Questions and Answers
What is the therapeutic classification of Pramipexole (Marapex)?
What is the pharmacological classification of Pramipexole?
What are the therapeutic indications for Pramipexole?
Idiopathic PD, monotherapy in early PD, combination with levodopa in advanced stages, moderate to severe cases of restless leg syndrome.
What is the mechanism of action of Pramipexole?
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The metabolism of Pramipexole is __________.
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The excretion of Pramipexole is __________.
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Which of the following are adverse effects of Pramipexole? (Select all that apply)
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Which condition is a contraindication for the use of Pramipexole?
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What should be monitored when a patient is on Pramipexole?
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Which of the following can decrease the action of Pramipexole?
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Study Notes
Pramipexole (Marapex) Overview
- Classified as an antiparkinsonian drug.
- Falls under the category of non-ergot dopamine receptor agonists.
Therapeutic Indications and Uses
- Primarily used for idiopathic Parkinson's Disease (PD); effective as monotherapy in early stages and in combination with levodopa in advanced stages.
- Significantly improves motor function in early PD and reduces motor performance fluctuations in later stages.
- Allows for a reduction in levodopa dosage when used together.
- Treats moderate to severe restless leg syndrome.
- Reduces tremors and rigidity associated with Parkinson’s disease, as well as alleviates leg restlessness.
Mechanism of Action
- Stimulates dopamine receptors in both presynaptic and postsynaptic sites within the striatum of the brain.
- Restores the balance of dopaminergic activity by binding to dopamine receptors.
Pharmacokinetics
- Metabolized hepatic (liver).
- Excreted via renal (kidney) pathways.
Adverse Effects
- Potential for amnesia, dizziness, drowsiness, hallucinations, weakness, constipation, dry mouth, dyspepsia, nausea, and orthostatic hypotension.
- Notable risk of sleep attacks that can occur unpredictably.
Contraindications and Precautions
- Contraindicated in individuals with hypersensitivity and major psychotic disorders.
- Use with caution in patients with renal, hepatic, or cardiac diseases, those taking CNS depressants, and patients with a history of psychosis, dyskinesia, or affective disorders.
Drug Interactions
- Dopamine antagonists can decrease the effectiveness of pramipexole.
- Levels may increase when taken with levodopa, cimetidine, ranitidine, diltiazem, verapamil, or quinidine.
- Kava may reduce the drug's efficacy.
Nursing Considerations and Patient Teaching
- Recommend administration with meals to reduce the risk of nausea.
- Patients should be informed of possible drowsiness and the risk of sudden sleep episodes; advise against engaging in activities requiring full alertness until they understand how the medication affects them.
- Encourage gradual position changes to help mitigate orthostatic hypotension.
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Description
This quiz features flashcards focused on Pramipexole (Marapex), covering its therapeutic and pharmacological classifications, as well as its uses in treating Parkinson's disease. It's designed to help you reinforce your understanding of this important antiparkinson drug.
