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Questions and Answers
What is the primary source of uric acid in the body?
What is the primary source of uric acid in the body?
- Breakdown of proteins
- Metabolism of purines (correct)
- Digestion of carbohydrates
- Metabolism of pyrimidines
Which of the following statements about uric acid is true?
Which of the following statements about uric acid is true?
- It has no role in the turnover of nucleoproteins.
- It is produced from the breakdown of lipids.
- It is present in RNA and DNA. (correct)
- It is excreted solely by the kidneys.
How much uric acid does the body typically produce each day?
How much uric acid does the body typically produce each day?
- 1200 mg
- 2400 mg
- 600 mg (correct)
- 300 mg
In what form is uric acid predominantly found in plasma?
In what form is uric acid predominantly found in plasma?
Where in the body is a significant amount of uric acid turnover occurring?
Where in the body is a significant amount of uric acid turnover occurring?
Flashcards
Uric acid production
Uric acid production
Uric acid is formed from the breakdown of purines, a component of RNA and DNA.
Uric acid location
Uric acid location
Uric acid is found in the body's fluids, like plasma, as a monosodium salt.
Daily Uric Acid Turnover
Daily Uric Acid Turnover
About 600 mg of uric acid is produced and lost daily, maintaining a balanced pool in the body.
Uric acid pool size
Uric acid pool size
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Purine Metabolism Source 1
Purine Metabolism Source 1
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Study Notes
Uric Acid Metabolism
- Uric acid is the final product of purine metabolism in the liver.
- Purines include adenine and guanine, components of RNA and DNA.
- Uric acid production also results from the high turnover of nucleoproteins in bone marrow and the gastrointestinal tract (GIT). These nucleoproteins contain purines and pyrimidines.
- Uric acid exists as monosodium salt in plasma.
- The total body pool of uric acid is approximately 1200 mg.
- About half of the uric acid pool (600 mg) is turned over daily.
- Approximately 600 mg of uric acid is produced daily.
- An equivalent amount of 600 mg is lost daily.
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