8 Questions
Which enzyme deficiency is the second most common cause of nonspherocytic hemolytic anemia?
Pyruvate kinase deficiency
What inhibits the liver enzyme pyruvate kinase?
ATP and acetyl-CoA
What activates the liver enzyme pyruvate kinase?
F-1,6-BP
What induces the synthesis of pyruvate kinase in the liver?
Increased carbohydrate ingestion
What inhibits liver pyruvate kinase and puts it under hormonal control?
Protein kinase A
What is the role of protein kinase A in the regulation of liver pyruvate kinase?
Inhibits it
What is the feed-forward regulation that activates liver pyruvate kinase?
F-1,6-BP
What is the most common cause of enzyme deficiency-related nonspherocytic hemolytic anemia?
Glucose-6-phosphate dehydrogenase deficiency
Test your knowledge of Pyruvate Kinase Deficiency with our quiz! Learn about the enzyme's unusual feed-forward regulation, how it's inhibited and activated, and how increased carbohydrate ingestion affects its synthesis in the liver. Challenge yourself with questions about the second most common cause of enzyme deficiency-related nonspherocytic hemolytic anemia.
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