Podcast
Questions and Answers
Which enzyme catalyses the final step of the purine biosynthesis pathway?
Which enzyme catalyses the final step of the purine biosynthesis pathway?
How is GMP converted to GTP in the purine biosynthesis pathway?
How is GMP converted to GTP in the purine biosynthesis pathway?
What is the role of nucleoside-diphosphate kinase in purine biosynthesis?
What is the role of nucleoside-diphosphate kinase in purine biosynthesis?
What enzyme catalyzes the conversion of AMP to adenosine diphosphate in purine biosynthesis?
What enzyme catalyzes the conversion of AMP to adenosine diphosphate in purine biosynthesis?
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How is GMP converted to GTP in the purine biosynthesis pathway?
How is GMP converted to GTP in the purine biosynthesis pathway?
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What is the role of nucleotide-diphosphate kinase in purine biosynthesis?
What is the role of nucleotide-diphosphate kinase in purine biosynthesis?
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Study Notes
Purine Biosynthesis Pathway Enzymes and Processes
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The final step of the purine biosynthesis pathway is catalyzed by inosine monophosphate dehydrogenase (IMPDH), which converts inosine monophosphate (IMP) to xanthosine monophosphate (XMP).
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Guanosine monophosphate (GMP) is converted to guanosine triphosphate (GTP) through a two-step phosphorylation process. First, GMP is phosphorylated to guanosine diphosphate (GDP) by nucleotide monophosphate kinase (NMPK), followed by the conversion of GDP to GTP by nucleotide diphosphate kinase (NDPK).
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Nucleoside-diphosphate kinase (NDPK) plays a crucial role in purine biosynthesis by facilitating the transfer of phosphate groups among nucleoside diphosphates (NDPs). It helps in the conversion of ADP to ATP and GDP to GTP, thus balancing nucleotide pools.
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The conversion of adenosine monophosphate (AMP) to adenosine diphosphate (ADP) is catalyzed by the enzyme adenylate kinase, which facilitates the reversible phosphorylation reaction involving ATP and AMP.
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Description
Test your knowledge of purine biosynthesis and nucleoside-diphosphate kinase (NDK) with this quiz. Challenge yourself with questions about the salvage pathway, enzyme reactions, and the conversion of AMP and GMP to their respective triphosphate forms.
