Pyrimidine Nucleotide Biosynthesis Quiz
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Questions and Answers

Which factor is the major determinant of the overall rate of de novo purine nucleotide biosynthesis?

  • Concentration of PRPP (correct)
  • Formation of tetrahydrofolate compounds
  • PRPP amidotransferase
  • Concentration of purine nucleotides
  • Which enzyme is sensitive to feedback inhibition by purine nucleotides?

  • Adenylosuccinate synthetase
  • Dihydroorotase
  • PRPP amidotransferase (correct)
  • IMP dehydrogenase
  • Which compound can block purine synthesis?

  • Tetrahydrofolate compounds
  • PRPP
  • Methotrexate (correct)
  • Purine nucleotides
  • Which enzyme is regulated by AMP feedback and inhibits the formation of adenylosuccinate?

    <p>Adenylosuccinate synthetase</p> Signup and view all the answers

    Study Notes

    De Novo Purine Nucleotide Biosynthesis

    • The major determinant of the overall rate of de novo purine nucleotide biosynthesis is the availability of phosphoribosyl pyrophosphate (PRPP).

    Regulation of Purine Synthesis

    • The enzyme amidophosphoribosyl transferase is sensitive to feedback inhibition by purine nucleotides.
    • The compound azaserine can block purine synthesis.

    Adenylosuccinate Formation

    • The enzyme adenylosuccinate synthase is regulated by AMP feedback, and inhibits the formation of adenylosuccinate.

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    Description

    Test your knowledge on the steps involved in the biosynthesis of pyrimidine nucleotides. Explore the formation of carbamoyl phosphate and the crucial role of cytosolic carbamoyl phosphate synthetase in this process.

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