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Questions and Answers
What is the primary mechanism by which 5-FU inhibits DNA synthesis?
What is the primary mechanism by which 5-FU inhibits DNA synthesis?
- By directly binding to DNA
- By inhibiting the conversion of uracil to thymine
- By inhibiting thymidylate synthase activity (correct)
- By inhibiting RNA polymerase activity
What is the primary type of cancer that 5-FU is employed to treat?
What is the primary type of cancer that 5-FU is employed to treat?
- Slow-growing solid tumors (correct)
- Chronic myeloid leukemia
- Hodgkin's lymphoma
- Acute lymphoblastic leukemia
What is the result of 5-FU's inhibition of thymidylate synthase?
What is the result of 5-FU's inhibition of thymidylate synthase?
- Increased production of thymidine
- Decreased production of uracil
- Increased production of cytosine
- Deprivation of the cell of thymidine (correct)
What is the role of the fluorine atom in 5-FU?
What is the role of the fluorine atom in 5-FU?
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What is the purpose of capecitabine in the treatment of cancer?
What is the purpose of capecitabine in the treatment of cancer?
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Which of the following pyrimidine inhibitors is an analog of 2′-deoxycytidine?
Which of the following pyrimidine inhibitors is an analog of 2′-deoxycytidine?
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What is the primary mechanism of action of Ara-CTP in DNA synthesis?
What is the primary mechanism of action of Ara-CTP in DNA synthesis?
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Why is cytarabine not effective when given orally?
Why is cytarabine not effective when given orally?
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What is the primary clinical use of azacitidine?
What is the primary clinical use of azacitidine?
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What is the primary mechanism of action of gemcitabine?
What is the primary mechanism of action of gemcitabine?
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