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TRPS1

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Questions and Answers

What is the role of TRPS1 in breast cancer?

TRPS1 acts as a suppressor gene for breast cancer and a regulator of luminal progenitor cells.
TRPS1 functions as an essential regulator for the growth and differentiation of normal mammary epithelial cells and may be involved in the development of breast cancer. (correct)
TRPS1 is a zinc finger transcription factor that has no direct involvement in breast cancer development.
TRPS1 is exclusively expressed in estrogen receptor alpha (ERα)-positive breast cancer subtypes.

What did Radvanyi et al. find in their microarray analysis of breast tumor samples?

They identified a group of 15 genes overexpressed in breast cancer, including TRPS1. (correct)
They discovered a novel marker exclusively expressed in triple-negative breast cancer (TNBC).
They found that TRPS1 is a suppressor gene for breast cancer and a regulator of luminal progenitor cells.
They observed a downregulation of TRPS1 in all breast cancer subtypes.

What is the consequence of loss of the TRPS1 gene?

It leads to the overexpression of estrogen receptor alpha (ERα) in breast cancer cells.
It can cause trichorhinophalangeal syndrome, a hereditary autosomal dominant disorder characterized by distinctive facial features and bone and joint malformations. (correct)
It results in the upregulation of luminal progenitor cells in breast tissue.
It causes the downregulation of zinc finger transcription factors in breast cancer.

What did Radvanyi et al. initially believe about TRPS1 in relation to breast cancer?

<p>They thought that TRPS1 was a suppressor gene for breast cancer and a regulator of luminal progenitor cells. (D)</p> Signup and view all the answers

What is the latest identified marker in the GATA family of zinc finger transcription factors?

<p>TRPS1 (D)</p> Signup and view all the answers