Questions and Answers
What is the trade name of Prochlorperazine?
Which of the following classes does Prochlorperazine belong to? (Select all that apply)
What are the indications for the use of Prochlorperazine? (Select all that apply)
What effect does Prochlorperazine have on nausea and vomiting?
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In which conditions is Prochlorperazine contraindicated?
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What precautions should be considered when administering Prochlorperazine? (Select all that apply)
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Which of the following are adverse effects of Prochlorperazine? (Select all that apply)
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What is an important assessment while on Prochlorperazine?
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What lab considerations should be evaluated periodically during Prochlorperazine therapy? (Select all that apply)
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What teaching should be provided to patients taking Prochlorperazine?
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Study Notes
Prochlorperazine Overview
- Trade name: Compazine
- Classifications include antiemetics, antipsychotics, and phenothiazines.
Indications
- Used for managing nausea and vomiting.
- Effective in treating psychoses.
- Helps alleviate anxiety symptoms.
Mechanism of Action
- Reduces nausea and vomiting.
- Alleviates signs and symptoms of psychoses and anxiety.
Contraindications
- Hypersensitivity to prochlorperazine or phenothiazines.
- Conditions like angle-closure glaucoma, severe liver or cardiovascular disease.
- Avoid in patients with bone marrow depression or hypersensitivity to bisulfites/benzyl alcohol.
- Not recommended for children aged 2 years and under or weighing 9.1 kg and under.
Cautions
- Use with caution in patients with diabetes, respiratory disease, or prostatic hypertrophy.
- Consider risks associated with CNS tumors, epilepsy, and intestinal obstruction.
- Safety during pregnancy and lactation is not established.
- Geriatric patients may require dose adjustments due to increased mortality risk.
Adverse Effects
- Serious risks include neuroleptic malignant syndrome and agranulocytosis.
- Other potential effects: sedation, extrapyramidal reactions, tardive dyskinesia, blurred vision, dry eyes, and urinary retention.
- Notable symptoms: hypotension, tachycardia, and changes in urine color.
Drug Interactions
- May cause additive hypotension with antihypertensives or alcohol.
- Increased CNS depression when combined with other depressants (alcohol, opioids).
- Risk of extra-pyramidal reactions if taken with lithium.
- Antacids may reduce absorption, potentially affecting efficacy.
Assessment Practices
- Monitor vital signs, including BP, ECG, pulse, and respiratory rate.
- Regular checks for sedation levels and signs of akathisia or extrapyramidal side effects.
- Assess for tardive dyskinesia and neuroleptic malignant syndrome; immediate reporting required.
- Evaluate patient mental status periodically throughout therapy.
Laboratory Considerations
- Periodic evaluation of CBC and liver function tests is necessary.
- Watch for blood dyscrasias, especially between weeks 4 and 10.
- Hepatotoxicity risks are highest between weeks 2 and 4, with recurrence possible upon restarting.
Patient Education
- Inform about potential side effects, including extrapyramidal symptoms and tardive dyskinesia.
- Advise gradual position changes to prevent orthostatic hypotension.
- Recommend good oral hygiene to manage dry mouth; consult if symptoms persist.
- Instruct against taking with antacids or antidiarrheal drugs within 2 hours.
- Promote increased fiber and hydration to mitigate constipation risks.
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Description
Test your knowledge of Prochlorperazine with these flashcards. Learn about its trade name, classification, indications, actions, and contraindications. Ideal for those studying pharmacology or related health fields.
