Recent Innovations in Sterile Dosage Forms
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Questions and Answers

What shape of discosomes may enhance their effectiveness in ocular drug delivery?

  • Cube
  • Disc (correct)
  • Cylinder
  • Sphere
  • Which of the following is a significant drawback of using ocular inserts?

  • Low effectiveness
  • Their high viscosity
  • Frequent administration required
  • Being non-biodegradable (correct)
  • In liposomal drug formulations, what is a benefit of using fatty acid esters?

  • Improving respiratory hormone metabolism
  • Prolonging steroid retention in the respiratory tract (correct)
  • Increasing drug toxicity
  • Enhancing drug solubility
  • What is a characteristic of the ocusert system for controlled drug release?

    <p>Provides zero-order kinetic release</p> Signup and view all the answers

    What type of drugs have been reported to be delivered using liposome technology for pulmonary use?

    <p>Antibiotics</p> Signup and view all the answers

    What is a key characteristic of the lipid component in proliposomes?

    <p>It has a phase transition temperature below 37°C.</p> Signup and view all the answers

    What is the function of cochleates in drug delivery systems?

    <p>They create a protective barrier against enzymatic degradation.</p> Signup and view all the answers

    What is the typical size of the particles used for inhaled dry insulin powders?

    <p>Between 0.1 µm to 5 µm.</p> Signup and view all the answers

    How are respirable particles produced in the micro and nanoparticulate DPI compositions?

    <p>By spray-drying or freeze spray drying followed by comminution.</p> Signup and view all the answers

    What is a potential application of the nanoparticulates used in pulmonary delivery systems?

    <p>Sustained release of antigens like DNA or proteins.</p> Signup and view all the answers

    Which of the following ions is critical in the formation of cochleates?

    <p>Ca2+</p> Signup and view all the answers

    What is the primary benefit of the DPI formulations discussed in the context of treating anthrax infection?

    <p>They ensure rapid encapsulation and effective drug delivery.</p> Signup and view all the answers

    What is the primary purpose of coating ganciclovir pellets with PVA?

    <p>To create a controlled release mechanism</p> Signup and view all the answers

    Which form of AmBisome is used for intravenous infusion?

    <p>Sterile, nonpyrogenic lyophilized product</p> Signup and view all the answers

    What is the advantage of pegylation in Doxil's formulation?

    <p>It protects liposomes from the mononuclear phagocyte system</p> Signup and view all the answers

    What characterizes DepoFoam technology?

    <p>It uses lipid bilayers in a honeycomb structure</p> Signup and view all the answers

    What is the significance of DepoDur in surgical pain management?

    <p>It maintains effective morphine levels for 48 hours</p> Signup and view all the answers

    DaunoXome is specifically formulated for what purpose?

    <p>To maximize daunorubicin selectivity for solid tumors</p> Signup and view all the answers

    How does the release mechanism of DepoFoam occur post-injection?

    <p>Through reorganization of lipid membranes and pore formation</p> Signup and view all the answers

    What is one of the primary characteristics of Doxil’s formulation?

    <p>It incorporates methoxypolyethylene glycol on the liposome surface</p> Signup and view all the answers

    What was notable about DepoCyt in the market?

    <p>It was the first product using DepoFoam technology</p> Signup and view all the answers

    What is the primary purpose of biodegradable implants like Zoladex?

    <p>To deliver continuous drug release over a specified period</p> Signup and view all the answers

    Which of the following is a characteristic of implantable osmotic pumps?

    <p>They utilize a collapsible bag to manage drug release.</p> Signup and view all the answers

    What is the indication for the Gliadel Wafer implant?

    <p>Adjunct treatment for high-grade malignant brain tumors</p> Signup and view all the answers

    How does LACRISERT function in the treatment of dry eye disorders?

    <p>It serves as a sustained release artificial tear insert.</p> Signup and view all the answers

    Which compound is found in the matrix of the Zoladex implant?

    <p>D, L-lactic and glycolic acid copolymer</p> Signup and view all the answers

    What is a unique feature of the Gliadel Wafer in its application post-surgery?

    <p>It slowly dissolves to release medication directly at the tumor site.</p> Signup and view all the answers

    What distinguishes vapor pressure moderated implantable devices from other types of implants?

    <p>They utilize a propellant for drug delivery.</p> Signup and view all the answers

    Which condition does VITRASERT specifically target?

    <p>Cytomegalovirus (CMV) retinitis</p> Signup and view all the answers

    What role do phagocytes play in the immune response?

    <p>They engulf and digest harmful particles.</p> Signup and view all the answers

    Study Notes

    Recent Innovations in Sterile Dosage Forms

    • Sterile dosage forms are free from microorganisms, pathogens, and spores. They are mainly injected or applied to the eye or intranasally.

    Content

    • The presentation outlines different types of sterile dosage forms and the need for innovative approaches.

    • It discusses Ophthalmic, Intranasal & Pulmonary Drug Delivery, Implants, Parenteral, and Other sterile dosage forms.

    What are sterile dosage forms?

    • A sterile dosage form is free from all types of microbial contamination.
    • Sterile products are generally injected, applied to the eye, or administered intranasally.

    What is the need to develop innovative sterile dosage forms?

    • To reduce administration frequency.
    • To enhance bioavailability.
    • To reduce side effects.
    • To target drug delivery.
    • To maintain stability of potent drugs.
    • To control the release of potent drugs.
    • To enhance patient compliance.
    • To reduce the frequency of administration.

    Types of sterile dosage form

    • Ophthalmic

      • Ophthalmic Insitu gels
      • Ophthalmic Cationic emulsion
      • Ophthalmic Iontophoresis
      • Ophthalmic Nanoparticle
      • Ophthalmic Discosomes
      • Ocular Inserts
    • Intranasal & Pulmonary Drug Delivery

      • Liposome and Lipid Based Formulation
      • Proliposomes
      • Nanocochleates
      • Micro and Nanoparticulates DPI Compositions
      • Delivery of Proteins, Peptides and Macromolecules
      • Matrix formation
      • Pro-drugs and pegylation
    • Implants

      • Implantable Osmotic Pumps
      • Vapor pressure moderated implantable device
      • Biodegradable device
      • Ophthalmic implant
    • Parenteral

      • Liposome Parenteral Formulation
      • Depofoam
      • Microsphere
      • Noisome
      • Nanosuspension
      • Others
    • Others

      • Prefilled-Syringe
      • Pens
      • Auto injector
      • Infusion Pump
      • Ultrasafe Passive Delivery System.

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    Description

    This quiz explores the latest advancements in sterile dosage forms, which are essential for safe drug delivery via injections, ophthalmic use, and intranasal administration. It covers various types of sterile dosage forms and innovative methods designed to enhance drug efficacy and patient compliance. Test your knowledge on the importance and evolution of these crucial pharmaceutical innovations.

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