10 Questions
What is the primary mechanism by which 5-FU inhibits DNA synthesis?
By inhibiting thymidylate synthase activity
What is the primary type of cancer that 5-FU is employed to treat?
Slow-growing solid tumors
What is the result of 5-FU's inhibition of thymidylate synthase?
Deprivation of the cell of thymidine
What is the role of the fluorine atom in 5-FU?
It interferes with the conversion of deoxyuridylic acid to thymidylic acid
What is the purpose of capecitabine in the treatment of cancer?
To inhibit DNA synthesis
Which of the following pyrimidine inhibitors is an analog of 2′-deoxycytidine?
Cytarabine
What is the primary mechanism of action of Ara-CTP in DNA synthesis?
Inhibition of DNA polymerase
Why is cytarabine not effective when given orally?
It is broken down by cytidine deaminase in the intestinal mucosa and liver
What is the primary clinical use of azacitidine?
Myelodysplastic syndromes and AML
What is the primary mechanism of action of gemcitabine?
Inhibition of DNA polymerase
This quiz covers pyrimidine analogs, a type of chemotherapeutic agent that inhibits DNA and RNA synthesis. Learn about the two groups of pyrimidine analogs, thymidine and cytosine inhibitors, and their respective examples, including 5-fluorouracil and cytarabine.
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