Psychotropic Medications and CNS Review

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Questions and Answers

Which system is responsible for relaying sensory information to the brain?

  • Motor Neurons
  • Sensory Neurons (correct)
  • Central Nervous System
  • Somatic Nervous System

Which of these is a component of the central nervous system?

  • Motor Neurons
  • Somatic Nervous System
  • Sensory Neurons
  • Spinal Cord (correct)

What is the primary function of the somatic nervous system?

  • Regulating involuntary muscle movements
  • Relaying sensory signals to the brain
  • Transmitting signals from the brain to sensory organs
  • Controlling voluntary muscle movements (correct)

Where can healthcare professionals find detailed information about drug contraindications?

<p>DailyMed (A)</p> Signup and view all the answers

Which type of resource should nurses consult to find the most current information about psychotropic medications?

<p>Evidence-based resources (D)</p> Signup and view all the answers

What is the primary focus of psychotropic medications?

<p>The mind, emotions, and behavior (D)</p> Signup and view all the answers

What kind of information do MedlinePlus resources provide?

<p>Lay language medication information for clients (C)</p> Signup and view all the answers

What is a key factor influencing the need for nurses to consult reliable medication resources?

<p>The constant updates to medication information (A)</p> Signup and view all the answers

The 'fight-or-flight' response is primarily associated with the activity of which nervous system?

<p>Sympathetic Nervous System (C)</p> Signup and view all the answers

Which of the following is a direct effect of parasympathetic nervous system stimulation on the heart?

<p>Decreased heart rate (B)</p> Signup and view all the answers

Stimulation of which receptor type would cause increased heart rate and blood pressure?

<p>Beta-1 receptors (D)</p> Signup and view all the answers

An adrenergic antagonist, such as propranolol, would likely have which effect on a patient experiencing a panic attack?

<p>Decreased heart rate (C)</p> Signup and view all the answers

Which of the following is an example of a cholinergic drug that stimulates the parasympathetic nervous system?

<p>Bethanechol (D)</p> Signup and view all the answers

A patient taking an anticholinergic medication is likely to experience which of the following?

<p>Blurred vision (D)</p> Signup and view all the answers

Which neurotransmitter is primarily associated with the stimulation of PNS receptors?

<p>Acetylcholine (D)</p> Signup and view all the answers

Which of the following is an example of an exogenous substance that stimulates opioid receptors?

<p>Heroin (A)</p> Signup and view all the answers

What is the primary effect of stimulant medications used for ADHD?

<p>Block the reuptake of norepinephrine and dopamine (D)</p> Signup and view all the answers

Why are stimulant medications classified as Schedule II controlled substances?

<p>They have a high potential for misuse and dependence (B)</p> Signup and view all the answers

Which medication is NOT used for treating alcohol use disorder?

<p>Methadone (C)</p> Signup and view all the answers

Which neurotransmitter is NOT classified as a catecholamine?

<p>Serotonin (B)</p> Signup and view all the answers

What does agranulocytosis refer to in the context of medication effects?

<p>Extremely low white blood cell count (B)</p> Signup and view all the answers

What action do adrenergic antagonists perform?

<p>Block SNS receptors (D)</p> Signup and view all the answers

What is the role of buprenorphine in substance withdrawal?

<p>Reduces cravings and withdrawal symptoms (C)</p> Signup and view all the answers

Which of the following is a characteristic of cholinergic substances?

<p>Stimulate nicotinic and muscarinic receptors (B)</p> Signup and view all the answers

Which neurotransmitter is associated with excitatory signals and elevated levels in psychosis?

<p>Glutamate (B)</p> Signup and view all the answers

What effect does bupropion have on dopamine levels in the brain?

<p>It inhibits dopamine reuptake (B)</p> Signup and view all the answers

Which situation is most likely to be linked with low levels of GABA?

<p>Increase in seizure frequency (C)</p> Signup and view all the answers

Which drug is known to mimic GABA's effects and is used for generalized anxiety disorder?

<p>Pregabalin (B)</p> Signup and view all the answers

What is the primary use of antidepressants?

<p>Treat depression and related conditions (C)</p> Signup and view all the answers

Which neurotransmitter is primarily linked to the regulation of mood and sleeping patterns?

