RAAS Medications Quiz

Which of the following medications inhibits ACE and leads to increased bradykinin levels?

Which type of medication acts as a competitive antagonist at AT1R without inhibiting AG2 production or bradykinin breakdown?

Which type of medication competitively inhibits renin enzyme and leads to no AG1 production?

Which of the following medications acts as a competitive antagonist at AT1R without inhibiting AG2 production or bradykinin breakdown?

Which medication inhibits ACE and leads to increased bradykinin levels?

Which type of medication competitively inhibits renin enzyme and leads to no AG1 production?

ACE Inhibitors

Medications that inhibit Angiotensin-Converting Enzyme (ACE) lead to increased levels of bradykinin, a peptide that promotes vasodilation.
Common ACE inhibitors include lisinopril, ramipril, and enalapril.

Angiotensin II Receptor Blockers (ARBs)

Competitive antagonists at Angiotensin II Type 1 Receptors (AT1R) do not inhibit the production of Angiotensin II (AG2) or the breakdown of bradykinin.
Examples of ARBs include losartan and valsartan, which lower blood pressure but maintain bradykinin levels.

Renin Inhibitors

Medications that act as competitive inhibitors of the renin enzyme prevent the formation of Angiotensin I (AG1).
Aliskiren is a primary renin inhibitor that directly affects the renin-angiotensin system.

Summary of ANSI and Their Actions

ACE inhibitors increase bradykinin levels while reducing Angiotensin II.
ARBs block the action of Angiotensin II at its receptor without decreasing bradykinin.
Renin inhibitors halt the production of Angiotensin I without affecting bradykinin or Angiotensin II levels.

Test your knowledge of medications acting on the Renin-Angiotensin-Aldosterone System (RAAS) with this quiz. Identify ACE inhibitors and Angiotensin 2 receptor antagonists (Sartans) and understand their mechanisms of action.