Psychological Etiology and Lifestyle Factors in IBD Progression Quiz

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Questions and Answers

Which of the following best describes the proposed etiologies underlying the development of inflammatory bowel disease (IBD)?

  • Infectious, lifestyle, genetic, and immunologic
  • Genetic, infectious, immunologic, psychological, lifestyle, dietary, and medications (correct)
  • Surgical, dietary, genetic, and infectious
  • Lifestyle, dietary, medications, immunologic, and surgical

What is the bimodal distribution of age seen in inflammatory bowel disease (IBD) epidemiology?

  • Children and adolescents
  • Young adults and elderly
  • Adolescents and young adults (correct)
  • Elderly and children

Which genetic polymorphism is involved in pathogen recognition and increases the risk of Crohn’s disease (CD)?

  • OCTN1
  • IL-1B
  • NOD1
  • NOD2 (correct)

What is dysbiosis in the context of inflammatory bowel disease (IBD)?

<p>Increased bacteria promoting inflammation in the GI tract (C)</p> Signup and view all the answers

What is the approximate annual incidence rate of Crohn’s disease (CD) per 100,000 individuals?

<p>6-15.5 (C)</p> Signup and view all the answers

What percentage of patients on chronic corticosteroids require surgery within 1 year?

<p>50% (A)</p> Signup and view all the answers

What is a common clinical sign of Ulcerative Colitis severity?

<p>Hematochezia (D)</p> Signup and view all the answers

Which factor is NOT considered a poor prognostic factor for Ulcerative Colitis?

<p>High serum albumin (A)</p> Signup and view all the answers

What is a common clinical presentation of Crohn's Disease involvement in the colon?

<p>Rectal bleeding (C)</p> Signup and view all the answers

Which of the following is a characteristic of Crohn's Disease according to the text?

<p>&quot;Cobblestone&quot; appearance in the intestines (D)</p> Signup and view all the answers

Which diagnostic method is NOT mentioned in the text for the diagnosis of inflammatory bowel diseases?

<p>Blood pressure measurement (B)</p> Signup and view all the answers

What type of infection needs to be ruled out in patients with chronic inflammatory bowel diseases?

<p>Parasitic infection (D)</p> Signup and view all the answers

Which tool helps determine remission in Crohn's Disease?

<p>Crohn's Disease Activity Index (CDAI) (B)</p> Signup and view all the answers

What is the key difference between clinical response and clinical remission in Crohn's Disease?

<p>Total score reduction by 3 points (C)</p> Signup and view all the answers

Which diagnostic tool is superior for detecting small bowel pathology?

<p>Video capsule endoscopy (B)</p> Signup and view all the answers

What does the Harvey Bradshaw Index measure in Crohn's Disease?

<p>Clinical response to treatment (A)</p> Signup and view all the answers

In Crohn's Disease, what does a CDAI score less than 150 indicate?

<p>Mild-Moderate severity (B)</p> Signup and view all the answers

What is one of the key consequences of a breakdown of the intestinal wall and epithelial barrier?

<p>Increased susceptibility to the microbiome (C)</p> Signup and view all the answers

What does systemic toxicity refer to in the context of Crohn's Disease?

<p>Fever and rigors (D)</p> Signup and view all the answers

What cell type shows a reduction in defensin secretion in the context of the text?

<p>Paneth cells (B)</p> Signup and view all the answers

Which type of immune response is increased in Ulcerative Colitis (UC) according to the text?

<p>Th2 induces humoral response (A)</p> Signup and view all the answers

What is one of the consequences of prolonged inflammation in IBD according to the text?

<p>Epithelial injury (D)</p> Signup and view all the answers

What are the types of immune cells that infiltrate the intestinal epithelium in IBD?

<p>Both innate and adaptive immune cells (B)</p> Signup and view all the answers

Which cytokine shows an increase in levels within the intestinal epithelium in IBD?

<p>Tumor Necrosis Factor-alpha (TNF-alpha) (D)</p> Signup and view all the answers

Which is a local complication of Ulcerative Colitis?

<p>Hemorrhoids (C)</p> Signup and view all the answers

What is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD)?

<p>Erythema nodosum (A)</p> Signup and view all the answers

Which medication is associated with the Hygiene Hypothesis in relation to IBD?

<p>Antibiotics (A)</p> Signup and view all the answers

What is a key feature that distinguishes Ulcerative Colitis from Crohn's Disease?

<p>Rectal bleeding (A)</p> Signup and view all the answers

Which of the following is an important vital sign to assess when suspecting Inflammatory Bowel Disease?

<p>Heart rate (D)</p> Signup and view all the answers

Which diagnostic test is commonly used to assess patients with suspected Ulcerative Colitis?

<p>Stool examinations (A)</p> Signup and view all the answers

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