Podcast
Questions and Answers
What is the effect of TRPV1 antagonists on pain?
What is the effect of TRPV1 antagonists on pain?
What has restricted the usefulness of TRPV1 antagonists in humans?
What has restricted the usefulness of TRPV1 antagonists in humans?
In what type of pain models have TRPV1 antagonists shown efficacy?
In what type of pain models have TRPV1 antagonists shown efficacy?
What type of animals were used to test the efficacy of TRPV1 antagonists?
What type of animals were used to test the efficacy of TRPV1 antagonists?
Signup and view all the answers
What is the mechanism of action of TRPV1 antagonists?
What is the mechanism of action of TRPV1 antagonists?
Signup and view all the answers
Study Notes
TRPV1 Antagonists and Pain Management
- TRPV1 antagonists reduce pain by blocking TRPV1 activity
- In rats, TRPV1 antagonists have been shown to be effective in reducing nociception from inflammatory and neuropathic pain models
- In humans, the major side-effect of TRPV1 antagonists is hyperthermia
- Hyperthermia limits the usefulness of TRPV1 antagonists as a treatment option
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Learn about TRPV1 antagonists and their role in reducing pain, including their effectiveness in rats and side effects in humans. Understand the limitations of TRPV1 antagonists as a treatment option.
