Autoimmunity

<p>Genetic predisposition, abnormal antigen display, inflammation, or cross-reactivity due to infection (C)</p> Signup and view all the answers

<p>When RBC lose CD47 during aging, allowing phagocytosis by macrophages (B)</p> Signup and view all the answers

<p>Yes, hidden antigens released after tissue damage can lead to autoantibody production (D)</p> Signup and view all the answers

<p>Regulates tolerance by controlling the expression of self-antigens in the thymus; defects lead to autoimmunity (B)</p> Signup and view all the answers

<p>An autoantibody against the Fc region of IgG (A)</p> Signup and view all the answers

<p>Systemic Lupus Erythematosus (SLE) (C)</p> Signup and view all the answers

<p>A shared epitope between a pathogen and a host that induces autoimmunity (D)</p> Signup and view all the answers

<p>When pathogens carry antigens that resemble host proteins, triggering an immune response against both (A)</p> Signup and view all the answers

<p>Molecular mimicry is caused by cross-reactivity between pathogen and host antigens, while bystander activation is the stimulation of non-specific lymphocytes by cytokines during infection (B)</p> Signup and view all the answers

<p>Hypersensitivity types I, II, III and IV (C)</p> Signup and view all the answers

<p>By production of autoantibodies against thyroglobulin or thyroid peroxidase, blocking hormone production and infiltrating thyroid tissue with lymphocytes (C)</p> Signup and view all the answers

<p>T cell mediated destruction of B cells through type IV hypersensitivity (A)</p> Signup and view all the answers

<p>ADCC</p> Signup and view all the answers

<p>Myelin P2 protein (B)</p> Signup and view all the answers

<p>Autoantibodies against trichohyalin, a protein in hair follicles, leading to hair loss (D)</p> Signup and view all the answers

<p>Autoantibodies against acetylcholine receptors block nerve impulse transmission and destroy receptors via complement fixation (B)</p> Signup and view all the answers

<p>Pemphigus foliaceus, pemphigus vulgaris, alopecia areata</p> Signup and view all the answers

<p>Bulbous pemphigoid (C)</p> Signup and view all the answers

<p>An autoimmune disease targeting type XVII collagen in the skin basal membrane, leading to subepidermal blisters (A)</p> Signup and view all the answers

<p>The epidermis, specifically targeting desmoglein 3 (C)</p> Signup and view all the answers

Immune response against the body's own tissues, either antibody-mediated or cell-mediated.

Loss of tolerance to self-antigens, can be systemic or organ-specific, and are chronic and progressive.

Immune response targeting a specific organ due to abnormal immune response against its own components.

Genetic predisposition, abnormal antigen display, inflammation, or cross-reactivity with infections.

Autoimmunity that is a normal part of aging.

Hidden antigens exposed after tissue damage can trigger autoantibody production.

Regulates tolerance by controlling self-antigen expression in the thymus; defects can lead to autoimmunity.

Autoantibody attacking the Fc region of IgG.

Shared epitopes between pathogens and host proteins causing autoimmunity.

Pathogens resemble proteins, triggering immune attack.

Mimicry is cross-reactivity between pathogen and host antigens, bystander is non-specific lymphocyte stimulation.

Hypersensitivity types I, II, III, and IV are the mechanisms behind autoimmune disorder pathologies.

Production of autoantibodies against thyroid components (e.g., thyroglobulin, peroxidase) causing thyroid damage.

T-cell mediated destruction of B-cells, a type IV hypersensitivity response

Target is myelin P2 protein causing nerve issues.

Autoantibodies against trichohyalin, a protein in hair follicles, leading to hair loss.

Autoantibodies against acetylcholine receptors block nerve impulses.

Located in the epidermis, affecting desmoglein 3.

Autoimmune disease targeting collagen type XVII, causing skin blisters.