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Questions and Answers
Which factor is the major determinant of the overall rate of de novo purine nucleotide biosynthesis?
Which enzyme is sensitive to feedback inhibition by purine nucleotides?
Which compound can block purine synthesis?
Which enzyme is regulated by AMP feedback and inhibits the formation of adenylosuccinate?
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Study Notes
De Novo Purine Nucleotide Biosynthesis
- The major determinant of the overall rate of de novo purine nucleotide biosynthesis is the availability of phosphoribosyl pyrophosphate (PRPP).
Regulation of Purine Synthesis
- The enzyme amidophosphoribosyl transferase is sensitive to feedback inhibition by purine nucleotides.
- The compound azaserine can block purine synthesis.
Adenylosuccinate Formation
- The enzyme adenylosuccinate synthase is regulated by AMP feedback, and inhibits the formation of adenylosuccinate.
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Description
Test your knowledge on the steps involved in the biosynthesis of pyrimidine nucleotides. Explore the formation of carbamoyl phosphate and the crucial role of cytosolic carbamoyl phosphate synthetase in this process.
