Renal Cell Carcinoma Quiz
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Questions and Answers

What is the predominant origin of renal cell carcinoma?

  • Renal interstitial tissue
  • Urothelial epithelium
  • Pelvic epithelium
  • Renal tubular epithelium (correct)

Which age group is most commonly affected by renal cell carcinoma?

  • Fifth to seventh decades (correct)
  • Eighth decade and beyond
  • Adolescence
  • Childhood

What is the characteristic histological feature of clear cell carcinomas?

  • High inflammation with necrosis
  • Large cystic structures with encapsulation
  • Small round cells with dense cytoplasm
  • Polygonal cells with abundant clear cytoplasm (correct)

Which factor is NOT recognized as a risk factor for renal cell carcinoma?

<p>Chronic liver disease (A)</p> Signup and view all the answers

How does clear cell carcinoma typically spread hematogenously?

<p>Via the renal vein into the IVC (D)</p> Signup and view all the answers

Which characteristic feature is associated with Chromophobe Renal Carcinomas?

<p>Multiple chromosome losses and extreme hypodiploidy (C)</p> Signup and view all the answers

What is the primary age group most affected by Wilms tumor?

<p>Children aged 2 to 5 years (C)</p> Signup and view all the answers

Which is a common extrarenal effect associated with Rinal Neoplasms?

<p>Polycythemia due to erythropoietin production (C)</p> Signup and view all the answers

What histological features are observed in Wilms tumor?

<p>Triphasic features including blastema, immature stroma, and epithelial cell types (B)</p> Signup and view all the answers

What percentage of Wilms tumors are associated with WT1 mutations?

<p>Less than 10% (D)</p> Signup and view all the answers

Flashcards

Renal Cell Carcinoma

A type of kidney cancer originating from the renal tubular epithelium. It accounts for 80 to 85 percent of primary malignant kidney neoplasms.

Clear Cell Carcinomas

The most common type of renal cell carcinoma, often associated with genetic syndromes.

VHL Gene and Clear Cell Carcinoma

The VHL gene is implicated in both familial and sporadic clear cell carcinomas. It is a key player in the development of this type of kidney cancer.

Papillary Renal Cell Carcinomas

A type of renal cell carcinoma characterized by papillary, or finger-like, projections. It can be either familial or sporadic.

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MET Proto-oncogene

This proto-oncogene, when mutated, can contribute to the development of familial papillary renal cell carcinoma.

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Chromophobe Renal Carcinoma

A type of kidney cancer that occurs in 5% of renal cell cancers. It's characterized by a slow growth rate and good prognosis.

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Triad of Symptoms in Chromophobe Renal Carcinoma

A distinctive clinical presentation of Chromophobe Renal Carcinoma. It usually involves painless blood in urine, a palpable mass in the abdomen and dull pain in the flank.

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Paraneoplastic Syndrome

A group of symptoms caused by cancer cells that produce hormones. It can lead to high calcium levels, high blood pressure, Cushing's syndrome, or feminization or masculinization.

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Wilms Tumor

The most common childhood kidney cancer, usually affecting children between 2 and 5 years old. It involves abnormal development of kidney cells.

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Triphasic Histologic Features of Wilms Tumor

A unique feature of Wilms tumors where different types of kidney cells are present in the tumor, representing different developmental stages of the kidney.

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