Melatonin Receptor Agonists: Ramelteon and MOA
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Questions and Answers

What is the main function of the suprachiasmatic nucleus in the brain?

  • Controlling the circadian pacemaker (correct)
  • Increasing withdrawal symptoms
  • Inducing rebound insomnia
  • Regulating GABAergic neurotransmission

Which receptors does Ramelteon act on?

  • Orexin receptors
  • GABA receptors
  • Cholinergic receptors
  • MT1 and MT2 melatonin receptors (correct)

What distinguishes Ramelteon's effects on sleep architecture from other drugs?

  • Increases withdrawal symptoms
  • Alters GABAergic neurotransmission
  • Causes rebound insomnia
  • Reduces persistent sleep latency (correct)

Which peptides are involved in the control of wakefulness?

<p>Orexin A &amp; B (D)</p> Signup and view all the answers

What effect does loss of orexin neurons have on the body?

<p>Results in narcolepsy (A)</p> Signup and view all the answers

Which disorder is Suvorexant used to treat?

<p>Insomnia (B)</p> Signup and view all the answers

Which receptor does melatonin bind to promote the onset of sleep?

<p>MT1 (B)</p> Signup and view all the answers

What is the function of the suprachiasmatic nucleus?

<p>Coordinates circadian rhythms (B)</p> Signup and view all the answers

Which neurotransmitter system does suvorexant target?

<p>Orexin (A)</p> Signup and view all the answers

What is the primary indication for the use of ramelteon?

<p>Long-term treatment of insomnia (A)</p> Signup and view all the answers

Which drug is known for its longer half-life and causing less amnesia compared to zolpidem or benzodiazepines?

<p>Eszopiclone (B)</p> Signup and view all the answers

Which category is most benzodiazepines and barbiturates classified under in terms of teratogenicity?

<p>Category D (B)</p> Signup and view all the answers

Which of the following drugs is classified as category C in terms of teratogenicity?

<p>Zaleplon (A)</p> Signup and view all the answers

What is the half-life of flumazenil due to rapid hepatic clearance?

<p>0.7–1.3 hours (A)</p> Signup and view all the answers

Flumazenil acts as a competitive antagonist with high affinity to which receptors?

<p>Benzodiazepine receptors (D)</p> Signup and view all the answers

Which drug is used to block the effect of benzodiazepines only, not barbiturates, ethanol, or opioids?

<p>Flumazenil (C)</p> Signup and view all the answers

Which class of drugs can lead to enhanced CNS depression due to interactions with sedative-hypnotics?

<p>Antihistamines (C)</p> Signup and view all the answers

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