Praziquantel and Schistosomiasis

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Questions and Answers

What is the drug of choice for treating schistosomiasis and other flukes and cestodes?

Praziquantel (correct)
Mebendazole
Albendazole
Ivermectin

How does praziquantel work?

By inhibiting the growth of adult worms
By causing the adult worms to contract and damaging their tegument (correct)
By enhancing the immune system's response to the worms
By attacking the ova of the worms

What are the common side effects of praziquantel?

Nausea, vomiting, malaise, and abdominal pain (correct)
Headaches and dizziness
Skin rash and itching
Joint pain and muscle weakness

Are all generic brands of praziquantel trustworthy?

No, some may not be trustworthy (B) Signup and view all the answers

Is the standard single dose of praziquantel always curative?

No, it may not be curative (C) Signup and view all the answers

Does praziquantel act on ova or immature worms?

No, it does not act on either ova or immature worms (C) Signup and view all the answers

Has true drug resistance to praziquantel been demonstrated?

No, it has not been convincingly demonstrated (B) Signup and view all the answers

Study Notes

Praziquantel is the drug of choice for treating schistosomiasis and other flukes and cestodes.
It works by provoking tetanic contraction of adult worms and damaging their tegument.
Humoral and cellular immune responses enhance the drug effect.
Side effects are mild and include nausea, vomiting, malaise, and abdominal pain.
Dozens of generic brands of praziquantel exist, not all of which are of trustworthy quality.
The standard single dose of 40 mg/kg may not be curative and higher-dose regimens should be given in split doses.
Praziquantel does not act on ova or immature worms.
Most schistosome-induced pathology resolves after praziquantel treatment.
True drug resistance to praziquantel has not been convincingly demonstrated.
Derivatives of artemisinin have shown effectiveness against immature stages of schistosomiasis.

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Description

"Think you know everything about praziquantel and its role in treating schistosomiasis? Test your knowledge with our quiz! From its mechanism of action to dosing regimens and potential side effects, this quiz covers all the key facts about this important drug. Plus, learn about the latest research on artemisinin derivatives and their potential for treating schistosomiasis. Sharpen your expertise in parasitology and take the quiz now!"