Pramipexole Flashcards
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Questions and Answers

What is the generic name of Pramipexole?

  • Antiparkinson agent
  • Dopamine-receptor agonist
  • Mirapex
  • Pramipexole (correct)
  • Which of the following are trade names for Pramipexole?

  • Mirapex (correct)
  • Dopamine-receptor agonist
  • Pramipexole
  • Mirapex ER (correct)
  • What is the functional class of Pramipexole?

    Antiparkinson agent

    What is the chemical class of Pramipexole?

    <p>Dopamine-receptor agonist, non-ergot</p> Signup and view all the answers

    List some uses of Pramipexole.

    <p>Idiopathic Parkinson's disease, restless legs syndrome</p> Signup and view all the answers

    What is the mechanism of action (M.O.A) for Pramipexole?

    <p>Selective agonist for D₂ receptors (presynaptic/postsynaptic sites); binding at D₃ receptor contributes to antiparkinson effects.</p> Signup and view all the answers

    What contraindication is associated with Pramipexole?

    <p>Hypersensitivity</p> Signup and view all the answers

    What is the standard adult dose for Parkinson's disease using Pramipexole?

    <p>PO 0.125 mg tid; increase gradually by 0.125 mg/dose at 5- to 7-day intervals until a total daily dose of 4.5 mg/day is reached.</p> Signup and view all the answers

    What is the adult dosage for Restless legs syndrome?

    <p>PO 0.125 mg 2-3 hr before bedtime, increase gradually, max 0.5 mg/day.</p> Signup and view all the answers

    What is the renal dose adjustment for Pramipexole?

    <p>For CCr 35-59 mL/min, 0.125 mg bid, may increase q5-7days to 1.5 mg bid if required; for CCr 15-34 mL/min, 0.125 mg/day, increase q5-7days to 1.5 mg/day.</p> Signup and view all the answers

    What are some side effects of Pramipexole?

    <p>CNS: Agitation, insomnia, psychosis, hallucinations, depression, dizziness, headache, confusion, amnesia, dream disorder, asthenia, dyskinesia, hypersomnolence, sudden sleep onset, impulse control disorders. CV: Orthostatic hypotension, edema, syncope, tachycardia, increased B/P, heart rate, heart failure. EENT: Blurred vision, retinal/vision deterioration.</p> Signup and view all the answers

    Study Notes

    Pramipexole Overview

    • Generic name: Pramipexole
    • Trade names include Mirapex and Mirapex ER
    • Classified as an antiparkinson agent

    Chemical Information

    • Chemical class: Non-ergot dopamine-receptor agonist
    • Mechanism of action: Selective agonist for D₂ receptors at both presynaptic and postsynaptic sites, with binding at D₃ receptor enhancing antiparkinson effects

    Indications and Uses

    • Primary uses include treatment for idiopathic Parkinson's disease and restless legs syndrome

    Dosage Guidelines

    • Parkinson's disease: Initial dose for adults is 0.125 mg taken three times daily, with gradual increases by 0.125 mg at 5-7 day intervals to achieve a maximum daily dose of 4.5 mg. Extended-release starts at 0.375 mg daily, can increase to 0.75 mg daily, max 4.5 mg/day.
    • Restless legs syndrome: Initial dose is 0.125 mg taken 2-3 hours before bedtime, with gradual increases, maximum of 0.5 mg/day.
    • Renal dosing: For adult patients with a creatinine clearance of 35-59 mL/min, start at 0.125 mg twice daily; for 15-34 mL/min, start at 0.125 mg daily. Increase as needed.

    Side Effects

    • CNS: Can cause agitation, insomnia, psychosis, hallucinations, depression, dizziness, headache, confusion, amnesia, dream disorders, fatigue, dyskinesia, excessive sleepiness, and sudden sleep onset.
    • Cardiovascular: Orthostatic hypotension, edema, syncope, tachycardia, increased blood pressure, and heart failure can occur.
    • EENT: Patients may experience blurred vision and retinal/vision deterioration.
    • Endocrine: May affect antidiuretic hormone secretion (causing SIADH).
    • Gastrointestinal: Possible side effects include nausea, anorexia, constipation, dysphagia, and dry mouth.
    • Genitourinary: Impotence and increased urinary frequency reported.
    • Hematological: Risk of hemolytic anemia, leukopenia, and agranulocytosis.
    • Integumentary: Pruritus may occur.

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    Description

    Test your knowledge of Pramipexole with these flashcards. Learn about its generic and trade names, classification, and uses in treating conditions like Parkinson's disease. Perfect for students in pharmacology or those preparing for medical exams.

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