26 Questions
Which drug induces hypnosis or sleep?
Propofol
What is the main advantage of propofol as an anesthetic?
It induces unconsciousness within 30 seconds
What is the purpose of soybean oil in the formulation of propofol?
To emulsify the drug
Which organ is responsible for the rapid and extensive metabolism of propofol?
Liver
What is the major metabolic pathway for propofol?
Glucuronidation
What is the elimination half-time of propofol?
40 to 60 minutes
Which patient population exhibits a decreased rate of plasma clearance of propofol?
Patients older than 60 years of age
Which drug has replaced thiopental for induction of anesthesia in many clinical situations?
Propofol
What is the typical conscious sedation dose of propofol for IV sedation?
75 to 100 mg/kg/minute
Which drug may be added to propofol for continuous IV sedation in selected patients?
Midazolam
Which drug has emerged as the agent of choice for sedation during brief gastrointestinal endoscopy procedures?
Propofol
Which effect of propofol is related to its ability to depress spinal cord activity?
Antipruritic effect
Propofol possesses antiepileptic properties due to its inhibition of which ion channels?
Chloride ion channels
Which formulation of propofol may cause bronchoconstriction in asthmatic patients?
Propofol with metabisulfite
What effect does propofol have on cerebral blood flow and intracranial pressure?
Decreases cerebral blood flow and intracranial pressure
Which of the following is true about the impact of propofol on sympathetic nervous system activation?
Propofol blunts the increase in epinephrine concentration associated with a sudden increase in desflurane concentration.
Which patients may experience exaggerated blood pressure effects from propofol?
All of the above
What is the effect of propofol on heart rate?
Propofol has no effect on heart rate.
What is the risk of bradycardia-related death during propofol anesthesia?
1 in 100,000
Which of the following drugs is frequently added to propofol in attempts to prevent pain with IV injection?
Lidocaine
Which of the following is NOT a difference between Diprivan and generic propofol?
Method of administration
Which of the following is a characteristic of Ampofol, a low-lipid emulsion of propofol?
Contains 5% soybean oil and 0.6% egg lecithin
What is the mechanism of action of propofol?
Selective modulation of GABA A receptors
Which of the following is NOT true about propofol's effect on intraocular pressure?
Propofol increases intraocular pressure during laparoscopic surgery.
Which of the following is NOT true about propofol's effect on coagulation?
Propofol alters tests of coagulation and platelet function.
Which of the following is NOT true about cloudy urine caused by propofol?
Cloudy urine caused by propofol is considered to be detrimental to renal function.
Test your knowledge on the impact of propofol and desflurane on the sympathetic nervous system activation. Explore the effects of propofol and desflurane on epinephrine concentration and cardiovascular responses.
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