Pyruvate Kinase Deficiency Quiz
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Questions and Answers

Which enzyme deficiency is the second most common cause of nonspherocytic hemolytic anemia?

  • Glucose-6-phosphate dehydrogenase deficiency
  • Hexokinase deficiency
  • Pyruvate kinase deficiency (correct)
  • Fructose-1,6-bisphosphatase deficiency
  • What inhibits the liver enzyme pyruvate kinase?

  • F-1,6-BP
  • Protein kinase A
  • ATP and acetyl-CoA (correct)
  • Increased carbohydrate ingestion
  • What activates the liver enzyme pyruvate kinase?

  • F-1,6-BP (correct)
  • Protein kinase A
  • ATP and acetyl-CoA
  • Increased carbohydrate ingestion
  • What induces the synthesis of pyruvate kinase in the liver?

    <p>Increased carbohydrate ingestion</p> Signup and view all the answers

    What inhibits liver pyruvate kinase and puts it under hormonal control?

    <p>Protein kinase A</p> Signup and view all the answers

    What is the role of protein kinase A in the regulation of liver pyruvate kinase?

    <p>Inhibits it</p> Signup and view all the answers

    What is the feed-forward regulation that activates liver pyruvate kinase?

    <p>F-1,6-BP</p> Signup and view all the answers

    What is the most common cause of enzyme deficiency-related nonspherocytic hemolytic anemia?

    <p>Glucose-6-phosphate dehydrogenase deficiency</p> Signup and view all the answers

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