Principles of Pharmacokinetics - Drug Delivery Systems Quiz
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Questions and Answers

What is the target in pharmacokinetics, generally?

  • Maximum effect concentration (MEC)
  • Plasma/blood drug concentration (correct)
  • Drug absorption, distribution, metabolism, and excretion
  • Minimum toxic concentration (MTC)

    • In pharmacokinetics, what must the desired steady-state Cp be in order to be effective clinically but not toxic?

  • Greater than the MEC and less than the MTC (correct)
  • Equal to the MTC
  • Lower than the MTC
  • Equal to the MEC

    • What does the pharmacokinetic model translate the dose into?

  • MEC
  • MTC
  • Plasma concentration (correct)
  • Drug absorption

    • What does the pharmacodynamic model convert the drug concentration at the effect site into?

    <p>Measured effect</p> Signup and view all the answers

    What is the primary focus of pharmaceutical scientists in biopharmaceutics?

    <p>Drug delivery systems</p> Signup and view all the answers

    What is the theoretical framework of principles for determining the time course of drug absorption, distribution, metabolism, and excretion?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What is the primary focus of most drug delivery devices in terms of achieving concentration?

    <p>Achieving steady-state drug plasma concentration (Cp,ss)</p> Signup and view all the answers

    Which process is critical to the development of various drug delivery technologies?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What does LADME stand for in the context of drug pharmacokinetics?

    <p>Liberation, Absorption, Distribution, Metabolism, Excretion</p> Signup and view all the answers

    What does liberation encompass in the LADME scheme?

    <p>All kinetic aspects related to the liberation of drug from its dosage form into its active or desired form</p> Signup and view all the answers

    In what circumstances is there no absorption process following drug administration?

    <p>Intravenous bolus injection of the drug</p> Signup and view all the answers

    What processes reflect drug absorption, distribution, and elimination following drug administration?

    <p>Absorption, distribution, and elimination</p> Signup and view all the answers

    What is the relationship between Cp and the corresponding effect for most drugs?

    <p>$Cp$ is in one-to-one correspondence with the corresponding effect</p> Signup and view all the answers

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