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Questions and Answers
What is the effect of TRPV1 antagonists on pain?
What is the effect of TRPV1 antagonists on pain?
- Have no effect on pain
- Increase pain perception
- Only effective on inflammatory pain
- Reduce pain perception (correct)
What has restricted the usefulness of TRPV1 antagonists in humans?
What has restricted the usefulness of TRPV1 antagonists in humans?
- High cost of production
- Hyperthermia as a side-effect (correct)
- Inability to cross the blood-brain barrier
- Lack of efficacy in reducing pain
In what type of pain models have TRPV1 antagonists shown efficacy?
In what type of pain models have TRPV1 antagonists shown efficacy?
- Musculoskeletal and fibromyalgia pain
- Neuropathic and inflammatory pain (correct)
- Cancer and visceral pain
- Chronic and acute pain
What type of animals were used to test the efficacy of TRPV1 antagonists?
What type of animals were used to test the efficacy of TRPV1 antagonists?
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What is the mechanism of action of TRPV1 antagonists?
What is the mechanism of action of TRPV1 antagonists?
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Study Notes
TRPV1 Antagonists and Pain Management
- TRPV1 antagonists reduce pain by blocking TRPV1 activity
- In rats, TRPV1 antagonists have been shown to be effective in reducing nociception from inflammatory and neuropathic pain models
- In humans, the major side-effect of TRPV1 antagonists is hyperthermia
- Hyperthermia limits the usefulness of TRPV1 antagonists as a treatment option
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