<p>Serotonin (D)</p> Signup and view all the answers

What role do norepinephrine and epinephrine play in the body's response system?

<p>Stimulate alpha- and beta-receptors (B)</p> Signup and view all the answers

Which neurotransmitter is NOT typically associated with inhibitory functions?

<p>Glutamate (A)</p> Signup and view all the answers

What is the primary mechanism of action for benzodiazepines in treating anxiety?

<p>Stimulate the effects of GABA (C)</p> Signup and view all the answers

Which of the following benzodiazepines is commonly prescribed for short-term anxiety management?

<p>Lorazepam (D)</p> Signup and view all the answers

Why are benzodiazepines classified as Schedule IV controlled substances?

<p>They have a high potential for misuse and dependence. (D)</p> Signup and view all the answers

What is a common use for beta-blockers in the context of anxiety management?

<p>To alleviate physical symptoms of anxiety (A)</p> Signup and view all the answers

At what serum concentration does lithium toxicity typically occur?

<p>0.8 to 1.2 mEq/L (A)</p> Signup and view all the answers

Which mental disorder is NOT typically treated with antipsychotic medications?

<p>Generalized Anxiety Disorder (A)</p> Signup and view all the answers

Which medication class is most commonly prescribed for the treatment of panic attacks?

<p>Antidepressants (B)</p> Signup and view all the answers

In addition to treating psychosis, antipsychotic medications may be used for all of the following EXCEPT:

<p>Generalized anxiety disorder (B)</p> Signup and view all the answers

What is the primary action of SSRIs in treating depression?

<p>Prevent the reuptake of serotonin at the synapse. (C)</p> Signup and view all the answers

Which of the following is a side effect commonly associated with tricyclic antidepressants (TCAs)?

<p>Urinary retention (A)</p> Signup and view all the answers

Why are first-generation antidepressants like TCAs and MAOIs less commonly prescribed than newer antidepressants?

<p>They tend to have more side effects. (C)</p> Signup and view all the answers

What class of antidepressants includes bupropion?

<p>Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs) (A)</p> Signup and view all the answers

Which of the following conditions is NOT typically treated with SSRIs?

<p>Seasonal Affective Disorder (A)</p> Signup and view all the answers

What is a potential action of Serotonin Antagonist and Reuptake Inhibitors?

<p>Reduce neurotransmitters associated with arousal effects (C)</p> Signup and view all the answers

Which of the following statements about SNRIs is accurate?

<p>They inhibit both serotonin and norepinephrine reuptake. (A)</p> Signup and view all the answers

What is a common use for Tricyclic Antidepressants (TCAs) aside from treating depression?

<p>Treating neuropathic pain (A)</p> Signup and view all the answers

Flashcards

Central Nervous System (CNS)

The brain and spinal cord, responsible for processing information and controlling bodily functions.

Peripheral Nervous System (PNS)

All parts of the nervous system outside the CNS, responsible for transmitting information between the CNS and the body.

Sensory Neurons

Specialized nerve cells that transmit sensory information from the environment to the brain.

Motor Neurons

Nerve cells that transmit signals from the brain to muscles and organs, causing them to move or function.

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Somatic Nervous System

A branch of motor neurons that controls voluntary movements, such as walking or writing.

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Psychotropic Medications

Medications that affect the mind, emotions, and behavior.

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DailyMed

A reliable online source for up-to-date information on prescription and over-the-counter medications, provided by the National Library of Medicine.

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MedlinePlus

A resource for patients and their families to get easy-to-understand medication information.

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Autonomic Nervous System (ANS)

The part of the nervous system that controls involuntary bodily functions like heart rate, digestion, and breathing.

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Sympathetic Nervous System (SNS)

The division of the ANS that prepares the body for 'fight-or-flight' responses, increasing heart rate, blood pressure, and breathing.

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Parasympathetic Nervous System (PNS)

The division of the ANS that promotes 'rest-and-digest' activities, slowing heart rate, lowering blood pressure, and promoting digestion.

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Homeostatic Regulation

A state of balance in the body's internal environment, maintained through the actions of the SNS and PNS.

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Epinephrine and Norepinephrine

Chemicals released by the SNS that bind to receptors on cells, causing various effects.

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Adrenergic Agonists

Drugs that mimic the effects of SNS stimulation, like increasing heart rate and blood pressure.

