Podcast
Questions and Answers
Which factor is the major determinant of the overall rate of de novo purine nucleotide biosynthesis?
Which factor is the major determinant of the overall rate of de novo purine nucleotide biosynthesis?
- Concentration of PRPP (correct)
- Formation of tetrahydrofolate compounds
- PRPP amidotransferase
- Concentration of purine nucleotides
Which enzyme is sensitive to feedback inhibition by purine nucleotides?
Which enzyme is sensitive to feedback inhibition by purine nucleotides?
- Adenylosuccinate synthetase
- Dihydroorotase
- PRPP amidotransferase (correct)
- IMP dehydrogenase
Which compound can block purine synthesis?
Which compound can block purine synthesis?
- Tetrahydrofolate compounds
- PRPP
- Methotrexate (correct)
- Purine nucleotides
Which enzyme is regulated by AMP feedback and inhibits the formation of adenylosuccinate?
Which enzyme is regulated by AMP feedback and inhibits the formation of adenylosuccinate?
Flashcards
Rate-limiting factor in purine synthesis
Rate-limiting factor in purine synthesis
The concentration of PRPP (5-phosphoribosyl-1-pyrophosphate).
Purine synthesis regulatory enzyme
Purine synthesis regulatory enzyme
PRPP amidotransferase is subject to feedback inhibition by purine nucleotides, regulating purine synthesis.
Purine synthesis inhibitor
Purine synthesis inhibitor
Methotrexate inhibits purine synthesis by interfering with folate metabolism, affecting nucleotide production.
Enzyme regulated by AMP feedback
Enzyme regulated by AMP feedback
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Study Notes
De Novo Purine Nucleotide Biosynthesis
- The major determinant of the overall rate of de novo purine nucleotide biosynthesis is the availability of phosphoribosyl pyrophosphate (PRPP).
Regulation of Purine Synthesis
- The enzyme amidophosphoribosyl transferase is sensitive to feedback inhibition by purine nucleotides.
- The compound azaserine can block purine synthesis.
Adenylosuccinate Formation
- The enzyme adenylosuccinate synthase is regulated by AMP feedback, and inhibits the formation of adenylosuccinate.
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Description
Test your knowledge on the steps involved in the biosynthesis of pyrimidine nucleotides. Explore the formation of carbamoyl phosphate and the crucial role of cytosolic carbamoyl phosphate synthetase in this process.
