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Questions and Answers
What is the class of Compazine?
What is the class of Compazine?
- Phenothiazine (correct)
- SSRI
- Benzodiazepine
- Antidepressant
What is the mechanism of action (MOA) of Compazine?
What is the mechanism of action (MOA) of Compazine?
Blocks dopamine receptors
Which of the following are precautions associated with Compazine? (Select all that apply)
Which of the following are precautions associated with Compazine? (Select all that apply)
- Drowsiness
- Weight gain
- Tremors (correct)
- EPS - Dystonia (correct)
Compazine may cause ________ as a side effect.
Compazine may cause ________ as a side effect.
Name two side effects of Compazine.
Name two side effects of Compazine.
What type of interactions does Compazine have?
What type of interactions does Compazine have?
The recommended dose of Compazine is ________ mg IV that may be repeated in 10 minutes.
The recommended dose of Compazine is ________ mg IV that may be repeated in 10 minutes.
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Study Notes
Compazine Overview
- Compazine is classified as a phenothiazine, primarily used as an antiemetic medication.
Mechanism of Action (MOA)
- Works by blocking dopamine receptors in the brain, reducing nausea and vomiting.
Precautions
- Use caution due to the risk of extrapyramidal symptoms (EPS), which can include dystonia, tremors, and chorea.
- Benadryl can be used to alleviate symptoms of EPS.
Side Effects
- Common side effects include:
- Drowsiness
- Sedation
- Tachycardia (increased heart rate)
- Bradycardia (decreased heart rate)
- Dizziness
- Agitation
Drug Interactions
- Can have a potentiating effect when used with central nervous system (CNS) depressants and monoamine oxidase inhibitors (MAOIs).
Dosage Information
- For intravenous administration, a dose of 5-10 mg can be given and may be repeated once after 10 minutes.
- For intramuscular administration, 5 mg can be given with the option to repeat once after 10 minutes.
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