20 Questions
What is the primary purpose of Ethambutol in tuberculosis treatment?
Prevent the emergence of Rifampin resistance
Why does the Continuation Phase of tuberculosis treatment last 4 or 7 months?
To eliminate remaining TB bacilli
What is the standard of care for initiating treatment of tuberculosis?
Four-drug regimen
Which drug is primarily responsible for inhibiting the biosynthesis of mycolic acid in tuberculosis treatment?
Isoniazid
What is the main route of elimination for Rifampin in the body?
Feces
What is the purpose of the intensive phase of tuberculosis (TB) treatment?
To prevent the emergence of drug resistance
Why is monotherapy usually not recommended for anti-mycobacteria drug treatment?
Due to the risk of drug resistance
Which drugs should be included during the intensive phase of TB treatment?
Isoniazid, Rifampin, Pyrazinamide, and Ethambutol
Why are anti-mycobacteria drugs considered diverse compounds?
Due to their varied chemical structures
What is the activity of Isoniazid and Rifampin during the intensive phase of TB treatment?
They kill active growing TB bacilli
Pyrazinamide is included in the intensive phase of tuberculosis treatment.
True
Rifampin has potent sterilizing activity against tuberculosis bacilli.
True
Isoniazid is primarily eliminated through renal excretion.
True
Ethambutol is used as monotherapy for latent tuberculosis.
False
Directly observed therapy (DOT) can be conducted electronically to improve adherence to tuberculosis treatment.
True
Why is nonadherence considered a major problem in controlling tuberculosis?
It can lead to drug resistance
Which drug is primarily responsible for inhibiting the biosynthesis of mycolic acid in tuberculosis treatment?
Isoniazid
What is the main route of elimination for Rifampin in the body?
Biliary excretion
Why is Pyrazinamide not included in the Continuation Phase of tuberculosis treatment for some patients?
It has potent sterilizing activity against tuberculosis bacilli
What is the primary purpose of Ethambutol in tuberculosis treatment?
To prevent emergence of Rifampin resistance
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