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Adrenergic Antagonists

Drugs that block the effects of SNS stimulation by binding to SNS receptors.

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Acetylcholine (ACh)

Chemicals released by the PNS that bind to receptors on cells, causing various effects, like slowing heart rate and promoting digestion.

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Antidepressant Effectiveness

Antidepressants take time to work, usually 2 or more weeks to reach peak effectiveness.

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How Antidepressants Work

Antidepressants work by increasing the levels of certain neurotransmitters in the brain.

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SSRIs (Selective Serotonin Reuptake Inhibitors)

They prevent the reuptake of serotonin, increasing its levels in the brain.

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SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)

They inhibit the reuptake of both serotonin and norepinephrine.

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NDRIs (Norepinephrine and Dopamine Reuptake Inhibitors)

They block the reuptake of both norepinephrine and dopamine.

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TCAs (Tricyclic Antidepressants)

They block the reuptake of serotonin and norepinephrine, leading to higher levels of these neurotransmitters.

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MAOIs (Monoamine Oxidase Inhibitors)

They inhibit the breakdown of neurotransmitters like serotonin, norepinephrine, and dopamine, leading to increased levels.

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Side Effects of TCAs

These can cause anticholinergic side effects, such as dry mouth, constipation, and blurred vision.

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Dopamine

A neurotransmitter that plays a crucial role in learning, motor control, reward, emotion, and executive functions. Abnormal levels are linked to several mental health disorders, including Parkinson's disease, addiction, and schizophrenia.

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Glutamate

An excitatory neurotransmitter that is involved in memory and learning. Elevated levels are associated with psychosis, such as schizophrenia and methamphetamine use.

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GABA

A major inhibitory neurotransmitter that slows down overexcited nerve cells. Low levels are associated with conditions like seizures, anxiety, mania, and impulse control.

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Serotonin

A neurotransmitter that modulates mood, sleep, libido, and temperature regulation. Its abnormal levels are linked to depression, bipolar disorder, and anxiety.

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Acetylcholine

A neurotransmitter that stimulates nicotinic and muscarinic receptors in the parasympathetic nervous system. Substances that bind to these receptors have various effects on the body and mind.

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Norepinephrine

A neurotransmitter that affects stress, sleep, attention, and focus by stimulating alpha- and beta-receptors in the sympathetic nervous system.

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What are antidepressants used for?

Antidepressants are medications primarily used to treat depression but also for conditions like anxiety, chronic pain, and insomnia.

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How effective are antidepressants?

Antidepressants generally work well for improving depression symptoms and preventing relapse.

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Benzodiazepines

A class of medications that bind to GABA receptors and increase the inhibitory effects of GABA, leading to a calming effect on the brain and nervous system.

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What are Benzodiazepines used for?

A group of medications commonly used to treat anxiety disorders, their short-term use is ideal for treating acute anxiety and panic attacks, but they can be habit-forming.

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What is a potential side effect of benzodiazepines?

A common side effect associated with benzodiazepines is sedation, which can result in drowsiness, impaired coordination, and slowed reactions.

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How do Beta-blockers help with anxiety?

Beta-blockers are used to manage the physiological symptoms of anxiety, such as trembling, rapid heartbeat, and sweating.

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Antipsychotics

A class of medications primarily used to manage psychosis, a condition characterized by a loss of contact with reality, involving delusions or hallucinations.

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What are antipsychotics used for?

Antipsychotics have various uses beyond psychosis, including management of severe mental conditions such as schizophrenia, bipolar disorder, and severe depression.

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Lithium Toxicity

Lithium toxicity is a serious situation that can occur when lithium levels in the blood exceed 0.8 to 1.2 mEq/L.

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What is lithium used for?

Lithium is a mood-stabilizing medication, commonly used for bipolar disorder, and its effectiveness relies on maintaining safe and therapeutic levels within the body.

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Stimulant Medications for ADHD

Medications used to treat ADHD by increasing levels of dopamine and norepinephrine in the brain. They are often prescribed for children and adults with ADHD but require careful supervision due to potential for misuse.

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Medications for Alcohol Use Disorder

A class of medications used to treat alcohol use disorder. They work by reducing cravings and unpleasant withdrawal symptoms.

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Psychoactive Substances

A category of drugs that affect the mind, emotions, and behavior. These often target the central nervous system and neurotransmitters.

