16 Questions
What is the primary mechanism of action for prokinetic agents?
Enhancing the release of acetylcholine to increase smooth muscle contractility
Which of the following is NOT a common side effect associated with metoclopramide?
Increased gastrointestinal motility
What is the primary advantage of domperidone over metoclopramide?
Domperidone is a cheaper alternative to metoclopramide
Why was tegaserod withdrawn from the market in 2007?
It was associated with cardiovascular safety concerns
What is the primary mechanism of action for metoclopramide?
Antagonizing dopamine 2 receptors to enhance acetylcholine release
What was the conclusion of the pooled analysis of 13 controlled studies on tegaserod?
Tegaserod was safe and consistently efficacious for chronic constipation, and its cardiovascular safety will be confirmed in larger studies
What is the primary mechanism of action of metoclopramide?
It enhances cholinergic activity by acting at multiple sites, including directly or via dopamine2 receptor blockade
Which of the following statements about metoclopramide is true?
It is more effective in promoting gastric emptying in healthy subjects than in patients receiving long-term anticholinergic therapy
Which of the following statements about prucalopride is accurate?
It is a medication used to treat constipation that has mild and transient side effects such as headache and diarrhea
What led to the withdrawal of tegaserod from use in 2007?
Concerns about its cardiovascular safety, as studies found it increased the risk of cardiovascular events
Which of the following statements about cisapride is false?
It has been reported to consistently improve fecal incontinence in the elderly
Which of the following statements about metoclopramide is true?
It may cause relaxation of the sphincter in some patients
Based on the information provided, which of the following statements about tegaserod is accurate?
It was recommended for use in patients with irritable bowel syndrome-constipation (IBS-C)
Which of the following statements about prucalopride is true?
It is currently under close monitoring due to concerns about its potential to cause severe hepatic impairment
Based on the information provided, which of the following statements about cisapride is accurate?
It has been reported to worsen fecal incontinence and increase the likelihood of this side effect occurring in the elderly
According to the information provided, which of the following statements about metoclopramide is false?
It has been shown to consistently increase the frequency of contractions and phasic activity of the colon
Learn about prokinetic agents, medications that enhance gastrointestinal motility and tone by increasing smooth muscle contractility. Explore the types of prokinetic agents like dopamine receptor antagonists metoclopramide and domperidone, their uses, and side effects.
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