4 Questions
What is the function of the signal recognition particle (SRP) in the secretory pathway?
It binds to the signal peptide emerging from the ribosome and halts translation
Which component of the signal recognition particle (SRP) is involved in binding to the signal peptide?
Different proteins and a small RNA
What is the role of the translocon in the secretory pathway?
It serves as a passageway through the membrane for the ribosome
What is the function of the signal peptidase in the secretory pathway?
It excises the signal peptide from the translated protein
Study Notes
Signal Recognition Particle (SRP)
- SRP is involved in the targeting of proteins to the endoplasmic reticulum (ER) in the secretory pathway
- SRP binds to the signal peptide of the nascent protein, preventing its translation and allowing the ribosome to target the ER membrane
SRP Components
- The SRP54 subunit is involved in binding to the signal peptide of the nascent protein
- This binding causes a pause in protein synthesis, allowing the ribosome to target the ER membrane
Translocon
- The translocon is a protein complex embedded in the ER membrane that forms a channel for protein translocation
- It facilitates the transport of proteins across the ER membrane, and is involved in the co-translational insertion of proteins into the ER
Signal Peptidase
- Signal peptidase is an enzyme that removes the signal peptide from the nascent protein during protein translocation
- This cleavage event is necessary for the maturation of the protein, allowing it to assume its native conformation and function
Test your knowledge about proteins destined for export and the secretory pathway, including their synthesis on membrane-bound ribosomes and the characteristics of their hydrophobic signal peptide.
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