TRPS1
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Questions and Answers

What is the role of TRPS1 in breast cancer?

  • TRPS1 acts as a suppressor gene for breast cancer and a regulator of luminal progenitor cells.
  • TRPS1 functions as an essential regulator for the growth and differentiation of normal mammary epithelial cells and may be involved in the development of breast cancer. (correct)
  • TRPS1 is a zinc finger transcription factor that has no direct involvement in breast cancer development.
  • TRPS1 is exclusively expressed in estrogen receptor alpha (ERα)-positive breast cancer subtypes.
  • What did Radvanyi et al. find in their microarray analysis of breast tumor samples?

  • They identified a group of 15 genes overexpressed in breast cancer, including TRPS1. (correct)
  • They discovered a novel marker exclusively expressed in triple-negative breast cancer (TNBC).
  • They found that TRPS1 is a suppressor gene for breast cancer and a regulator of luminal progenitor cells.
  • They observed a downregulation of TRPS1 in all breast cancer subtypes.
  • What is the consequence of loss of the TRPS1 gene?

  • It leads to the overexpression of estrogen receptor alpha (ERα) in breast cancer cells.
  • It can cause trichorhinophalangeal syndrome, a hereditary autosomal dominant disorder characterized by distinctive facial features and bone and joint malformations. (correct)
  • It results in the upregulation of luminal progenitor cells in breast tissue.
  • It causes the downregulation of zinc finger transcription factors in breast cancer.
  • What did Radvanyi et al. initially believe about TRPS1 in relation to breast cancer?

    <p>They thought that TRPS1 was a suppressor gene for breast cancer and a regulator of luminal progenitor cells.</p> Signup and view all the answers

    What is the latest identified marker in the GATA family of zinc finger transcription factors?

    <p>TRPS1</p> Signup and view all the answers

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