13 Questions
What is the target in pharmacokinetics, generally?
Plasma/blood drug concentration
In pharmacokinetics, what must the desired steady-state Cp be in order to be effective clinically but not toxic?
Greater than the MEC and less than the MTC
What does the pharmacokinetic model translate the dose into?
Plasma concentration
What does the pharmacodynamic model convert the drug concentration at the effect site into?
Measured effect
What is the primary focus of pharmaceutical scientists in biopharmaceutics?
Drug delivery systems
What is the theoretical framework of principles for determining the time course of drug absorption, distribution, metabolism, and excretion?
Pharmacokinetics
What is the primary focus of most drug delivery devices in terms of achieving concentration?
Achieving steady-state drug plasma concentration (Cp,ss)
Which process is critical to the development of various drug delivery technologies?
Pharmacokinetics
What does LADME stand for in the context of drug pharmacokinetics?
Liberation, Absorption, Distribution, Metabolism, Excretion
What does liberation encompass in the LADME scheme?
All kinetic aspects related to the liberation of drug from its dosage form into its active or desired form
In what circumstances is there no absorption process following drug administration?
Intravenous bolus injection of the drug
What processes reflect drug absorption, distribution, and elimination following drug administration?
Absorption, distribution, and elimination
What is the relationship between Cp and the corresponding effect for most drugs?
$Cp$ is in one-to-one correspondence with the corresponding effect
Test your knowledge on the principles of pharmacokinetics and drug delivery systems with this quiz. Explore the theoretical framework for determining the time course of drug absorption, distribution, metabolism, and excretion (ADME) in the body.
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