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Questions and Answers
What is the generic name of Pramipexole?
What is the generic name of Pramipexole?
- Antiparkinson agent
- Dopamine-receptor agonist
- Mirapex
- Pramipexole (correct)
Which of the following are trade names for Pramipexole?
Which of the following are trade names for Pramipexole?
- Mirapex (correct)
- Dopamine-receptor agonist
- Pramipexole
- Mirapex ER (correct)
What is the functional class of Pramipexole?
What is the functional class of Pramipexole?
Antiparkinson agent
What is the chemical class of Pramipexole?
What is the chemical class of Pramipexole?
List some uses of Pramipexole.
List some uses of Pramipexole.
What is the mechanism of action (M.O.A) for Pramipexole?
What is the mechanism of action (M.O.A) for Pramipexole?
What contraindication is associated with Pramipexole?
What contraindication is associated with Pramipexole?
What is the standard adult dose for Parkinson's disease using Pramipexole?
What is the standard adult dose for Parkinson's disease using Pramipexole?
What is the adult dosage for Restless legs syndrome?
What is the adult dosage for Restless legs syndrome?
What is the renal dose adjustment for Pramipexole?
What is the renal dose adjustment for Pramipexole?
What are some side effects of Pramipexole?
What are some side effects of Pramipexole?
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Study Notes
Pramipexole Overview
- Generic name: Pramipexole
- Trade names include Mirapex and Mirapex ER
- Classified as an antiparkinson agent
Chemical Information
- Chemical class: Non-ergot dopamine-receptor agonist
- Mechanism of action: Selective agonist for D₂ receptors at both presynaptic and postsynaptic sites, with binding at D₃ receptor enhancing antiparkinson effects
Indications and Uses
- Primary uses include treatment for idiopathic Parkinson's disease and restless legs syndrome
Dosage Guidelines
- Parkinson's disease: Initial dose for adults is 0.125 mg taken three times daily, with gradual increases by 0.125 mg at 5-7 day intervals to achieve a maximum daily dose of 4.5 mg. Extended-release starts at 0.375 mg daily, can increase to 0.75 mg daily, max 4.5 mg/day.
- Restless legs syndrome: Initial dose is 0.125 mg taken 2-3 hours before bedtime, with gradual increases, maximum of 0.5 mg/day.
- Renal dosing: For adult patients with a creatinine clearance of 35-59 mL/min, start at 0.125 mg twice daily; for 15-34 mL/min, start at 0.125 mg daily. Increase as needed.
Side Effects
- CNS: Can cause agitation, insomnia, psychosis, hallucinations, depression, dizziness, headache, confusion, amnesia, dream disorders, fatigue, dyskinesia, excessive sleepiness, and sudden sleep onset.
- Cardiovascular: Orthostatic hypotension, edema, syncope, tachycardia, increased blood pressure, and heart failure can occur.
- EENT: Patients may experience blurred vision and retinal/vision deterioration.
- Endocrine: May affect antidiuretic hormone secretion (causing SIADH).
- Gastrointestinal: Possible side effects include nausea, anorexia, constipation, dysphagia, and dry mouth.
- Genitourinary: Impotence and increased urinary frequency reported.
- Hematological: Risk of hemolytic anemia, leukopenia, and agranulocytosis.
- Integumentary: Pruritus may occur.
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