21 Questions
Which of the following is a factor to consider when evaluating the plausibility of lab results?
Physiological possibility
What is the percentage likelihood of a healthy patient sitting outside a three standard deviation limit?
0.13%
When can using an analyser with poor precision be problematic?
When there is a small differentiation between two populations
Which of the following factors can affect lab results?
Haemolysis, icterus, and lipemia
What is a common recommendation for determining the reference interval for enzyme activities?
Multiples of the upper limit
Why is it important to consider sensitivity and specificity when using diagnostic cut-offs?
To avoid false positives and false negatives
Which of the following is true about the ideal reference interval generation?
It is based on a large group of clinically normal animals
What is the definition of a reference interval?
The range of values that includes 95% of the healthy population
How are abnormal results in profiles defined?
Results that sit outside of the reference interval
What percentage of the healthy population have abnormal results?
5%
What is the meaning of results slightly outside of the reference interval?
They could represent the small percentage of healthy animals
What are the yellow lines in the normal distribution graph?
A single deviation from the mean
What is the chance of getting just one result outside of the reference interval in a panel of 15 tests?
More than half of healthy animals will have one or more slightly abnormal results
What is the statistical definition of the reference intervals?
Mean plus 2 standard deviations for normal distribution, 2.5th to 97.5th percentile for skewed distribution
According to the text, what are the two routes to profile interpretation?
Step-by-step and pattern match
What is the purpose of constructing a differential list for each abnormality in the step-by-step method?
To narrow down the list of potential causes
What is the recommended approach to reviewing the results initially?
Review the results as if you haven't seen the case
What is the significance of normal results in profile interpretation?
They rule out many possible causes of presentation
What is the purpose of dividing the profile into sensible groups of tests?
To categorize the tests for easier interpretation
What is the value of normal results in profile interpretation?
They help rule out many possible causes of presentation
What should be considered when trying to explain the findings in profile interpretation?
The presence of comorbidities
Test Your Knowledge on Generating Ideal Reference Intervals for Lab Results. Take this quiz to see how well you understand the process of determining normal or abnormal lab results. Learn about the factors considered, such as age, breed, and the size of the sample group. Discover how reference intervals are defined and why they are important in assessing overall health.
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