Podcast
Questions and Answers
Which of the following is a key difference between physiological and reparative regeneration?
Which of the following is a key difference between physiological and reparative regeneration?
- Physiological regeneration involves scar formation, while reparative regeneration does not.
- Physiological regeneration is injury-induced, while reparative regeneration is a natural, episodic process.
- Physiological regeneration requires a blastema, while reparative regeneration does not.
- Physiological regeneration is a natural, episodic process, while reparative regeneration is injury-induced. (correct)
Scar tissue fully restores both the structure and mechanical function of the original tissue.
Scar tissue fully restores both the structure and mechanical function of the original tissue.
False (B)
What is the role of positional memory in regenerating cells?
What is the role of positional memory in regenerating cells?
to ensure they regenerate the correct structures in the correct location
A collection of proliferating, lineage-restricted progenitor cells that forms during regeneration is called a regeneration ______.
A collection of proliferating, lineage-restricted progenitor cells that forms during regeneration is called a regeneration ______.
Match each organism with its unique regenerative capability:
Match each organism with its unique regenerative capability:
In bone regeneration, what is the role of BMP7?
In bone regeneration, what is the role of BMP7?
In axolotl limb regeneration, skin cells can differentiate into muscle cells within the blastema.
In axolotl limb regeneration, skin cells can differentiate into muscle cells within the blastema.
Where does the tail break occur in leopard geckos during tail regeneration?
Where does the tail break occur in leopard geckos during tail regeneration?
Which of the following characteristics distinguishes reparative regeneration from dysfunctional repair?
Which of the following characteristics distinguishes reparative regeneration from dysfunctional repair?
Rapid leopard gecko tail regeneration is faster than the tails initial growth during ______
Rapid leopard gecko tail regeneration is faster than the tails initial growth during ______
Flashcards
Physiological Regeneration
Physiological Regeneration
Natural loss and replacement of cells/tissues.
Reparative Regeneration
Reparative Regeneration
Replacement of cells/tissues due to injury.
Regeneration Blastema
Regeneration Blastema
A collection of proliferating progenitor cells that are lineage-restricted.
Dysfunctional Repair: Scars
Dysfunctional Repair: Scars
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Reparative Regeneration
Reparative Regeneration
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Axolotl Blastema Cells
Axolotl Blastema Cells
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Leopard Gecko Tail Regeneration
Leopard Gecko Tail Regeneration
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Positional Memory
Positional Memory
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Bone Regeneration
Bone Regeneration
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Study Notes
- Regeneration is the natural replacement of lost cells and tissues.
- Physiological regeneration involves natural, episodic loss and replacement.
- Reparative regeneration is the injury-induced replacement of cells and tissues.
- Regenerating cells and tissues possess positional memory, which guides their development.
- Regeneration requires coordinated interaction between progenitor cells and a permissive environment.
- A regeneration blastema is a collection of proliferating lineage-restricted progenitor cells.
Dysfunctional Repair
- Scars are an example of dysfunctional repair.
- Scars partially restore structure and mechanical function but are ultimately dysfunctional, disfiguring, and prevent regeneration.
- The collagen arrangement in scars reduces flexibility compared to normal tissue.
- Scars represent points of weakness with less structural integrity than surrounding tissue.
Reparative Regeneration Requirements
- Requires hemostasis with limited inflammation.
- Does not result in scars.
- Proliferation of blastema cells is essential.
- Positional memory guides regeneration.
- Exhibits a level-specific response.
- In humans, the distal 1/3 of a phalanx can regenerate.
- Mice can regenerate bones, soft connective tissues, blood vessels, and nails in their limbs.
Bone Regeneration
- Direct bone formation occurs without a cartilaginous precursor.
- Beads can act as microcarriers for delivering growth factors to stimulate regeneration.
- Control beads without growth factors do not induce regeneration themselves.
- BMP7-coated beads can induce bone regeneration.
Limb Regeneration Examples
- Axolotl blastema cells remember their tissue of origin; skin cells create new skin, and muscle cells create new muscle.
- Leopard geckos exhibit rapid tail regeneration, faster than the initial tail growth during development.
- Tail breaks occur within a tail vertebra.
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