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Substance Withdrawal/Detoxification

This refers to the process of reducing and managing withdrawal symptoms from substance use.

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Controlled Substance

A type of prescription drug that has a high potential for misuse or addiction and is subject to strict regulations.

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Black Box Warning

This warning is issued by the FDA to alert prescribers and patients about serious potential risks associated with a medication.

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Study Notes

Introduction

  • Psychotropic medications affect the mind, emotions, and behavior.
  • Nurses need up-to-date information.
  • Medication information changes frequently and requires consultation of evidence-based resources.
  • DailyMed provides current FDA information on prescription and over-the-counter medications.
  • MedlinePlus is an online resource with easy-to-understand medication information for clients.

Review of the Central Nervous System

  • Understanding CNS anatomy and physiology is crucial for understanding psychotropic medications.
  • The nervous system is divided into the CNS (brain and spinal cord) and the PNS (all other parts).
  • The PNS includes sensory neurons that sense the environment and conduct signals to the brain, and motor neurons that conduct responses from the brain to the peripheral nervous system.
  • The somatic nervous system controls voluntary muscle movements.

Sympathetic and Parasympathetic Nervous System

  • The autonomic nervous system (ANS) is divided into the sympathetic (SNS) and parasympathetic (PNS) nervous systems.
  • The SNS's effects include increased heart rate, blood pressure, and bronchodilation, associated with the “fight-or-flight” response.
  • The PNS’s effects include decreased heart rate, blood pressure, and bronchoconstriction, associated with the "rest-and-digest" response.
  • The SNS and PNS work together to maintain homeostasis.
  • SNS receptors include Alpha-1, Alpha-2, Beta-1, and Beta-2 receptors.
  • Examples of SNS agonist stimulation include those seen in ADHD treatment with medications like methylphenidate.
  • PNS Receptors include Nicotinic and Muscarinic receptors.
  • Cholinergics stimulate nicotinic and muscarinic receptors.
  • Anticholinergics block PNS receptors.

Opioid System

  • The opioid system controls pain, reward, and addictive behaviors.
  • The opioid system includes Mu, Delta, and Kappa receptors.
  • Endogenous peptides (e.g., endorphins) and exogenous opiates (e.g., prescribed or illicit drugs) stimulate these receptors.

Neurotransmitters

  • Neurotransmitters are chemical substances that transmit signals throughout the nervous system.
  • These neurotransmitters play vital roles various mental health conditions like Acetylcholine, Glutamate, GABA, Glycine, Dopamine, Serotonin, Norepinephrine, and Epinephrine.
  • Each Neurotransmitter plays an essential role in various mental health conditions.

Antidepressants

  • Antidepressants treat conditions such as depression, anxiety, chronic pain, and insomnia.
  • They include SSRIs, SNRIs, NDRIs, serotonin antagonist and reuptake inhibitors, TCAs, and MAOIs.
  • First-generation antidepressants (TCAs and MAOIs) have more side effects and are less common in practice compared to newer antidepressants.

Mood Stabilizers

  • Mood stabilizers primarily treat bipolar disorder.
  • Lithium, an example, reduces excitatory neurotransmission and increases inhibitory neurotransmission.
  • Anticonvulsant medications are also used for this purpose.

Antianxiety Medications

  • Antianxiety medications reduce anxiety, panic attacks, or extreme fear.
  • Benzodiazepines are a common class, acting on GABA receptors.
  • Beta-blockers reduce the physical symptoms of anxiety.

Antipsychotics

  • Antipsychotics manage psychosis, a condition characterized by a loss of contact with reality.
  • First-generation antipsychotics block dopamine receptors.
  • Second-generation antipsychotics block dopamine and serotonin receptors.

Stimulants

  • Stimulant medications are used to treat ADHD.
  • Examples include methylphenidate, amphetamine, dextroamphetamine, and lisdexamfetamine dimesylate.
  • They increase norepinephrine and dopamine levels.

Other Medications

  • Other medications are used for substance use disorders or the treatments of side effects of these conditions.
  • Buprenorphine-naloxone, methadone, naltrexone, acamprosate, and disulfiram are examples used in the treatment of substance use disorder.

Glossary

  • Key terms are defined for better understanding of the concepts.

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