10 Questions
what hallmark of cancer do PARP inhibitors target?
genome instability and mutation
name the 6 small molecules for targetted cancer therapy
kinase inhibitors (tyrosine and serine), epigenetic inhibitors (epidrugs), proteosome inhibitors, BCL-2 inhibitors and PARP inhibitors
what are the two groups of tyrosine kinase inhibitors?
receptor tyrosine kinase inhibitors and non-receptor tyrosine kinases
what pathways do serine kinase inhibitors target?
growth and apoptosis pathways and CDK inhibitors control cell cycle pathways
what do proteasome inhibitors do?
block the proteosome pathway responsible for protein degradation and the production of growth-promoting proteins
what do BCL-2 inhibitors do?
promote apoptosis
give an example of a BCL-2 inhibitor
BH3 mimetics
give some examples of receptor tyrosine kinase inhibitors
EGFR, VEGFR, Getfitinib
how do tyrosine kinase inhibitors work?
by blobking the activity of tyrosine kinase enzymes which a responsible for pathways involved in cell growth proliferation and survival
explain the role of tyrosine kinases in cancer
in cancer tyrosine kinases are over activated leading to uncontrolled cell growth and tumour progression
Learn about PARP inhibitors and how they target a specific hallmark of cancer. Test your knowledge on the role of PARP inhibitors in cancer treatment.
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