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small molecule drug discovery primer section 3

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small molecule drug discovery primer section 3

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Questions and Answers

What is a drug candidate?

A molecule that has been validated as a potential drug

A molecule that could potentially be developed into a new medicine (correct)

A molecule that has undergone lead candidate selection

A molecule that has been optimized for therapeutic use

What is High Throughput Screening (HTS)?

A method for screening drug candidates using automation (correct)

A method for target identification and validation

A method for lead candidate selection

A method for lead candidate optimization

What is the purpose of lead candidate selection?

To validate the target for drug discovery

To identify drug candidates with desired properties (correct)

To minimize the side effects of drug candidates

To optimize the beneficial effects of drug candidates

What is the next step after drug candidate identification in the drug discovery process?

Lead candidate selection (C) Signup and view all the answers

Which type of assay involves screening small, low molecular weight fragments for the desired biological activity?

Fragment-based screening (C) Signup and view all the answers

Which characteristic should a lead candidate exhibit to exert the desired biological activity at the target?

Potency (C) Signup and view all the answers

What does oral bioavailability refer to?

The ability of a drug to be effectively delivered to the target tissue when taken orally (B) Signup and view all the answers

What is the last step of drug discovery called?

Lead candidate optimization (C) Signup and view all the answers

What is the goal of lead candidate optimization?

To maintain the lead candidate's desired biological activity (A) Signup and view all the answers

What techniques are used to identify a Hit?

High Throughput Screening and CADD (B) Signup and view all the answers

What properties are improved during lead candidate optimization?

Solubility, permeability, metabolic stability, and toxicity (B) Signup and view all the answers

What are the iterative cycles involved in lead candidate optimization?

Design, synthesis, and biological testing (A) Signup and view all the answers