small molecule drug discovery primer section 3

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Questions and Answers

What is a drug candidate?

  • A molecule that has been validated as a potential drug
  • A molecule that could potentially be developed into a new medicine (correct)
  • A molecule that has undergone lead candidate selection
  • A molecule that has been optimized for therapeutic use

What is High Throughput Screening (HTS)?

  • A method for screening drug candidates using automation (correct)
  • A method for target identification and validation
  • A method for lead candidate selection
  • A method for lead candidate optimization

What is the purpose of lead candidate selection?

  • To validate the target for drug discovery
  • To identify drug candidates with desired properties (correct)
  • To minimize the side effects of drug candidates
  • To optimize the beneficial effects of drug candidates

What is the next step after drug candidate identification in the drug discovery process?

<p>Lead candidate selection (C)</p> Signup and view all the answers

Which type of assay involves screening small, low molecular weight fragments for the desired biological activity?

<p>Fragment-based screening (C)</p> Signup and view all the answers

Which characteristic should a lead candidate exhibit to exert the desired biological activity at the target?

<p>Potency (C)</p> Signup and view all the answers

What does oral bioavailability refer to?

<p>The ability of a drug to be effectively delivered to the target tissue when taken orally (B)</p> Signup and view all the answers

What is the last step of drug discovery called?

<p>Lead candidate optimization (C)</p> Signup and view all the answers

What is the goal of lead candidate optimization?

<p>To maintain the lead candidate's desired biological activity (A)</p> Signup and view all the answers

What techniques are used to identify a Hit?

<p>High Throughput Screening and CADD (B)</p> Signup and view all the answers

What properties are improved during lead candidate optimization?

<p>Solubility, permeability, metabolic stability, and toxicity (B)</p> Signup and view all the answers

What are the iterative cycles involved in lead candidate optimization?

<p>Design, synthesis, and biological testing (A)</p> Signup and view all the answers

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