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Pharmokinectics exam 2
39 Questions
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Pharmokinectics exam 2

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Questions and Answers

What's the primary site of absorption after oral administration?

  • Liver
  • Small intestines (correct)
  • Kidney
  • Stomach

    • Extended-release formulations are devised to control drug release at a reduced rate (Ka < K ), resulting in ____ drug level in plasma

    sustained

    How many half lives for a drug to reach steady state?

  • 2
  • 12
  • 8
  • 5 (correct)

    • Oral ______ ( F ) is determined by comparing the drug exposure following PO with that of IV dosing

    <p>Oral bioavailability ( F ) is determined by comparing the drug exposure following PO with that of IV dosing</p> Signup and view all the answers

    Which of these Drugs is not CV?

    <p>Perampanel</p> Signup and view all the answers

    Which of these drugs in CIII

    <p>Perampanel</p> Signup and view all the answers

    Which of these drugs Lowers BC concentrations

    <p>Rufanimide</p> Signup and view all the answers

    Which of these drugs does NOT lower oral contraception concentration?

    <p>Lacosamide</p> Signup and view all the answers

    The T2 of focal seizures is ___ minutes

    <p>60</p> Signup and view all the answers

    Which is NOT an initial treatment choice for status epilectus?

    <p>PO phentobarbitol</p> Signup and view all the answers

    Which of these is first line for absence seizures

    <p>All of these are first line</p> Signup and view all the answers

    Which is NOT first line for tonic clonic seizures

    <p>Levetiracetem</p> Signup and view all the answers

    Which does NOT have a sodium factor of 1

    <p>Fosphenytoin injection</p> Signup and view all the answers

    Which is a warning of lacosamide?

    <p>Prolongs PR interval</p> Signup and view all the answers

    Which is true about Ethosuximide?

    <p>It can cause lupus as an adverse event</p> Signup and view all the answers

    Which ASM is contraindicationed in sufla allergies

    <p>Zonisamide</p> Signup and view all the answers

    Which has the lowest risk of hyponatremia

    <p>Esliscarbazepine</p> Signup and view all the answers

    T/F: Hyponatremia is more common with Oxcarbazepine than with Carbmazepine?

    <p>True</p> Signup and view all the answers

    Which is a UGT inhibitor

    <p>Valproate</p> Signup and view all the answers

    What is the therapeutic range of Valproate?

    <p>50-100 mg/l</p> Signup and view all the answers

    Match the valproate concentration with what happens

    <blockquote> <p>50 = therapeutic range 75 = Ataxia, sedation, lethargy 100 = tremor 175 = stupor, coma</p> </blockquote> Signup and view all the answers

    What's the average valproate clearance for adults with liver failure

    <p>3-4 mL/h/kg</p> Signup and view all the answers

    What's the average valproate clearance for normal adults

    <p>7-12 mL/h/kg</p> Signup and view all the answers

    Which form of Topiramate should alcohol be avoided for 6 hours before and after taking

    <p>Trokendi</p> Signup and view all the answers

    Which has a box warning for serious neuropsychiatric events?

    <p>Perampanel</p> Signup and view all the answers

    If child-pugh score is >___, reduce valproate dose by ___ %

    <p>8, 25-50%</p> Signup and view all the answers

    If you want to increase concentration of Valproate, increase dose by ___ % of predicted dose

    <p>10-20</p> Signup and view all the answers

    T/F: Cirrhosis decrease volume of distribution

    <p>False</p> Signup and view all the answers

    What's the average volume of distribution for phenytoin

    <p>0.65 L/kg</p> Signup and view all the answers

    T/F: Carbamazepine and phenytoin are UGT inducers

    <p>True</p> Signup and view all the answers

    Which ASM is NOT contraindicated in Familial Short QT syndrome

    <p>Epidolex</p> Signup and view all the answers

    Primidone is metablized by CYP____ into Phentobarbital and PEMA

    <p>CYP2C9</p> Signup and view all the answers

    T/F: Pentobarbital is a GABA-A Pam that increases channel opening time

    <p>True</p> Signup and view all the answers

    Which drug is an NMDA-R blocker

    <p>Felbamate</p> Signup and view all the answers

    Felbamate should be discontinued if ___ are 2x normal upper limit normal

    <p>LFTs</p> Signup and view all the answers

    What is a common first-line agent for focal seziures according to the text?

    <p>Levetiracetam (Keppra)</p> Signup and view all the answers

    Which drug DOES NOT require renal dose adjustments?

    <p>Lamotrigine</p> Signup and view all the answers

    Which drug should be taken with food?

    <p>All of them should be taken with food</p> Signup and view all the answers

    Pregnant women suffering from tonic clonic seizures. Pick the best one to give her

    <p>Lamotrigine</p> Signup and view all the answers

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