Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells
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Questions and Answers

What was the primary objective of this study?

  • To examine the role of DNA damage response in cancer treatment
  • To explore the radiosensitizing effect of TRPV1 channel inhibitors in cancer cells (correct)
  • To investigate the effect of TRPV1 channel inhibitors on cell growth
  • To analyze the effect of γ-rays on cell membranes

    • What was the outcome of using TRPV1 channel inhibitors in cancer cells?

  • They suppressed radiation-induced reproductive death
  • They had no significant effect on cancer cells
  • They suppressed DNA damage response and enhanced radiation-induced reproductive death (correct)
  • They enhanced DNA damage response

    • What type of cells were used in the study?

  • Human breast cancer cells
  • Mouse lung cancer cells
  • Human skin cancer cells
  • A549 human lung adenocarcinoma cells and B16 mouse melanoma cells (correct)

    • What was the purpose of irradiating the cells with γ-rays?

    <p>To induce DNA damage response</p> Signup and view all the answers

    What was the dose of γ-rays used in the study?

    <p>2.0 Gy</p> Signup and view all the answers

    What was the duration of incubation after irradiation?

    <p>30 min</p> Signup and view all the answers

    What is the primary goal of using radiosensitizers in cancer therapy?

    <p>To reduce damage to adjacent normal tissues during radiotherapy</p> Signup and view all the answers

    What is the target of radiosensitizers in cancer therapy?

    <p>DNA damage repair systems</p> Signup and view all the answers

    What type of nanoparticles are being researched as radiosensitizers to improve the efficacy of cancer radiotherapy?

    <p>Gold nanoparticles</p> Signup and view all the answers

    What is the primary issue with using fractionated-dose irradiation in cancer treatment?

    <p>DNA repair during inter-fraction intervals</p> Signup and view all the answers

    What is the role of the TRPV1 channel in response to DNA damage after γ-irradiation?

    <p>It is involved in the early responses to DNA damage</p> Signup and view all the answers

    Why were TRPV1 channel inhibitors hypothesized to have a radiosensitizing effect?

    <p>Because they can block the repair of radiation-induced cell damage</p> Signup and view all the answers

    What is the function of the TRPV1 channel in cells?

    <p>A non-selective cation channel and pain receptor</p> Signup and view all the answers

    What is the potential effect of TRPV1 channel inhibitors on cancer cells?

    <p>They increase the susceptibility of cancer cells to γ-irradiation</p> Signup and view all the answers

    What is the role of ATM in the early response to radiation-induced DNA damage?

    <p>Inducing phosphorylation of H2AX at DNA damage sites</p> Signup and view all the answers

    What type of cancer cells are often targeted by radiosensitizers?

    <p>Radioresistant hypoxic cancer cells</p> Signup and view all the answers

    What is the purpose of using radiosensitizers in cancer treatment?

    <p>To increase the effectiveness of radiation therapy</p> Signup and view all the answers

    What is the result of hypoxia in solid cancer cells?

    <p>Decreased susceptibility to radiation</p> Signup and view all the answers

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