous part) of the prostatic urethra is derived from the pelvic part of the urogenital sinus. The greater part of the penile urethra is derived from the phallic part of the urogenital sinus. The part of the penile urethra in the glans penis is derived from the surface ectoderm.
  • Urogenital Membrane

    • Develops on each side of the phallic part of the urogenital sinus.
    • Inner fold (urethral fold) unites to form the majority of the urethra.
    • Outer fold (genital fold) fuses to create the scrotum.
    • The urogenital membrane is the ventral portion of the cloaca membrane
    • It closes the phallic part of the urogenital sinus inferiorly.

Congenital Anomalies

  • Ureter:

    • Bifid renal pelvis and ureter: Incomplete division of the metanephric diverticulum.
    • Retrocaval ureter: Ureter passes posterior to the inferior vena cava.
    • Megalo-ureter: Ureter significantly widened (over 8 mm).
    • Ureterocele: Outpouching of the ureter as it enters the bladder.
  • Urinary Bladder:

    • Urachal cysts: Cysts formed from remnants of the urachus.
    • Urachal sinus: Remnants of the urachal lumen often persists.
    • Urachal fistula: Patent urachus allows urine to escape from the umbilicus.
  • Urethra:

    • Hypospadias: Abnormal (ventral) opening of the urethra.
    • Epispadias: Abnormal (dorsal) opening of the urethra.
    • Congenital recto-urethral fistula: Abnormal connection between the rectum and the urethra.

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