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Principles of Pharmacokinetics - Drug Delivery Systems Quiz

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Principles of Pharmacokinetics - Drug Delivery Systems Quiz

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Questions and Answers

What is the target in pharmacokinetics, generally?

Maximum effect concentration (MEC)

Plasma/blood drug concentration (correct)

Drug absorption, distribution, metabolism, and excretion

Minimum toxic concentration (MTC)

In pharmacokinetics, what must the desired steady-state Cp be in order to be effective clinically but not toxic?

Greater than the MEC and less than the MTC (correct)

Equal to the MTC

Lower than the MTC

Equal to the MEC

What does the pharmacokinetic model translate the dose into?

MEC

MTC

Plasma concentration (correct)

Drug absorption

What does the pharmacodynamic model convert the drug concentration at the effect site into?

Measured effect Signup and view all the answers

What is the primary focus of pharmaceutical scientists in biopharmaceutics?

Drug delivery systems Signup and view all the answers

What is the theoretical framework of principles for determining the time course of drug absorption, distribution, metabolism, and excretion?

Pharmacokinetics Signup and view all the answers

What is the primary focus of most drug delivery devices in terms of achieving concentration?

Achieving steady-state drug plasma concentration (Cp,ss) Signup and view all the answers

Which process is critical to the development of various drug delivery technologies?

Pharmacokinetics Signup and view all the answers

What does LADME stand for in the context of drug pharmacokinetics?

Liberation, Absorption, Distribution, Metabolism, Excretion Signup and view all the answers

What does liberation encompass in the LADME scheme?

All kinetic aspects related to the liberation of drug from its dosage form into its active or desired form Signup and view all the answers

In what circumstances is there no absorption process following drug administration?

Intravenous bolus injection of the drug Signup and view all the answers

What processes reflect drug absorption, distribution, and elimination following drug administration?

Absorption, distribution, and elimination Signup and view all the answers

What is the relationship between Cp and the corresponding effect for most drugs?

$Cp$ is in one-to-one correspondence with the corresponding effect Signup and view all the answers