Propofol vs
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Questions and Answers

Which drug induces hypnosis or sleep?

  • Soybean oil
  • Methohexital
  • Thiopental
  • Propofol (correct)

What is the main advantage of propofol as an anesthetic?

  • It causes increased plasma triglycerides concentrations
  • It induces unconsciousness within 30 seconds (correct)
  • It supports bacterial growth
  • It is an insoluble drug

What is the purpose of soybean oil in the formulation of propofol?

  • To emulsify the drug (correct)
  • To induce hypnosis
  • To reduce anxiety
  • To support bacterial growth

Which organ is responsible for the rapid and extensive metabolism of propofol?

<p>Liver (B)</p> Signup and view all the answers

What is the major metabolic pathway for propofol?

<p>Glucuronidation (C)</p> Signup and view all the answers

What is the elimination half-time of propofol?

<p>40 to 60 minutes (B)</p> Signup and view all the answers

Which patient population exhibits a decreased rate of plasma clearance of propofol?

<p>Patients older than 60 years of age (D)</p> Signup and view all the answers

Which drug has replaced thiopental for induction of anesthesia in many clinical situations?

<p>Propofol (B)</p> Signup and view all the answers

What is the typical conscious sedation dose of propofol for IV sedation?

<p>75 to 100 mg/kg/minute (A)</p> Signup and view all the answers

Which drug may be added to propofol for continuous IV sedation in selected patients?

<p>Midazolam (D)</p> Signup and view all the answers

Which drug has emerged as the agent of choice for sedation during brief gastrointestinal endoscopy procedures?

<p>Propofol (A)</p> Signup and view all the answers

Which effect of propofol is related to its ability to depress spinal cord activity?

<p>Antipruritic effect (D)</p> Signup and view all the answers

Propofol possesses antiepileptic properties due to its inhibition of which ion channels?

<p>Chloride ion channels (C)</p> Signup and view all the answers

Which formulation of propofol may cause bronchoconstriction in asthmatic patients?

<p>Propofol with metabisulfite (C)</p> Signup and view all the answers

What effect does propofol have on cerebral blood flow and intracranial pressure?

<p>Decreases cerebral blood flow and intracranial pressure (A)</p> Signup and view all the answers

Which of the following is true about the impact of propofol on sympathetic nervous system activation?

<p>Propofol blunts the increase in epinephrine concentration associated with a sudden increase in desflurane concentration. (D)</p> Signup and view all the answers

Which patients may experience exaggerated blood pressure effects from propofol?

<p>All of the above (D)</p> Signup and view all the answers

What is the effect of propofol on heart rate?

<p>Propofol has no effect on heart rate. (B)</p> Signup and view all the answers

What is the risk of bradycardia-related death during propofol anesthesia?

<p>1 in 100,000 (D)</p> Signup and view all the answers

Which of the following drugs is frequently added to propofol in attempts to prevent pain with IV injection?

<p>Lidocaine (C)</p> Signup and view all the answers

Which of the following is NOT a difference between Diprivan and generic propofol?

<p>Method of administration (A)</p> Signup and view all the answers

Which of the following is a characteristic of Ampofol, a low-lipid emulsion of propofol?

<p>Contains 5% soybean oil and 0.6% egg lecithin (D)</p> Signup and view all the answers

What is the mechanism of action of propofol?

<p>Selective modulation of GABA A receptors (A)</p> Signup and view all the answers

Which of the following is NOT true about propofol's effect on intraocular pressure?

<p>Propofol increases intraocular pressure during laparoscopic surgery. (A)</p> Signup and view all the answers

Which of the following is NOT true about propofol's effect on coagulation?

<p>Propofol alters tests of coagulation and platelet function. (D)</p> Signup and view all the answers

Which of the following is NOT true about cloudy urine caused by propofol?

<p>Cloudy urine caused by propofol is considered to be detrimental to renal function. (D)</p> Signup and view all the answers

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