Prokinetic Agents in Gastrointestinal Health
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Questions and Answers

What is the primary mechanism of action for prokinetic agents?

  • Stimulating dopamine 2 receptors to inhibit enteric neuron activity
  • Enhancing the release of acetylcholine to increase smooth muscle contractility (correct)
  • Antagonizing 5HT-4 receptors to reduce visceral hypersensitivity
  • Inhibiting the release of acetylcholine to decrease smooth muscle contractility

Which of the following is NOT a common side effect associated with metoclopramide?

  • Increased gastrointestinal motility (correct)
  • Fatigue
  • Extrapyramidal effects
  • Drowsiness

What is the primary advantage of domperidone over metoclopramide?

  • Domperidone is a cheaper alternative to metoclopramide (correct)
  • Domperidone has a lower incidence of side effects
  • Domperidone acts centrally while metoclopramide acts peripherally
  • Domperidone is a serotonin receptor agonist while metoclopramide is a dopamine receptor antagonist

Why was tegaserod withdrawn from the market in 2007?

<p>It was associated with cardiovascular safety concerns (B)</p> Signup and view all the answers

What is the primary mechanism of action for metoclopramide?

<p>Antagonizing dopamine 2 receptors to enhance acetylcholine release (A)</p> Signup and view all the answers

What was the conclusion of the pooled analysis of 13 controlled studies on tegaserod?

<p>Tegaserod was safe and consistently efficacious for chronic constipation, and its cardiovascular safety will be confirmed in larger studies (D)</p> Signup and view all the answers

What is the primary mechanism of action of metoclopramide?

<p>It enhances cholinergic activity by acting at multiple sites, including directly or via dopamine2 receptor blockade (C)</p> Signup and view all the answers

Which of the following statements about metoclopramide is true?

<p>It is more effective in promoting gastric emptying in healthy subjects than in patients receiving long-term anticholinergic therapy (D)</p> Signup and view all the answers

Which of the following statements about prucalopride is accurate?

<p>It is a medication used to treat constipation that has mild and transient side effects such as headache and diarrhea (B)</p> Signup and view all the answers

What led to the withdrawal of tegaserod from use in 2007?

<p>Concerns about its cardiovascular safety, as studies found it increased the risk of cardiovascular events (D)</p> Signup and view all the answers

Which of the following statements about cisapride is false?

<p>It has been reported to consistently improve fecal incontinence in the elderly (C)</p> Signup and view all the answers

Which of the following statements about metoclopramide is true?

<p>It may cause relaxation of the sphincter in some patients (D)</p> Signup and view all the answers

Based on the information provided, which of the following statements about tegaserod is accurate?

<p>It was recommended for use in patients with irritable bowel syndrome-constipation (IBS-C) (A)</p> Signup and view all the answers

Which of the following statements about prucalopride is true?

<p>It is currently under close monitoring due to concerns about its potential to cause severe hepatic impairment (B)</p> Signup and view all the answers

Based on the information provided, which of the following statements about cisapride is accurate?

<p>It has been reported to worsen fecal incontinence and increase the likelihood of this side effect occurring in the elderly (B)</p> Signup and view all the answers

According to the information provided, which of the following statements about metoclopramide is false?

<p>It has been shown to consistently increase the frequency of contractions and phasic activity of the colon (D)</p> Signup and view all the answers

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