Podcast
Questions and Answers
What processes account for the degradation of red blood cells after their lifespan of 120 days?
What processes account for the degradation of red blood cells after their lifespan of 120 days?
What is the first product formed during the breakdown of heme in the macrophages?
What is the first product formed during the breakdown of heme in the macrophages?
Where is bilirubin transported after its formation in macrophages?
Where is bilirubin transported after its formation in macrophages?
What component is NOT released from heme during RBC degradation?
What component is NOT released from heme during RBC degradation?
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What role do agglutinogens serve in the context of red blood cells?
What role do agglutinogens serve in the context of red blood cells?
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Study Notes
Red Blood Cell (RBC) Lifespan and Breakdown
- RBCs have a lifespan of 120 days.
- 90% of damaged or dead RBCs are engulfed by macrophages.
- 10% of RBCs hemolyze (burst open) in the plasma.
- Macrophages break down the engulfed RBCs.
- Digestive enzymes from lysosomes break RBCs into pieces.
- Amino acids and iron (Fe2+) are released.
- Iron and amino acids are recycled to create new RBCs in bone marrow.
- Heme is broken down into biliverdin, then bilirubin.
- Bilirubin is transported to the liver.
- Bilirubin is excreted in bile.
RBC Breakdown Location
- Macrophages in the spleen and liver are the primary sites for RBC degradation.
- 10% of dead/damaged RBCs hemolyse in plasma, and are collected and cleared by the kidneys.
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Description
Explore the fascinating lifecycle of red blood cells (RBCs), including their lifespan, breakdown processes, and recycling of important components. This quiz delves into the mechanisms by which macrophages, digestive enzymes, and other body systems work together to manage RBC turnover.
