small molecule therapy

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Questions and Answers

what hallmark of cancer do PARP inhibitors target?

genome instability and mutation

name the 6 small molecules for targetted cancer therapy

kinase inhibitors (tyrosine and serine), epigenetic inhibitors (epidrugs), proteosome inhibitors, BCL-2 inhibitors and PARP inhibitors

what are the two groups of tyrosine kinase inhibitors?

receptor tyrosine kinase inhibitors and non-receptor tyrosine kinases

what pathways do serine kinase inhibitors target?

<p>growth and apoptosis pathways and CDK inhibitors control cell cycle pathways</p> Signup and view all the answers

what do proteasome inhibitors do?

<p>block the proteosome pathway responsible for protein degradation and the production of growth-promoting proteins</p> Signup and view all the answers

what do BCL-2 inhibitors do?

<p>promote apoptosis</p> Signup and view all the answers

give an example of a BCL-2 inhibitor

<p>BH3 mimetics</p> Signup and view all the answers

give some examples of receptor tyrosine kinase inhibitors

<p>EGFR, VEGFR, Getfitinib</p> Signup and view all the answers

how do tyrosine kinase inhibitors work?

<p>by blobking the activity of tyrosine kinase enzymes which a responsible for pathways involved in cell growth proliferation and survival</p> Signup and view all the answers

explain the role of tyrosine kinases in cancer

<p>in cancer tyrosine kinases are over activated leading to uncontrolled cell growth and tumour progression</p> Signup and view all the answers

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