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Questions and Answers
What is the definition of Potentially Lethal Damage (PLD)?
What is the definition of Potentially Lethal Damage (PLD)?
- Damage modifiable by postirradiation conditions
- Irreversible damage leading to cell death
- Damage repairable under normal circumstances
- Damage causing cell death under ordinary circumstances (correct)
How is PLD repair demonstrated in vivo?
How is PLD repair demonstrated in vivo?
- In density-inhibited stationary-phase cell cultures
- In mouse fibrosarcomas
- In experimental tumors with a time interval allowed between irradiation and removal (correct)
- Through drastic treatments like incubation in a balanced salt solution
What factor influences the fraction of surviving cells after irradiation in radiotherapy?
What factor influences the fraction of surviving cells after irradiation in radiotherapy?
- PLD repair (correct)
- In vitro cell survival
- DNA damage repair
- Mitosis delay
How does suboptimal growth conditions contribute to PLD repair?
How does suboptimal growth conditions contribute to PLD repair?
Which cell type exhibits a large dose-rate effect with broad shoulder and high capacity to repair sublethal radiation damage?
Which cell type exhibits a large dose-rate effect with broad shoulder and high capacity to repair sublethal radiation damage?
Which cell type undergoes apoptosis post-radiation exposure?
Which cell type undergoes apoptosis post-radiation exposure?
What reflects variations in the importance of apoptosis among different cell types?
What reflects variations in the importance of apoptosis among different cell types?
What type of brachytherapy terminology evolved from Alexander Graham Bell's 1901 proposal for implanting radioactive sources in tumors?
What type of brachytherapy terminology evolved from Alexander Graham Bell's 1901 proposal for implanting radioactive sources in tumors?
What occurs if cells are prevented from dividing for 6 hours or more after irradiation?
What occurs if cells are prevented from dividing for 6 hours or more after irradiation?
What shows limited reduction in surviving crypts due to cellular proliferation compensating for radiation-induced cell killing?
What shows limited reduction in surviving crypts due to cellular proliferation compensating for radiation-induced cell killing?
What leads to an increase in the efficiency of cell killing in HeLa cells?
What leads to an increase in the efficiency of cell killing in HeLa cells?
What type of brachytherapy includes intracavitary (LDR to HDR) and permanent interstitial implants?
What type of brachytherapy includes intracavitary (LDR to HDR) and permanent interstitial implants?
What type of cells show greater variation in slope at low dose rates?
What type of cells show greater variation in slope at low dose rates?
What type of cells exhibit a dramatic dose-rate effect from acute exposure to extended exposure?
What type of cells exhibit a dramatic dose-rate effect from acute exposure to extended exposure?
What is almost as damaging as acute exposure at 0.37 Gy per hour?
What is almost as damaging as acute exposure at 0.37 Gy per hour?
What increases survival if radiation dose is split into two fractions separated in time?
What increases survival if radiation dose is split into two fractions separated in time?
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Study Notes
Radiation Biology and Brachytherapy Techniques
- HeLa cells show moderate change in response to decreasing dose-rate due to low capacity to repair sublethal radiation damage
- Chinese hamster cells exhibit large dose-rate effect with broad shoulder and high capacity to repair sublethal radiation damage
- HeLa cells undergo apoptosis post-radiation exposure, while hamster cells rarely show apoptotic death
- Differences in the size of the shoulder in survival curves reflect variations in the importance of apoptosis among different cell types
- Survival curves for 40 human cell lines cultured in vitro show greater variation in slope at low dose rates
- Dramatic dose-rate effect observed in mouse jejunum crypt cells from acute exposure to extended exposure
- Lower dose rates result in limited reduction in surviving crypts due to cellular proliferation compensating for radiation-induced cell killing
- Decreasing dose rate from 1.54 to 0.37 Gy per hour leads to an increase in the efficiency of cell killing in HeLa cells
- Low dose rate at 0.37 Gy per hour is almost as damaging as acute exposure
- Brachytherapy terminology evolved from Alexander Graham Bell's 1901 proposal for implanting radioactive sources in tumors
- Types of brachytherapy include intracavitary (LDR to HDR) and permanent interstitial implants
- Potentially Lethal Damage Repair (PLD) occurs if cells are prevented from dividing for 6 hours or more after irradiation; Sublethal Damage Repair (SLD) increases survival if radiation dose is split into two fractions separated in time
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Description
Test your knowledge of radiation biology and brachytherapy techniques with this quiz. Explore topics such as dose-rate effects on different cell types, survival curves, cellular proliferation, and the terminology and types of brachytherapy.
