Praziquantel and Schistosomiasis

Play Quiz

Study Flashcards

Spaced Repetition

Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Download our mobile app to listen on the go

Get App

No, some may not be trustworthy (B) Signup and view all the answers

No, it may not be curative (C) Signup and view all the answers

No, it does not act on either ova or immature worms (C) Signup and view all the answers

No, it has not been convincingly demonstrated (B) Signup and view all the answers

Flashcards are hidden until you start studying

Praziquantel is the drug of choice for treating schistosomiasis and other flukes and cestodes.
It works by provoking tetanic contraction of adult worms and damaging their tegument.
Humoral and cellular immune responses enhance the drug effect.
Side effects are mild and include nausea, vomiting, malaise, and abdominal pain.
Dozens of generic brands of praziquantel exist, not all of which are of trustworthy quality.
The standard single dose of 40 mg/kg may not be curative and higher-dose regimens should be given in split doses.
Praziquantel does not act on ova or immature worms.
Most schistosome-induced pathology resolves after praziquantel treatment.
True drug resistance to praziquantel has not been convincingly demonstrated.
Derivatives of artemisinin have shown effectiveness against immature stages of schistosomiasis.