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Regulation of Gluconeogenesis

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Questions and Answers

What is the main inhibitory hormone for gluconeogenesis?

Glucocorticoids

Adrenaline

Insulin (correct)

Glucagon

How does insulin affect the activity of key gluconeogenic enzymes?

Decreases their activity (correct)

Has no effect on them

Halts their production

Increases their activity

Which hormone is the primary stimulatory hormone for promoting gluconeogenesis during fasting?

Insulin

Thyroid hormone

Glucagon (correct)

Estrogen

What effect do glucocorticoids have on gluconeogenesis?

Both stimulate and inhibit (B) Signup and view all the answers

Which enzyme's activity is decreased by insulin to suppress gluconeogenesis?

Glucose-6-phosphatase (D) Signup and view all the answers

How does glucagon increase the availability of gluconeogenic precursors?

Stimulates breakdown of glycogen (B) Signup and view all the answers

What effect do metabolites like fructose-2,6-bisphosphate (F2,6BP) and AMP have on gluconeogenesis?

F2,6BP inhibits a key enzyme while AMP inhibits another enzyme (C) Signup and view all the answers

How does limited substrate availability impact gluconeogenesis?

Limited substrates hinder the process of gluconeogenesis (A) Signup and view all the answers

What role does gene expression play in the regulation of gluconeogenesis?

Gene expression influences the transcription of enzymes involved in gluconeogenesis (D) Signup and view all the answers

Which factor can induce the transcription of genes encoding enzymes for gluconeogenesis?

Glucagon (A) Signup and view all the answers

How do hormones like glucagon impact the regulation of gluconeogenesis?

Glucagon induces gene expression for enzymes aiding in gluconeogenesis (A) Signup and view all the answers

What effect do allosteric regulators have on the enzymes in gluconeogenesis?

Allosteric regulators inhibit enzyme activity in specific steps of gluconeogenesis (B) Signup and view all the answers