small molecule therapy

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Questions and Answers

what hallmark of cancer do PARP inhibitors target?

genome instability and mutation

name the 6 small molecules for targetted cancer therapy

kinase inhibitors (tyrosine and serine), epigenetic inhibitors (epidrugs), proteosome inhibitors, BCL-2 inhibitors and PARP inhibitors

what are the two groups of tyrosine kinase inhibitors?

receptor tyrosine kinase inhibitors and non-receptor tyrosine kinases

what pathways do serine kinase inhibitors target?

growth and apoptosis pathways and CDK inhibitors control cell cycle pathways Signup and view all the answers

what do proteasome inhibitors do?

block the proteosome pathway responsible for protein degradation and the production of growth-promoting proteins Signup and view all the answers

what do BCL-2 inhibitors do?

promote apoptosis Signup and view all the answers

give an example of a BCL-2 inhibitor

BH3 mimetics Signup and view all the answers

give some examples of receptor tyrosine kinase inhibitors

EGFR, VEGFR, Getfitinib Signup and view all the answers

how do tyrosine kinase inhibitors work?

by blobking the activity of tyrosine kinase enzymes which a responsible for pathways involved in cell growth proliferation and survival Signup and view all the answers

explain the role of tyrosine kinases in cancer

in cancer tyrosine kinases are over activated leading to uncontrolled cell growth and tumour progression Signup and view all the answers