Primidone Pharmacology Quiz

Primidone Overview

• Primidone is marketed under the trade name Mysoline.
• Classification falls under Category D, indicating potential risks during pregnancy, and it is classified as an anticonvulsant.

Indications and Therapeutic Use

• Primidone is primarily indicated for the treatment of essential tremor.

Mechanism of Action

• It functions by decreasing neuronal excitability.
• It increases the threshold for electric stimulation in the motor cortex, which can help manage symptoms.

Dosage Information

• The safe dosage commonly prescribed is 100-125 mg taken at bedtime.

Contraindications

• Not suitable for patients with hypersensitivity to primidone or phenobarbital.
• Contraindicated in individuals with porphyria.

Precautions

• All patients on Primidone should be monitored for increased risk of suicidal thoughts.
• Caution is advised in cases of severe liver disease.

Adverse Effects

• May cause suicidal thoughts, ataxia, drowsiness, and vertigo.
• Other potential side effects include anorexia, visual changes, dyspnea, edema, and orthostatic hypotension.
• Could lead to serious issues like drug-induced hepatitis, nausea/vomiting, alopecia, rash, blood dyscrasias, megaloblastic anemia, and folic acid deficiency.

Assessment and Monitoring

• Regular assessment of seizure activity is crucial.
• Evaluate for signs of folic acid deficiency.
• Monitor for any significant changes in patient behavior.

Patient Teaching

• Inform patients about the possibility of behavioral changes and drowsiness.
• Advise taking missed doses as soon as possible within one hour of the next dose.
• Patients should notify healthcare providers before undergoing treatment or surgery.