L4 Development of the ureter and urinary (P1 Mid)

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Questions and Answers

What is the primary source of the urogenital system's development?

  • Ectoderm
  • Intermediate mesoderm (correct)
  • Endoderm
  • Mesothelial layer

What is the function of the metanephric diverticulum (ureteric bud) in the development of the ureter?

  • It creates major calyces only.
  • It forms the urinary bladder.
  • It develops the mesonephric ducts.
  • It elongates and becomes the ureter. (correct)

Which part of the cloaca contributes to the urinary bladder's formation?

  • Ventral urogenital sinus (correct)
  • Dorsal rectum
  • Cloacal membrane
  • Hindgut diverticulum

How does the renal pelvis form during ureter development?

<p>By the dilation of the expanded cranial end of the ureteric bud. (B)</p> Signup and view all the answers

Which structure is formed from the urogenital sinus during bladder development?

<p>Vesical part (C)</p> Signup and view all the answers

What happens to the mesonephric ducts during the development process?

<p>They are absorbed into the wall of the bladder. (B)</p> Signup and view all the answers

What is the role of the urorectal septum in developing the cloaca?

<p>It divides the cloaca into dorsal and ventral parts. (D)</p> Signup and view all the answers

How many times may the new buds from each calyx subdivide during development?

<p>12 or more times (B)</p> Signup and view all the answers

What is the caudal phallic part of the urogenital sinus responsible for?

<p>It fosters growth toward the genital tubercle. (B)</p> Signup and view all the answers

What primarily distinguishes the major calyces in ureter development?

<p>Their growth from the renal pelvis. (A)</p> Signup and view all the answers

What structure forms the urachus after becoming a thick fibrous cord?

<p>Allantois (B)</p> Signup and view all the answers

Which embryonic tissue contributes to the development of the smooth muscles of the bladder?

<p>Mesoderm (A)</p> Signup and view all the answers

At what age does the urinary bladder begin to enter the greater pelvis?

<p>At 6 years (C)</p> Signup and view all the answers

Which part of the male urethra is derived from the pelvic part of the urogenital sinus?

<p>Distal prostatic urethra (A), Proximal prostatic urethra (B)</p> Signup and view all the answers

What anomaly occurs due to the incomplete division of the metanephric diverticulum?

<p>Bifid renal pelvis and ureter (B)</p> Signup and view all the answers

From which part of the urogenital sinus is the entire female urethra derived?

<p>Urogenital sinus (A)</p> Signup and view all the answers

What is a potential cystic anomaly that can occur related to the urachus?

<p>Urachal cysts (D)</p> Signup and view all the answers

Which fold unites to form the greater part of the male urethra?

<p>Urethral fold (D)</p> Signup and view all the answers

What is the role of the outer fold known as the genital fold?

<p>Unite to form the scrotum (B)</p> Signup and view all the answers

The part of the penile urethra in the glans of the penis is derived from which tissue?

<p>Ectoderm (A)</p> Signup and view all the answers

What describes a urachal fistula?

<p>The urachus remains patent, allowing urine escape (B)</p> Signup and view all the answers

Which congenital anomaly results in the urethral opening being on the ventral surface of the penis?

<p>Hypospadias (A)</p> Signup and view all the answers

What condition is characterized by the posterior bladder wall protruding through a defect in the abdominal wall?

<p>Ectopia vesica (B)</p> Signup and view all the answers

Which congenital condition is very rare and allows urine to escape from the umbilicus?

<p>Urachal fistula (A)</p> Signup and view all the answers

In which condition does the external urethral orifice appear on the dorsal surface of the penis?

<p>Epispadias (B)</p> Signup and view all the answers

A congenital recto-urethral fistula generally results in which of the following complications?

<p>Abnormal urine flow (C)</p> Signup and view all the answers

Which anatomical structure is predominantly involved in the development of urachal conditions?

<p>Urachus (D)</p> Signup and view all the answers

What condition characteristically exposes the trigone of the bladder?

<p>Ectopia vesica (D)</p> Signup and view all the answers

What is a notable characteristic of a urachal sinus?

<p>Remnant of the lumen in the inferior urachus (A)</p> Signup and view all the answers

Flashcards

Urachal Sinus

A remnant of the lumen of the urachus that persists in the inferior part of the urachus.

Urachal Fistula

The entire urachus remains patent, creating a connection between the bladder and the umbilicus, allowing urine to escape from the umbilicus.

Ectopia Vesica

A condition where the posterior bladder wall protrudes through a defect in the anterior abdominal wall, below the umbilicus.

Hypospadias

The external urethral orifice is located on the ventral (underside) surface of the penis.

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Epispadias

The external urethral orifice is situated on the dorsal (upper) surface of the penis.

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Congenital Recto-Urethral Fistula

An abnormal connection between the urethra and the rectum.

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Urachal Anomalies

A failure of the urachus to close completely during fetal development.

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Metanephric diverticulum (ureteric bud)

An outgrowth from the mesonephric duct near its entrance into the cloaca, which develops into the ureter, renal pelvis, major and minor calyces, and collecting tubules.

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Patent Urachus

The urachus completely fails to close, forming a tube between the bladder and the navel.

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Ureter

The stalk of the metanephric diverticulum that elongates dorsally and cranially.

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Urachal Cyst

A cyst forms within the urachus, filled with fluid.

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Renal pelvis

The funnel-shaped structure at the top of the ureter, formed by the expanded cranial end of the ureteric bud.

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Major calyces

Divisions of the renal pelvis that collect urine from multiple minor calyces.

