Podcast
Questions and Answers
What is the male to female ratio for renal cell carcinoma (RCC)?
What is the male to female ratio for renal cell carcinoma (RCC)?
The male to female ratio for RCC is approximately 5:2 to 3:1.
What are some of the key predisposing factors for developing renal cell carcinoma?
What are some of the key predisposing factors for developing renal cell carcinoma?
Key predisposing factors include smoking, obesity, hypertension, and exposure to heavy metals.
Describe von Hippel–Lindau (VHL) syndrome and its association with RCC.
Describe von Hippel–Lindau (VHL) syndrome and its association with RCC.
VHL syndrome is a hereditary condition predisposing individuals to multiple neoplasms, including multicentric bilateral renal cell carcinomas.
What genetic mutation is associated with hereditary leiomyomatosis and renal cell cancer syndrome?
What genetic mutation is associated with hereditary leiomyomatosis and renal cell cancer syndrome?
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What is the significance of the MET proto-oncogene in hereditary papillary RCC?
What is the significance of the MET proto-oncogene in hereditary papillary RCC?
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What percentage of all cancers does renal cell carcinoma (RCC) represent?
What percentage of all cancers does renal cell carcinoma (RCC) represent?
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Identify one environmental exposure that is a predisposing factor for RCC.
Identify one environmental exposure that is a predisposing factor for RCC.
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Name a hereditary syndrome associated with bilateral renal cysts and RCC.
Name a hereditary syndrome associated with bilateral renal cysts and RCC.
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What is the common genetic alteration linked to hereditary leiomyomatosis and renal cell cancer syndrome?
What is the common genetic alteration linked to hereditary leiomyomatosis and renal cell cancer syndrome?
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What kind of carcinoma is primarily associated with the mutation in the MET proto-oncogene?
What kind of carcinoma is primarily associated with the mutation in the MET proto-oncogene?
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Study Notes
Renal Cell Carcinoma (RCC)
- RCC accounts for 90% of primary kidney cancers and 2-3% of all cancers.
- Also known as hypernephroma due to its resemblance to adrenal cortex cells.
- Originates from renal tubular epithelium (renal adenocarcinomas).
Epidemiology and Predisposing Factors
- Male to female ratio is 5:2 to 3:1.
- Predisposing factors:
- Smoking
- Obesity
- Hypertension
- Unopposed estrogen therapy
- Exposure to asbestos, cadmium, petroleum products, and heavy metals
- Acquired cystic kidney disease in dialysis patients
Genetic Predisposition to RCC
- Most RCC cases are sporadic.
- 5% are inherited and associated with:
-
von Hippel–Lindau (VHL) syndrome:
- Multiple neoplasms (especially haemangioblastomas of cerebellum and retina)
- Multiple bilateral renal cysts
- Pheochromocytomas
- Multicentric bilateral RCC
-
Hereditary leiomyomatosis and renal cell cancer syndrome:
- Autosomal dominant inheritance
- Mutation in Fumarate Hydratase (FH) gene
- Uterine and cutaneous leiomyomas
- Aggressive papillary RCC
-
Hereditary papillary RCC:
- Autosomal dominant inheritance
- Multiple cytogenetic abnormalities
- Mutation in MET proto-oncogene
- Multiple bilateral papillary RCCs
-
Birt–Hogg–Dube (BHD) syndrome:
- Autosomal dominant inheritance
- Mutation in the BHD gene (encoding folliculin)
- Skin appendageal tumors (hair follicle origin)
- Pulmonary cysts
- Renal tumors
-
von Hippel–Lindau (VHL) syndrome:
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Description
This quiz covers Renal Cell Carcinoma (RCC), detailing its epidemiology, predisposing factors, and genetic predisposition. Explore key information regarding risk factors, genetic conditions associated with RCC, and the importance of understanding this common kidney cancer.
