18 Questions
What is the mechanism of action of ramelteon?
Melatonin receptor agonist
Which peptide is involved in the control of wakefulness and targeted by suvorexant?
Orexin B
Which neurotransmission does ramelteon not directly affect?
GABAergic
What is the primary indication for ramelteon?
Insomnia characterized by difficulty in sleep-onset
What type of circadian rhythm disturbances is ramelteon effective for treating?
Jet lag or work-shift sleep disorder
Which of the following is NOT a side effect of ramelteon?
Nightmares
What is the teratogenicity category for most barbiturates?
Category D
Which benzodiazepine antagonist has a short half-life due to rapid hepatic clearance?
Flumazenil
In terms of teratogenicity, what category are Ramelteon, Zaleplon, and Zolpidem classified under?
Category C
Which of the following drugs can enhance CNS depression when used concomitantly with sedative-hypnotics?
Antihypertensive agents
What is the main MOA of Flumazenil when used as an antagonist?
High affinity to benzodiazepine receptors
Which drug class does Flumazenil specifically block the effects of?
Benzodiazepines
Which drug is the active S enantiomer of zopiclone with a longer half-life and causes less amnesia or day-after somnolence?
Eszopiclone
What is the main indication for Eszopiclone?
Long-term management of insomnia
Which drug class does Zolpidem belong to?
Hypnotics
What is the mechanism of action of Ramelteon?
Acts on MT1 receptors to promote sleep onset
Which symptom is part of the withdrawal syndrome associated with Zolpidem?
Confusion
In the brain, what role do Melatonin and Orexin play in regulating sleep?
Melatonin promotes sleep onset while Orexin shifts circadian rhythms
Learn about Ramelteon, a melatonin receptor agonist that acts on the suprachiasmatic nucleus to regulate the sleep-wake cycle and circadian rhythms in the brain. Explore its mechanism of action and effects on melatonin receptors.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
