Regulation of Enzymes in Glycolysis and Gluconeogenesis
18 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which term is used to describe the dynamic steady state of a living cell?

  • Isotonic state
  • Eutrophic state
  • Homeorhesis
  • Homeostasis (correct)
  • What happens when the concentration of AMP in a cell is much lower compared to ATP and ADP?

  • AMP production is favored upon ATP depletion (correct)
  • The cell's energetic state is stabilized
  • AMP-dependent kinases are inhibited
  • ATP production is prioritized over AMP
  • What role does AMP-dependent kinase (AMPK) play in response to changes in a cell's energetic state?

  • Stabilizes ATP levels
  • Inhibits protein phosphorylation
  • Activates glycogen synthase
  • Promotes metabolic fluxes through multiple pathways (correct)
  • Why are steps 2 and 3 considered near equilibrium in a reaction according to the text?

    <p>Due to the similarity in forward and reverse rates</p> Signup and view all the answers

    What happens when glycogen synthase dissociates from the particle in glycogen metabolism?

    <p>Chain extension stops</p> Signup and view all the answers

    How does a change in external circumstances or energy supply impact the homeostasis of a living cell?

    <p>It triggers intrinsic regulatory mechanisms in pathways</p> Signup and view all the answers

    What is the relationship between high ATP concentrations and the rate of fructose 1,6-bisphosphate formation in glycolysis?

    <p>High ATP concentrations lead to low fructose 1,6-bisphosphate formation rate.</p> Signup and view all the answers

    What regulates the activation of Glycogen Synthase by dephosphorylating it?

    <p>Glucose 6-phosphate and glucose in surplus</p> Signup and view all the answers

    Which hormone inhibits the dephosphorylation of Glycogen Synthase by inactivating PP1?

    <p>Epinephrine</p> Signup and view all the answers

    What causes the association of glycogen phosphorylase with other proteins, including PP1?

    <p>Glycogen targeting protein GM</p> Signup and view all the answers

    Which signaling pathway turns off GSK by phosphorylating it?

    <p>Glucagon (starvation signal)</p> Signup and view all the answers

    What stimulates the dephosphorylation of Glycogen Synthase during glucose surplus?

    <p>Glucose 6-phosphate and glucose itself</p> Signup and view all the answers

    What is the primary function of isozymes that catalyze the same reaction?

    <p>They provide redundancy and differential regulation.</p> Signup and view all the answers

    How does the sequestration of hexokinase IV by a nuclear binding protein affect enzyme activity?

    <p>It decreases hexokinase IV activity when glucose concentration is high.</p> Signup and view all the answers

    What effect does a high ATP concentration have on PFK activity?

    <p>Decreases the K0.5 value for fructose 6-phosphate binding.</p> Signup and view all the answers

    Why is it important to regulate hexokinase IV and not operate it simultaneously with other hexokinases?

    <p>To prevent futile energy loss.</p> Signup and view all the answers

    What is the primary difference between metabolic regulation and metabolic control?

    <p>Regulation maintains homeostasis, while control responds to external signals.</p> Signup and view all the answers

    What role does isozyme regulation play in metabolic pathways?

    <p>It controls the direction and speed of metabolic flux.</p> Signup and view all the answers

    More Like This

    Cortisol and Glucose Regulation Quiz
    10 questions
    Glycolysis and Gluconeogenesis Flashcards
    28 questions
    Glycolysis and Gluconeogenesis Quiz
    16 questions
    Use Quizgecko on...
    Browser
    Browser