Questions and Answers
What are the indications for Compazine?
It is used to treat psychotic disorders such as schizophrenia, anxiety, and to control severe nausea and vomiting.
What are the contraindications for Compazine?
Hypersensitivity, coma, severe CNS depression, concurrent use of large amounts of CNS depressants, poorly controlled seizure disorder, subcortical brain damage, children under 2 years old or weighing less than 9 kg.
What is the mechanism of action of Compazine?
Antipsychotic: Blocking mesolimbic dopamine receptors and blocking alpha-adrenergic receptors in the brain. Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain and blocking the vagus nerve in the GI tract.
What are the trade and generic names for Compazine?
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What is the dosage for Compazine for severe nausea and vomiting?
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What are the routes of administration for Compazine?
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What are some adverse reactions and side effects of Compazine?
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What drug classifications does Compazine belong to?
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Study Notes
Indications
- Treats psychotic disorders, including schizophrenia.
- Manages anxiety symptoms.
- Controls severe nausea and vomiting.
Contraindications
- Not for use in cases of hypersensitivity or coma.
- Avoid with severe CNS depression and large concurrent use of CNS depressants.
- Caution in poorly controlled seizure disorders and subcortical brain damage.
- Not recommended for children under 2 years or weighing less than 9 kg.
- Should not be used for postoperative nausea/vomiting after pediatric surgery.
Mechanism of Action
- Functions as an antipsychotic by blocking mesolimbic dopamine receptors and alpha-adrenergic receptors (D1 and D2).
- Acts as an antiemetic by exerting antidopaminergic effects, blocking dopamine receptors in the brain and vagus nerve in the gastrointestinal tract.
Trade and Generic Name
- Trade name: Compazine.
- Generic name: prochlorperazine.
Dosage
- For severe nausea and vomiting:
- Oral: Immediate-release (5-10 mg every 6-8 hours), Extended-release (10 mg every 12 hours or 15 mg every morning).
- Suppository: 25 mg every 12 hours.
- Intramuscular (IM): 5-10 mg every 3-4 hours (max 40 mg/day).
- Intravenous (IV): 2.5-10 mg every 3-4 hours (max 10 mg/day).
- For psychosis:
- Oral: 5-10 mg every 6-8 hours, with slow dose titration (max 150 mg/day).
- IM: 10-20 mg every 2-4 hours (rarely need 3-4 doses).
Administration
- Available in oral, intramuscular (IM), intravenous (IV), and suppository forms.
Adverse Reactions and Side Effects
- Common side effects include drowsiness, dizziness, amenorrhea (absence of menstruation), blurred vision, skin reactions, and hypotension.
Drug Classification
- Classified as antiemetic agents, antipsychotics, and phenothiazines.
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Description
This quiz covers the indications, contraindications, mechanisms of action, and dosage of Prochlorperazine, an antipsychotic and antiemetic drug. Test your understanding of its clinical uses and safety considerations.
