Y1S2 008 I Biochem Regulation of Calcium Levels by Hormones
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Questions and Answers

What is the primary function of Parathyroid Hormone (PTH)?

  • Regulating thyroid hormone production
  • Maintaining plasma [Ca2+] levels (correct)
  • Regulating inorganic phosphate concentration
  • Controlling extracellular fluid pH

How many amino acids are present in the intact Parathyroid Hormone (PTH)?

  • 84 (correct)
  • 150
  • 115
  • 90

What is the approximate half-life of intact Parathyroid Hormone (PTH) in the blood?

  • 10-12 minutes
  • 5-6 minutes
  • 1-2 minutes
  • 3-4 minutes (correct)

What is the approximate total weight of parathyroid tissue in the body?

<p>150 mg (D)</p> Signup and view all the answers

What is the role of Calcitonin in regulating calcium concentration in the extracellular fluid?

<p>Minor role (C)</p> Signup and view all the answers

How many parathyroid glands are usually found in the human body?

<p>4 (A)</p> Signup and view all the answers

What is the primary effect of PTH on osteoclasts?

<p>Stimulation of osteoclast development (B)</p> Signup and view all the answers

What is the active metabolite of vitamin D3?

<p>1,25-DHCC (C)</p> Signup and view all the answers

Where is the 1α-hydroxylase enzyme located?

<p>Proximal convoluted tubules of the nephrons (C)</p> Signup and view all the answers

What is the effect of PTH on plasma calcium levels?

<p>Increase in plasma calcium levels (A)</p> Signup and view all the answers

What is the precursor of cholecalciferol?

<p>7-hydrocholesterol (B)</p> Signup and view all the answers

What is the net result of PTH actions on bone?

<p>Increase in bone resorption (B)</p> Signup and view all the answers

What directly stimulates the activity of 1α-hydroxylase?

<p>PTH and hypophosphataemia (B)</p> Signup and view all the answers

What is the role of calbindin-D in the intestinal mucosa?

<p>Promotes the absorption of calcium and phosphate (C)</p> Signup and view all the answers

What is the effect of calcitriol on bone mobilization?

<p>Stimulates bone resorption (C)</p> Signup and view all the answers

What is the function of osteocalcin in bone formation?

<p>Is a marker of bone formation and turnover (B)</p> Signup and view all the answers

What is the role of alkaline phosphatase in bone formation?

<p>Is involved in the formation of new bone (B)</p> Signup and view all the answers

What is the effect of 1:25-DHCC on 25-HCC?

<p>Stimulates its hydroxylation (C)</p> Signup and view all the answers

What is the effect of calcitonin on osteoclast activity?

<p>It inhibits osteoclast activity (B)</p> Signup and view all the answers

What is the primary target cell for calcitonin?

<p>Osteoclast (C)</p> Signup and view all the answers

What is the effect of calcitonin on renal reabsorption of calcium and phosphate?

<p>It reduces renal reabsorption of calcium and phosphate (A)</p> Signup and view all the answers

During which periods is plasma calcitonin elevated?

<p>During pregnancy and lactation (B)</p> Signup and view all the answers

What is the mechanism by which calcitonin acts on its target cells?

<p>Via increased cAMP concentrations (B)</p> Signup and view all the answers

What is the effect of calcitonin on osteoblastic activity?

<p>It increases osteoblastic activity (A)</p> Signup and view all the answers

What is the most common single presenting complaint of Primary Hyperparathyroidism?

<p>Renal stones (C)</p> Signup and view all the answers

What is the primary cause of Hypercalcemia in Primary Hyperparathyroidism?

<p>Combined effects of PTH-induced bone resorption, intestinal calcium absorption, and renal tubular reabsorption (C)</p> Signup and view all the answers

What is the most serious complication of Primary Hyperparathyroidism?

<p>Deposition of calcium in the kidney tubules (B)</p> Signup and view all the answers

What is the underlying cause of Secondary Hyperparathyroidism?

<p>Hypocalcemia and associated hypertrophy of the glands (D)</p> Signup and view all the answers

What is the result of the reduction of renal production of 1,25-dihydroxycholecalciferol (1,25-DHCC)?

<p>Hyperphosphaturia (D)</p> Signup and view all the answers

What is the characteristic of the disorder in Primary Hyperparathyroidism?

<p>Hypercalcemia, hypophosphatemia, and hyperphosphaturia (B)</p> Signup and view all the answers

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