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Questions and Answers
Which type of receptors have inbuilt enzymatic activity?
Which type of receptors have inbuilt enzymatic activity?
- Metabotropic receptors
- Catalytic receptors (correct)
- Ion channel receptors
- G-protein coupled receptors
What is the location of the ligand-binding domain in receptor tyrosine kinases?
What is the location of the ligand-binding domain in receptor tyrosine kinases?
- Extracellular side (correct)
- Intracellular side
- Both extracellular and intracellular sides
- None of the above
Which growth factors can bind to receptor tyrosine kinases?
Which growth factors can bind to receptor tyrosine kinases?
- Serotonin
- Insulin (correct)
- GABA
- Dopamine
What is the structure of receptor tyrosine kinases?
What is the structure of receptor tyrosine kinases?
What are the tyrosine residues in receptor tyrosine kinases?
What are the tyrosine residues in receptor tyrosine kinases?
Which domain is located on the extracellular side of receptor tyrosine kinases?
Which domain is located on the extracellular side of receptor tyrosine kinases?
What is the enzymatic activity of catalytic receptors called?
What is the enzymatic activity of catalytic receptors called?
Which type of receptors are receptor tyrosine kinases?
Which type of receptors are receptor tyrosine kinases?
Which growth factor can bind to receptor tyrosine kinases?
Which growth factor can bind to receptor tyrosine kinases?
Where is the tyrosine kinase domain located in receptor tyrosine kinases?
Where is the tyrosine kinase domain located in receptor tyrosine kinases?
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Study Notes
Receptor Tyrosine Kinases
- Receptor tyrosine kinases (RTKs) are a type of receptor that has inbuilt enzymatic activity.
- The ligand-binding domain in RTKs is located on the extracellular side.
- RTKs can bind to various growth factors, including epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and fibroblast growth factor (FGF).
- RTKs have a specific structure, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain.
- The tyrosine residues in RTKs are phosphorylated upon ligand binding, leading to the activation of downstream signaling pathways.
- The enzymatic activity of RTKs is called tyrosine kinase activity.
- RTKs are a type of catalytic receptor, which means they have inbuilt enzymatic activity.
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