Quinidine Adverse Effects and Drug Interactions Quiz

Inhibits the conversion of angiotensinogen into angiotensin I, suppressing the entire RAAS.

Captopril is used for high blood pressure, heart failure, and nephropathy.

Angioedema can be fatal and is linked to increased capillary permeability.

<p>Category D drugs, with a black box warning, can cause rebound hypertension if abruptly discontinued.</p> Signup and view all the answers

<p>Eplerenone is used for hypertension and heart failure.</p> Signup and view all the answers

<p>Drugs that increase potassium levels or lithium can interact with ACE inhibitors.</p> Signup and view all the answers

<p>Losartan is used for high blood pressure, stroke prevention, and diabetic nephropathy.</p> Signup and view all the answers

<p>Lupus-like syndrome</p> Signup and view all the answers

<p>Blood pressure, heart failure, and hypertensive crisis</p> Signup and view all the answers

<p>Promote dilation of veins to decrease oxygen demand</p> Signup and view all the answers

<p>Headache</p> Signup and view all the answers

<p>All hypotensive drugs can interact with nitroglycerin, leading to severe hypotension</p> Signup and view all the answers

<p>Calcium channel blockers prevent calcium from entering cells, especially in the heart and blood vessels, which decreases heart rate and myocardial contraction.</p> Signup and view all the answers

<p>The main therapeutic uses of CCBs include treatment of hypertension, angina pectoris, and dysrhythmias. They may also be used for migraine prevention.</p> Signup and view all the answers

<p>Common adverse effects of CCBs include headaches, drowsiness, flushing, fatigue, edema, and postural hypotension with reflex tachycardia.</p> Signup and view all the answers

<p>The different CCB classes have varying effects on the cardiovascular system - 1st/2nd generation CCBs (e.g. nifedipine) primarily affect peripheral vasculature, while 3rd/4th generation CCBs (e.g. verapamil, diltiazem) have more direct effects on the heart.</p> Signup and view all the answers

<p>Digoxin, a cardiac glycoside, is used less frequently now because it has not been shown to prolong life. It is considered a second-line therapy for conditions like heart failure.</p> Signup and view all the answers

<p>Organic nitrates are vasodilators that work by increasing cardiac output through their inotropic and chronotropic effects, as well as reducing the workload on the heart.</p> Signup and view all the answers

<p>Hydralazine is a vasodilator used in the treatment of severe hypertension, but it has potential for serious side effects, so its use is limited.</p> Signup and view all the answers

<p>ACE inhibitors reduce levels of angiotensin II, dilating blood vessels. ARBs block access to angiotensin II receptors in blood vessels and tissues, increasing bradykinins which also dilate vessels.</p> Signup and view all the answers

<p>Hypertension, heart failure, myocardial infarction, nephropathy (diabetic and preventing end-stage renal disease), preventing cardiovascular events like MI and stroke.</p> Signup and view all the answers

<p>Dry, irritating, nonproductive cough due to increased kinase II levels.</p> Signup and view all the answers

<p>ACE inhibitors and ARBs are safe for asthma patients, while beta blockers can exacerbate asthma symptoms.</p> Signup and view all the answers

<p>First dose hypotension, especially if the patient is also on a diuretic.</p> Signup and view all the answers

<p>Lisinopril. ACE inhibitor drug names end in the syllable '-pril'.</p> Signup and view all the answers

<p>Losartan. ARB drug names end in the syllable '-artan'.</p> Signup and view all the answers

<p>Most are oral, can be given with food, dosed once or twice daily. They are excreted by the kidneys.</p> Signup and view all the answers

<p>Dizziness, muscle cramps or weakness, heartburn, diarrhea, sensitivity to touch.</p> Signup and view all the answers