28 Questions
What is the mechanism of action of 5-HT 3 receptor antagonists in reducing visceral afferent sensation?
Inhibition of afferent gastrointestinal 5-HT 3 receptors
Which medication is approved for the treatment of patients with severe IBS with diarrhea?
Alosetron
What is the indication for tegaserod?
Short-term treatment of women with IBS who had predominant constipation
Why was tegaserod voluntarily removed from the market?
Increased number of cardiovascular deaths
Which medication is used in the treatment of chronic constipation?
Lubiprostone
What is the mechanism of action of lubiprostone?
Stimulation of the type 2 chloride channel
Which type of receptor is antagonized by alosetron?
5-HT 3 receptor
What is the indication for lubiprostone in IBS treatment?
Women with IBS with predominant constipation
Which medication is used in the treatment of women with severe IBS with diarrhea?
Alosetron
What is the effect of blockade of central 5-HT 3 receptors?
Reduced central response to visceral afferent stimulation
What is the effect of metoclopramide on 5-HT4-receptors?
Enhances ACh release
Which type of antibiotic directly stimulates motilin receptors on gastrointestinal smooth muscle?
Macrolide
What is the characteristic of irritable bowel syndrome (IBS)?
Idiopathic chronic disorder
What is the mechanism of action of itopride?
Antidopaminergic and anti-acetylcholinesterase
What is the goal of pharmacologic therapies for IBS?
To relieve abdominal pain and improve bowel function
What is the effect of macrolides in patients with gastroparesis?
Rapidly develops tolerance
What is the primary function of Lactobacillus acidophilus in the gut?
To balance potentially harmful bacteria and maintain a healthy gut microbiome
What is the major cause of diarrhea and colitis in patients exposed to antibiotics?
Clostridium difficile infection
What is the benefit of probiotic supplements like Lactobacillus acidophilus?
Balancing the gut microbiome and reducing harmful bacteria
What is the concern with using antidiarrheal agents in patients with fever?
They may mask the underlying cause of the fever
What is the benefit of using Super ORS compared to traditional ORS?
It reduces the frequency of diarrhea along with rehydration
What is the mechanism of action of adsorbents like kaolin and pectin?
They coat the GI tract wall and adsorb toxins and bacteria
What is the effect of 5-HT 3 receptor antagonists on visceral afferent sensation?
Reduce unpleasant visceral afferent sensation
What is the indication for alosetron?
Severe IBS with diarrhea
What is the mechanism of action of lubiprostone?
Stimulates the type 2 chloride channel
What is the current status of tegaserod?
It was voluntarily removed from the market
Which medication is used in the treatment of women with IBS with predominant constipation?
Lubiprostone
What is the effect of 5-HT 3 receptor antagonists on the central nervous system?
Reduce the central response to visceral afferent stimulation
Test your knowledge of prokinetic agents, their mechanisms of action, and their effects on the gastrointestinal system. Learn about the role of metoclopramide and macrolide antibiotics in stimulating the small intestine and their potential benefits in treating postoperative ileus and chronic intestinal pseudo-obstruction.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
