Pyruvate Kinase Deficiency Quiz

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Questions and Answers

Which enzyme deficiency is the second most common cause of nonspherocytic hemolytic anemia?

  • Glucose-6-phosphate dehydrogenase deficiency
  • Hexokinase deficiency
  • Pyruvate kinase deficiency (correct)
  • Fructose-1,6-bisphosphatase deficiency

What inhibits the liver enzyme pyruvate kinase?

  • F-1,6-BP
  • Protein kinase A
  • ATP and acetyl-CoA (correct)
  • Increased carbohydrate ingestion

What activates the liver enzyme pyruvate kinase?

  • F-1,6-BP (correct)
  • Protein kinase A
  • ATP and acetyl-CoA
  • Increased carbohydrate ingestion

What induces the synthesis of pyruvate kinase in the liver?

<p>Increased carbohydrate ingestion (A)</p> Signup and view all the answers

What inhibits liver pyruvate kinase and puts it under hormonal control?

<p>Protein kinase A (A)</p> Signup and view all the answers

What is the role of protein kinase A in the regulation of liver pyruvate kinase?

<p>Inhibits it (D)</p> Signup and view all the answers

What is the feed-forward regulation that activates liver pyruvate kinase?

<p>F-1,6-BP (C)</p> Signup and view all the answers

What is the most common cause of enzyme deficiency-related nonspherocytic hemolytic anemia?

<p>Glucose-6-phosphate dehydrogenase deficiency (C)</p> Signup and view all the answers

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