26 Questions
What type of hydrogen bonds are formed between peptide chains in a beta-pleated sheet?
Interchain
What is the orientation of polypeptide chains in an antiparallel beta-pleated sheet?
Antiparallel
What is the geometry of a peptide bond?
Planar and s-trans
What type of structure is formed by a series of tight reverse turns connecting stretches of the polypeptide chain?
Beta-meander
What is the function of a beta-barrel motif in a protein?
To provide information about the folding of proteins
What is the characteristic of a reverse turn in a protein?
A change in direction of the polypeptide chain
What is the 3-D arrangement of all atoms in a protein molecule?
Tertiary structure
What is the primary structure of a protein?
Order in which amino acids are covalently linked together
In fibrous proteins, what is the arrangement of the atoms of the side chains?
Not specified by the secondary structure
What type of bonds are responsible for the stability of the alpha-helix?
Hydrogen bonds parallel to the helix axis
What is the characteristic of the peptide bond in an alpha-helix?
It is s-trans and planar
What type of bonds are involved in the interactions between side chains in globular proteins?
Hydrogen bonds
What is the unique feature of collagen triple helix?
Three polypeptide chains wrapped around each other
What is the effect of proline on the alpha-helix structure?
It restricts rotation due to its cyclic structure
What is the role of hydroxyproline in collagen triple helix?
It is involved in hydrogen bonding
What is the consequence of strong electrostatic repulsion caused by the proximity of several side chains of like charges?
It disrupts the alpha-helix structure
What is the purpose of X-ray crystallography in determining protein structure?
To produce a diffraction pattern that reveals the 3-D structure of a protein
What type of arrangement is characterized by hydrogen-bonded polypeptide chains?
β-pleated sheet
What is the advantage of Nuclear Magnetic Resonance (NMR) spectroscopy over X-ray crystallography?
It can be used to study protein dynamics
What is the role of peptide bonds in the secondary structure of proteins?
They form covalent bonds between amino acids
What is the role of hydrogen bonding in the tertiary structure of proteins?
It helps to stabilize the tertiary structure
What is the consequence of steric repulsion caused by the proximity of bulky side chains?
It disrupts the alpha-helix structure
What is the repeating sequence of amino acid residues in collagen triple helix?
X-Pro-Gly
What is the linear distance between corresponding points on successive turns of the alpha-helix?
5.4 Å
How many residues are typically found in each turn of the alpha-helix?
3.6 residues
What is the term for the cross-linking of collagen helices that occurs with age?
Covalent bonding
This quiz covers the structure of proteins, focusing on hydrogen bonds between peptide chains. It explains how hydrogen bonds can be interchain or intrachain, leading to a zigzag structure. Test your understanding of protein chemistry!
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