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Questions and Answers
What is the drug of choice for treating schistosomiasis and other flukes and cestodes?
What is the drug of choice for treating schistosomiasis and other flukes and cestodes?
- Praziquantel (correct)
- Mebendazole
- Albendazole
- Ivermectin
How does praziquantel work?
How does praziquantel work?
- By inhibiting the growth of adult worms
- By causing the adult worms to contract and damaging their tegument (correct)
- By enhancing the immune system's response to the worms
- By attacking the ova of the worms
What are the common side effects of praziquantel?
What are the common side effects of praziquantel?
- Nausea, vomiting, malaise, and abdominal pain (correct)
- Headaches and dizziness
- Skin rash and itching
- Joint pain and muscle weakness
Are all generic brands of praziquantel trustworthy?
Are all generic brands of praziquantel trustworthy?
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Is the standard single dose of praziquantel always curative?
Is the standard single dose of praziquantel always curative?
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Does praziquantel act on ova or immature worms?
Does praziquantel act on ova or immature worms?
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Has true drug resistance to praziquantel been demonstrated?
Has true drug resistance to praziquantel been demonstrated?
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Study Notes
- Praziquantel is the drug of choice for treating schistosomiasis and other flukes and cestodes.
- It works by provoking tetanic contraction of adult worms and damaging their tegument.
- Humoral and cellular immune responses enhance the drug effect.
- Side effects are mild and include nausea, vomiting, malaise, and abdominal pain.
- Dozens of generic brands of praziquantel exist, not all of which are of trustworthy quality.
- The standard single dose of 40 mg/kg may not be curative and higher-dose regimens should be given in split doses.
- Praziquantel does not act on ova or immature worms.
- Most schistosome-induced pathology resolves after praziquantel treatment.
- True drug resistance to praziquantel has not been convincingly demonstrated.
- Derivatives of artemisinin have shown effectiveness against immature stages of schistosomiasis.
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