Questions and Answers
What is the MOA of pramipexole/Mirapex?
Binds and activates dopamine receptors; mildly blocks serotonin and A-adrenergic receptors.
Pramipexole is also known as what?
Mirapex.
Mirapex is also known as what?
Pramipexole.
Pramipexole/Mirapex is what classification of drug?
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Monotherapy pramipexole/Mirapex is used for what?
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Pramipexole/Mirapex can be used as an adjunct to what?
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What is the maximum oral dose of pramipexole for treatment of Parkinson's?
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What is the maximum IR dose of pramipexole for treatment of Parkinson's?
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What is the maximum ER dose of pramipexole for treatment of Parkinson's?
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What are the adverse effects of pramipexole/Mirapex?
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What are the adverse effects of pramipexole when taken in combination with levodopa?
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Pramipexole interacts with what drugs?
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Pramipexole use is contraindicated when?
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When taking pramipexole/Mirapex, what patient education should be provided?
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Study Notes
Pramipexole Overview
- Pramipexole, also known as Mirapex, is a medication that activates dopamine receptors while mildly blocking serotonin and A-adrenergic receptors.
- Classified as a non-ergot dopamine receptor agonist, it primarily stimulates dopamine receptors to improve motor function.
Indications and Uses
- Monotherapy with pramipexole is indicated for the treatment of restless leg syndrome, aimed at improving motor performance.
- It can be used alongside levodopa to allow for lower dosing, thus helping to reduce motor control fluctuations.
Dosage Information
- Maximum oral and immediate-release dosages for treating Parkinson's disease are 1.5 mg taken three times daily (TID).
- For extended-release formulations, the maximum dosage is 4.5 mg taken four times daily (QID).
Adverse Effects
- Common adverse effects include nausea, constipation, dizziness, daytime somnolence, insomnia, sleep attacks, weakness, and hallucinations.
- When taken with levodopa, adverse effects may exacerbate, leading to increased risk of hallucination, daytime sleepiness, and postural hypotension.
Drug Interactions and Contraindications
- Pramipexole interacts with cimetidine, necessitating caution when used in combination.
- Use is contraindicated in patients with compulsive behavior and renal impairment, requiring a dosage reduction.
Patient Education
- Patients should be informed that it may take several weeks to observe the effects of pramipexole treatment, emphasizing the need for adherence to the prescribed regimen.
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Description
Test your knowledge on Pramipexole, its uses, dosages, and potential adverse effects. This quiz covers important information about this medication, including its role in treating conditions like restless leg syndrome and Parkinson's disease. Challenge yourself to see how well you understand this critical drug.