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Urachal Sinus

The urachus remains open only at the navel, creating a small opening at the belly button.

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Minor calyces

Smaller divisions of the renal pelvis that collect urine from the collecting tubules.

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Cloaca

The dilated caudal part of the hindgut, comprised of endodermal cells, which is divided into the rectum and the urogenital sinus.

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Urorectal septum

A septum that divides the cloaca into the rectum and the urogenital sinus.

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Urogenital sinus

The ventral part of the cloaca that develops into the urinary bladder and urethra.

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Vesical (vesicourethral) part of the urogenital sinus

The cranial part of the urogenital sinus that forms the main part of the urinary bladder.

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Oblique entry of ureters into the bladder

As the kidneys ascend, the ureters lengthen and their orifices enter the bladder obliquely through the base, preventing urine reflux from the bladder back into the ureters.

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Development of the Urinary Bladder

The caudal ends of the mesonephric ducts form the trigon of the bladder. The epithelium of the bladder is derived from the endoderm of the vesical part of the urogenital sinus. The smooth muscles develop from adjacent mesoderm.

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Urachus

The bladder is continuous with the allantois, when it becomes thick fibrous cord it is called urachus. The urachus extends from the apex of the bladder to the umbilicus.

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Position of the Urinary Bladder

In infants and children, the urinary bladder, is in the abdomen. It enters the greater pelvis at 6 years of age. It enters the lesser pelvis at puberty.

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Development of Female Urethra

The entire female urethra is derived from endoderm of the urogenital sinus. The connective tissue and smooth muscle are derived from splanchnic mesenchyme.

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Development of Male Urethra: Proximal and Distal Parts

The proximal part of the prostatic urethra (as far as, the opening of the ejaculatory ducts) derived from the lower part of the vesicourethral canal. The distal part of the prostatic urethra +membranous part are derived from pelvic part of the urogenital sinus.

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Development of Male Urethra: Penile Parts

The greater part of the penile urethra derived from the phallic part of the urogenital sinus. The part of penile urethra in the glans of the penis is derived from the surface ectoderm

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Formation of the Urethra and Scrotum

2 Folds develop from the edges of the phallic part of the urogenital sinus on each side of the urogenital membrane. The inner fold called urethral fold that unite from behind forwards to form the greater part of the urethra. The outer fold called genital fold that unite form the scrotum.

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Urogenital Membrane

The urogenital membrane is the ventral part of the cloaca membrane. It closes the phallic part of the urogenital sinus inferiorly.

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Bifid Renal Pelvis and Ureter

Incomplete division of the metanephric diverticulum leads to a bifid renal pelvis and ureter.

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Retrocaval Ureter

The ureter ascends posterior to the inferior vena cava.

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Study Notes

AL AZHAR UNIVERSITY - Anatomy & Embryology

  • Faculty: Medicine for Girls
  • Year: 2, Semester 3
  • Academic Year: 2023/2024
  • Module Name: Renal module
  • Code: IPM-07-20318
  • Credit Hours: 5
  • Topic: Development of the Ureter, Urinary Bladder & Urethra

Intended Learning Outcomes (ILOs)

  • ILO 1: Describe the development of the ureter and its congenital anomalies.
  • ILO 2: Understand the development of the urinary bladder and its congenital anomalies.
  • ILO 3: Describe the development of the urethra and differentiate between its congenital anomalies.

Development of the Ureter

  • The urogenital system develops from the intermediate mesoderm.
  • The metanephric diverticulum (ureteric bud) arises as an outgrowth from the mesonephric duct, entering the cloaca.
  • It grows dorsally and cranially.
  • The stalk of the ureteric bud becomes the ureter.
  • The expanded cranial end of the bud forms the funnel-shaped renal pelvis.
  • The renal pelvis divides into two, then into multiple parts, forming the major and minor calyces.
  • These structures repeatedly divide, eventually creating the collecting ducts and renal tubules.

Development of the Urinary Bladder

  • The urinary bladder develops from two sources.
  • The vesical part of the urogenital sinus forms the main part of the bladder.
  • The caudal ends of the mesonephric ducts form the trigone of the bladder.
  • The epithelium of the bladder originates from the endoderm of the vesical part of the urogenital sinus.
  • The smooth muscles of the bladder develop from adjacent mesoderm.

Development of the Urethra

  • In females, the entire urethra is derived from the endoderm of the urogenital sinus.
  • Connective tissue and smooth muscle derive from the splanchnic mesenchyme.
  • In males, the proximal part of the prostatic urethra (as far as the ejaculatory ducts) is formed from the vesicourethral part of the urogenital sinus.
  • The distal part and membranous parts of the prostatic urethra originate from the pelvic part of the urogenital sinus.
  • The greater part of the penile urethra arises from the phallic part of the urogenital sinus.
  • The glans of the penis is formed from surface ectoderm.

Urogenital Membrane

  • There are two folds developing from the edges of the phallic part of the urogenital sinus.
  • An inner fold, the urethral fold, forms the major part of the urethra.
  • An outer fold, the genital fold, forms the scrotum in males and the labia in females.
  • The urogenital membrane represents the ventral portion of the cloaca membrane.
  • It eventually closes, incorporating the phallic part of the urogenital sinus.

Congenital Anomalies

  • Ureter: Bifid renal pelvis and ureter, Retrocaval ureter, Megalo-ureter, Ureterocele
  • Bladder: Urachal cysts, Urachal sinus, Urachal fistula
  • Urethra: Hypospadias, Epispadias, Congenital recto-urethral fistula

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